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Cited by 335Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAging and Gerontology Research

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The network and the remodeling theories of aging: historical background and new perspectives

Franceschi, C, Valensin, S, Bonafè, M, Paolisso, G, Yashin, A.I, Monti, D, De Benedictis, G·2000·Experimental Gerontology
DOI 10.1016/s0531-5565(00)00172-8
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Abstract

Two general theories, i.e. "the network theory of aging" (1989) and "the remodeling theory of aging" (1995), as well as their implications, new developments, and perspectives are reviewed and discussed. Particular attention has been paid to illustrate: (i) how the network theory of aging fits with recent data on aging and longevity in unicellular organisms (yeast), multicellular organisms (worms), and mammals (mice and humans); (ii) the evolutionary and experimental basis of the remodeling theory of aging (immunological, genetic, and metabolic data in healthy centenarians, and studies on the evolution of the immune response, stress and inflammation) and its recent development (the concepts of "immunological space" and "inflamm-aging"); (iii) the profound relationship between these two theories and the data which suggest that aging and longevity are related, in a complex way, to the capability to cope with a variety of stressors.

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Metadata

Authors
Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D., & De Benedictis, G.
Affiliations
  • Istituto Nazionale di Riposo e Cura per Anziani (IT)
  • University of Bologna (IT)
  • University of Campania "Luigi Vanvitelli" (IT)
  • Max Planck Institute for Demographic Research (DE)
  • University of Florence (IT)
Corresponding author
Franceschi, C
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2000-09
Volume
35
Issue
6-7
Pages
879-896
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/s0531-5565(00)00172-8
OpenAlex
W1984265860
Cited by
335
References
0
Citations by year
2026: 3 · 2025: 5 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 17 · 2020: 14 · 2019: 15 · 2018: 17 · 2017: 23 · 2016: 16 · 2015: 16 · 2014: 15 · 2013: 16 · 2012: 16
FWCI
3.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords
aging, longevity, centenarians, inflammaging, stress response, inflammation, stress tolerance, unicellular organisms, yeast, Caenorhabditis elegans, mice, human
MeSH terms
Aging, Animals, Biological Evolution, Heat-Shock Proteins, Humans, Immune System, Inflammation, Saccharomyces cerevisiae, Mice

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