Nitrogen regulation in Saccharomyces cerevisiae
Abstract
Yeast cells can respond to growth on relatively poor nitrogen sources by increasing expression of the enzymes for the synthesis of glutamate and glutamine and by increasing the activities of permeases responsible for the uptake of amino acids for use as a source of nitrogen. These general responses to the quality of nitrogen source in the growth medium are collectively termed nitrogen regulation. In this review, we discuss the historical foundations of the study of nitrogen regulation as well as the current understanding of the regulatory networks that underlie nitrogen regulation. One focus of the review is the array of four GATA type transcription factors which are responsible for the regulation the expression of nitrogen-regulated genes. They are the activators Gln3p and Nil1p and their antagonists Nil2p and Dal80p. Our discussion includes consideration of the DNA elements which are the targets of the transcription factors and of the regulated translocation of Gln3p and Nil1p from the cytoplasm to the nucleus. A second focus of the review is the nitrogen regulation of the general amino acid permease, Gap1p, and the proline permease, Put4p, by ubiquitin mediated intracellular protein sorting in the secretory and endosomal pathways.
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In Saccharomyces cerevisiae, nitrogen consumption is controlled by Nitrogen Catabolism Repression (NCR), which senses nitrogen sources and concentration; under preferred nitrogen sources (ammonium), NCR represses absorption of other sources.
“In Saccharomyces cerevisiae is known that nitrogen consumption is controlled by Nitrogen Catabolism Repression (NCR), which yeast can sense the nitrogen sources and its concentration in the medium; under the presence of preferred nitrogen sources (ammonium), NCR represses the absorption of other fonts (Magasanik and Kaiser 2002).”
From Phosphate solubilization and indole acetic acid production by rhizosphere yeast Torulaspora globosa: improvement of culture conditions for better performance in vitro (2022) · cites this paper as Magasanik and Kaiser 2002
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- Authors
- Magasanik, B., & Kaiser, C. A.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Magasanik, Boris
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 290
- Issue
- 1-2
- Pages
- 1-18
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2045776897
- Cited by
- 669
- References
- 1
- Citations by year
- 2026: 24 · 2025: 18 · 2024: 38 · 2023: 23 · 2022: 18 · 2021: 26 · 2020: 25 · 2019: 39 · 2018: 33 · 2017: 36 · 2016: 30 · 2015: 22 · 2014: 37 · 2013: 28 · 2012: 32
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Keywords
- nitrogen regulation, Saccharomyces cerevisiae, GATA transcription factors, nuclear translocation, general amino acid permease, secretory pathway, endocytic pathway, amino acid permease
- MeSH terms
- Amino Acids, Biological Transport, Cell Division, Ketoglutaric Acids, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Nitrogen Compounds, Amino Acid Transport Systems
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