Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries
Abstract
The aqueous extract of the Panax ginseng (GE) potentiated the relaxation induced by transmural electrical stimulation or nicotine in monkey cerebral arterial strips denuded of the endothelium and partially contracted with prostaglandin F(2 alpha). The response to electrical stimulation was abolished by tetrodotoxin, whereas that to nicotine was suppressed by hexamethonium. N(G)-nitro-L-arginine abolished both of the neurogenic relaxation. Atropine did not alter the potentiating effect of GE. Relaxations induced by exogenous NO were unaffected by GE. The enhancement by GE, of the neurogenic response, appears to be associated with increment in the synthesis or release of NO from the perivascular nerve. Blockade of muscarinic prejunctional inhibition, superoxide scavenging action and phosphodiesterase inhibition are not involved.
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Ginseng prevents stimulation of voltage-dependent brain sodium ion channels.
“prevent the stimulation of voltage-dependent brain sodium ion channels [102]”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [102]
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Phytotherapy: A promising approach for the treatment of Alzheimer's disease
John, O. O., Amarachi, I. S., Chinazom, A. P., Adaeze, E., Kale, M. B., Umare, M. D., & Upaganlawar, A. B. (2022) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100030 · Cited by 69 · see citing works
- Authors
- Toda, N., Ayajiki, K., Fujioka, H., & Okamura, T.
- Affiliations
- Shiga University of Medical Science (JP)
- Corresponding author
- Okamura, Tomio
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 76
- Issue
- 1
- Pages
- 109-113
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2039077239
- Cited by
- 34
- References
- 18
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2016: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Smoking Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Keywords
- ginsenosides, Panax ginseng, nitric oxide, neurogenic vasodilatation, cerebral arteries, perivascular nerves, electrical stimulation, tetrodotoxin, hexamethonium, L-NNA, superoxide, phosphodiesterase inhibition
- MeSH terms
- Animals, Central Nervous System Agents, Cerebral Arteries, Chromatography, High Pressure Liquid, Drug Synergism, Electric Stimulation, Female, Macaca, Male, Nitric Oxide, Plant Extracts, Saponins, Vasodilation, Ginsenosides
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