Co‐Morbidity of Smoking in Patients with Psychiatric and Substance Use Disorders
Open accessAbstract
This article reviews cigarette smoking in patients with psychiatric disorders (PD) and substance use disorders (SUD). Rates of smoking are approximately 23% in the U.S. population but approximately twoto four‐fold higher in patients with PD and SUD. Many remaining smokers have had repeated smoking cessation failures, possibly due to the presence of co‐morbid PD and SUDs. There is modest, evidence‐based support for effective treatment interventions for nicotine addiction in PD and SUD. Further research is needed to increase our understanding of nicotine addiction in PD and SUD and develop more effective treatment interventions.
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A large proportion of smokers report smoking to control symptoms of anxiety and depression, and the rate of smoking in individuals with affective disorders is more than double the general population rate.
“Similarly, a large proportion of smokers report that they smoke to control symptoms of anxiety and depression (Picciotto et al. 2002), and the rate of smoking in individuals with affective disorders is more than double the rate in the general population (Kalman et al. 2005).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Kalman et al. 2005
Only the smoking-rate clause is attributed to Kalman et al.; the claim about smoking to control symptoms cites Picciotto et al. The Abstract reports a general-population rate of about 23% and smoking rates of 55–70% in bipolar disorder, supporting a more-than-double comparison for bipolar disorder. But it reports 40–60% for major depression, so more than double is not supported across the full reported range of affective disorders. (LLM, conf=0.85)
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- Authors
- Kalman, D., Morissette, S. B., & George, T. P.
- Affiliations
- Boston University (US)
- Yale University (US)
- Corresponding author
- George, Tony P.
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2005-03-04
- Volume
- 14
- Issue
- 2
- Pages
- 106-123
- ISSN
- 1055-0496 (ISSN-L)
- 1521-0391
- PMC
- PMC1199553
- OpenAlex
- W2109605442
- Cited by
- 594
- References
- 168
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 11 · 2023: 20 · 2022: 26 · 2021: 19 · 2020: 44 · 2019: 20 · 2018: 37 · 2017: 32 · 2016: 38 · 2015: 32 · 2014: 36 · 2013: 43 · 2012: 35
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01-DA-1-4039, R01 DA15757, R29-DA-11713, R01-DA-1-3672, R01DA013672, R01DA015757, R29DA011713, K23DA016376, K02-DA-16611, R01DA014039, K23-DA-16376, K02DA016611)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- cigarette smoking, mental illness, substance use disorders, comorbidities, nicotine dependence, smoking cessation, tobacco dependence treatment
- MeSH terms
- Mental Disorders, Forecasting, Humans, Smoking, Time Factors, United States, Comorbidity, Diagnosis, Dual (Psychiatry), Neurotransmitter Agents, Substance-Related Disorders
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