Cited by 335Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAging and Gerontology Research

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The network and the remodeling theories of aging: historical background and new perspectives

Franceschi, C, Valensin, S, Bonafè, M, Paolisso, G, Yashin, A.I, Monti, D, De Benedictis, G·2000·Experimental Gerontology

DOI 10.1016/s0531-5565(00)00172-8

Open this paper in CoChat — free account

Abstract

Two general theories, i.e. "the network theory of aging" (1989) and "the remodeling theory of aging" (1995), as well as their implications, new developments, and perspectives are reviewed and discussed. Particular attention has been paid to illustrate: (i) how the network theory of aging fits with recent data on aging and longevity in unicellular organisms (yeast), multicellular organisms (worms), and mammals (mice and humans); (ii) the evolutionary and experimental basis of the remodeling theory of aging (immunological, genetic, and metabolic data in healthy centenarians, and studies on the evolution of the immune response, stress and inflammation) and its recent development (the concepts of "immunological space" and "inflamm-aging"); (iii) the profound relationship between these two theories and the data which suggest that aging and longevity are related, in a complex way, to the capability to cope with a variety of stressors.

Integrity signals

Registry

Crossref · 10.1016/s0531-5565(00)00172-8

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712
Admission criteria for immunogerontological studies in man: The senieur protocol
Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90152-0 · Cited by 754
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665
Self-citation
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
Franceschi, C., Bonafè, M., & Valensin, S. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00513-7 · Cited by 495
Self-citation
Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians
FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-689.x · Cited by 362
Self-citation
Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load
Franceschi, C., Valensin, S., Fagnoni, F., Barbi, C., & Bonafè, M. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00068-6 · Cited by 154
Self-citation
Neurosecretory control of aging in Caenorhabditis elegans
Ailion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., & Thomas, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7394 · Cited by 121

Show all 0 references

Research works printed but not linked: 62

Aspinall, 1999, Does the immune system of a mouse age faster than the immune system of a human?, Bioessays, 21, 519, 10.1002/(SICI)1521-1878(199906)21:6<519::AID-BIES8>3.0.CO;2-U · DOI
Babar, 1999, P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans, Neurobiol. Aging, 20, 513, 10.1016/S0197-4580(99)00094-9 · DOI
Baggio, 1998, Lipoprotein(a) and lipoprotein profiles in healthy centenarians: a reappraisal of vascular risk factors, FASEB J., 12, 433, 10.1096/fasebj.12.6.433 · DOI
Bagnara, 2000, Hemopoiesis in healthy old people and centenarians: well maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network, J. Gerontol. A: Biol. Sci. Med. Sci., 55, B61, 10.1093/gerona/55.2.B61 · DOI
Bellavia, 1999, C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians, J. Gerontol. A: Biol. Sci. Med. Sci., 54, B150, 10.1093/gerona/54.4.B150 · DOI
Blake, 1995, Blood pressure and heat shock protein expression in response to acute and chronic stress, Hypertension, 25, 539, 10.1161/01.HYP.25.4.539 · DOI
Blake, 1991, Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response, Proc. Natl. Acad. Sci. USA, 88, 9873, 10.1073/pnas.88.21.9873 · DOI
Castellani, 1999, Impaired renal adaptation to stress in the elderly with isolated systolic hypertension, Hypertension, 34, 1106, 10.1161/01.HYP.34.5.1106 · DOI
Castellani, 1998, Excessive vasoconstriction after stress by the aging kidney: inadequate prostaglandin modulation of increased endothelin activity, J. Lab. Clin. Med., 132, 186, 10.1016/S0022-2143(98)90167-6 · DOI
Cossarizza, 1996, CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to healthy centenarians: implications for T cell memory, Mech. Ageing Dev., 86, 173, 10.1016/0047-6374(95)01691-0 · DOI
De Benedictis, 1998, Age-related changes of the 3’APOB VNTR genotype pool in ageing cohorts, Ann. Hum. Genet., 62, 115, 10.1017/S0003480098006757 · DOI
De Benedictis, 1998, Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2), Eur. J. Hum. Genet., 6, 534, 10.1038/sj.ejhg.5200222 · DOI
De Benedictis, G., Rose, G., Carrieri, G., De Luca, M., Falcone, E., Passarino, G., Bonafe, M., Monti, D., Baggio, G., Bertolini, S., Mari, D., Mattace, R., Franceschi, C., 1999. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J. 13, 1532–1536. · DOI
Doria, 1997, Genes, immunity, and senescence: looking for a link, Immunol. Rev., 160, 159, 10.1111/j.1600-065X.1997.tb01036.x · DOI
Ernst, 1999, The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery, Immunity, 11, 173, 10.1016/S1074-7613(00)80092-8 · DOI
Fagnoni, 2000, Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging, Blood, 95, 2860, 10.1182/blood.V95.9.2860.009k35_2860_2868 · DOI
Franceschi, 1989, Cell proliferation and cell death in the aging process, Aging Clin. Exp. Res., 1, 3, 10.1007/BF03323871 · DOI
Franceschi, 1995, The immunology of exceptional individuals: the lesson of centenarians, Immunol. Today, 16, 12, 10.1016/0167-5699(95)80064-6 · DOI
Franceschi, 1995, The reshaping of the immune system with age, Int. Rev. Immunol., 12, 1, 10.3109/08830189509056697 · DOI
Franceschi, 2000, Do men and women follow different trajectories to reach extreme longevity?, Aging Clin. Exp. Res., 12, 77, 10.1007/BF03339894 · DOI
Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N.Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x · DOI · Paper page
George, 1996, Thymic involution with ageing: obsolescence or good housekeeping?, Immunol. Today, 17, 267, 10.1016/0167-5699(96)80543-3 · DOI
Hamet, 1994, Genes of stress in experimental hypertension, Clin. Exp. Pharmacol. Physiol., 11, 907, 10.1111/j.1440-1681.1994.tb02464.x · DOI
Jaattela, 1999, Escaping cell death: survival proteins in cancer, Exp. Cell. Res., 248, 30, 10.1006/excr.1999.4455 · DOI
Jazwinski, 1999, The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity, Neurobiol. Aging, 20, 471, 10.1016/S0197-4580(99)00095-0 · DOI
Kawano, 2000, Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans, Biochem. Biophys. Res. Commun., 273, 431, 10.1006/bbrc.2000.2971 · DOI
Kieper, 1999, Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands, Proc. Natl. Acad. Sci. USA, 96, 13 306, 10.1073/pnas.96.23.13306 · DOI
Kirkwood, 1992, Is ageing as complex as it would appear? New perspectives in gerontological research, Ann. N.Y. Acad. Sci., 663, 412, 10.1111/j.1749-6632.1992.tb38685.x · DOI
Kirkwood, 1979, The evolution of ageing and longevity, Proc. R. Soc. Lond. B: Biol. Sci., 205, 531, 10.1098/rspb.1979.0083 · DOI
Kirkwood, 1977, Evolution of ageing, Nature, 270, 301, 10.1038/270301a0 · DOI
Kowald, A., Kirkwood, T.B, 1994. Towards a network theory of ageing: a model combining the free radical theory and the protein error theory. J. Theor. Biol. 168, 75–94. · DOI
Kowald, A., Kirkwood, T.B, 1996. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat. Res. 316, 209–236. · DOI
Ku, 1997, CD8+ T-cell clones in old mice, Immunol. Rev., 160, 139, 10.1111/j.1600-065X.1997.tb01034.x · DOI
Lee, 1999, Gene expression profile of aging and its retardation by caloric restriction, Science, 285, 1390, 10.1126/science.285.5432.1390 · DOI · Paper page
Lung, 2000, Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells, Vaccine, 18, 1606, 10.1016/S0264-410X(99)00494-6 · DOI
Mariotti, 1992, Thyroid and other organ-specific autoantibodies in healthy centenarians, Lancet, 339, 1506, 10.1016/0140-6736(92)91265-A · DOI
Murali-Krishna, 1999, Persistence of memory CD8 T cells in MHC class I-deficient mice, Science, 286, 1377, 10.1126/science.286.5443.1377 · DOI
Ottaviani, 1996, The neuroimmunology of stress from invertebrates to man, Progr. Neurobiol., 48, 421, 10.1016/0301-0082(95)00049-6 · DOI
Ottaviani, 1997, The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine system, Immunol. Today, 18, 169, 10.1016/S0167-5699(97)84663-4 · DOI
Ottaviani, 1997, Pro-opiomelanocortin-derived peptides, cytokines, and nitric oxide in immune responses and stress: an evolutionary perspective, Int. Rev. Cytol., 170, 79, 10.1016/S0074-7696(08)61621-6 · DOI
Ottaviani, 1998, The neuro-immunological interface in an evolutionary perspective: the dynamic relationship between effector and recognition systems, Front. Biosci., 16, D431, 10.2741/A289 · DOI
Paganelli, 1992, Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population, Clin. Exp. Immunol., 90, 351, 10.1111/j.1365-2249.1992.tb07954.x · DOI
Paolisso, 1999, Advancing age and insulin resistance: new facts about an ancient history, Eur. J. Clin. Invest., 29, 758, 10.1046/j.1365-2362.1999.00522.x · DOI
Paolisso, 1997, Preserved antilipolytic insulin action is associated with a less atherogenic plasma lipid profile in healthy centenarians, J. Am. Geriatr. Soc., 45, 1504, 10.1111/j.1532-5415.1997.tb03203.x · DOI
Paolisso, 1997, Serum levels of insulin like growth factor-1 (IGF-1) and IGF-binding protein 3 in healthy centenarians: relationship with plasma leptin and lipid concentration, insulin action and cognitive function, J. Clin. Endocrinol. Metab., 82, 2204, 10.1210/jc.82.7.2204 · DOI
Paolisso, 1995, Body composition, body fat distribution and resting metabolic rate in healthy centenarians, Am. J. Clin. Nutr., 50, 746, 10.1093/ajcn/62.4.746 · DOI
Paolisso, 1998, Oxidative stress and advancing age: results in healthy centenarians, J. Am. Geriat. Soc., 46, 833, 10.1111/j.1532-5415.1998.tb02716.x · DOI
Paolisso, 2000, Metabolic age remodeling: the lesson from centenarians, Eur. J. Clin. Inv., 10.1046/j.1365-2362.2000.00729.x · DOI
Sansoni, 1993, Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians, Blood, 80, 2767, 10.1182/blood.V82.9.2767.2767 · DOI
Sansoni, 1997, T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians, Mech. Aging Dev., 96, 127, 10.1016/S0047-6374(97)01887-3 · DOI
Schwab, 1997, Expanded CD4+ and CD8+ T cell clones in elderly humans, J. Immunol., 158, 4493, 10.4049/jimmunol.158.9.4493 · DOI
Shama, 1998, Heat stress-induced life span extension in yeast, Exp. Cell. Res., 245, 379, 10.1006/excr.1998.4279 · DOI · Paper page
Shama, 1998, Role of RAS2 in recovery from chronic stress: effect on yeast life span, Exp. Cell. Res., 245, 368, 10.1006/excr.1998.4276 · DOI
Swain, 1999, Class II-independent generation of CD4 memory T cells from effectors, Science, 286, 1381, 10.1126/science.286.5443.1381 · DOI
Tanchot, 1998, The organization of mature T-cell pools, Immunol. Today, 19, 575, 10.1016/S0167-5699(98)01344-9 · DOI
Udelsman, 1994, Endocrine control of stress-induced heat shock protein 70 expression in vivo, Surgery, 115, 611
Udelsman, 1993, Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response, J. Clin. Invest., 91, 465, 10.1172/JCI116224 · DOI
Valensin, 2000, A theoretical model for “in machimna” experiments on immunosenescence, Ann. N.Y. Acad. Sci., 908, 344, 10.1111/j.1749-6632.2000.tb06670.x · DOI
Wack, 1998, Age-related modifications of the human alfa beta T cell repertoire as a consequence of clonal expansions, Int. Immunol., 10, 1281, 10.1093/intimm/10.9.1281 · DOI
Yang, 1999, Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke, Am. J. Physiol., 276, H1961
Yashin, 1999, Genes, demography and life span: the contribution of demographic data in genetic studies of aging and longevity, Am. J. Hum. Genet., 65, 1178, 10.1086/302572 · DOI
Zinkernagel, 1997, Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity, Immunol. Rev., 156, 199, 10.1111/j.1600-065X.1997.tb00969.x · DOI

Sorted by citations

Items 101–200 of 287

Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study
Berendsen, A. A. M., Santoro, A., Pini, E., Cevenini, E., Ostan, R., Pietruszka, B., Rolf, K., Cano, N., Caillé, A., Lyon-Belgy, N., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.03.001 · Cited by 48
“Inflammageing plays a role in the onset of agerelated chronic diseases, e.g. atherosclerosis and type 2 diabetes mellitus, and geriatric conditions, e.g. sarcopenia, frailty and disability (Cevenini et al., 2013; Franceschi et al., 2000a, 2007).”
BackgroundSelf-citation
Trajectories of changes over twelve years in the health status of Canadians from late middle age
Mitnitski, A., Song, X., & Rockwood, K. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.06.015 · Cited by 68
Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
Rescigno, T., Micolucci, L., Tecce, M. F., & Capasso, A. (2017) · Molecules · doi:10.3390/molecules22010105 · Cited by 75
“Strong evidence indicates that most of the phenotypic characteristics of the aging process are induced by inflammaging, which is partly under genetic control and which results from continuous antigenic stimulation that continues after reproductive age, a phenomenon for which evolution has not provided [67,81,82].”
Background
The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
Moreau, J.-F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J.-L., Garagnani, P., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.005 · Cited by 67
Self-citation
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians
Bonafè, M., Barbi, C., Storci, G., Salvioli, S., Capri, M., Olivieri, F., Valensin, S., Monti, D., Gonos, E. S., Benedictis, G. D., et al. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00137-7 · Cited by 74
Self-citation
Chronic antigenic load and apoptosis in immunosenescence
Ginaldi, L., Martinis, M. D., Monti, D., & Franceschi, C. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.11.005 · Cited by 65
Self-citation
Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue
Reiter, R. J., Sharma, R., Romero, A., Manucha, W. A., Tan, D. X., Zuccari, D. A. P. D. C., & Chuffa, L. G. D. A. (2023) · Antioxidants · doi:10.3390/antiox12030695 · Cited by 63
Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice.
Puerto, M., Guayerbas, N., Álvarez, P., & la Fuente, M. D. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.03.021 · Cited by 63
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective
Franceschi, C., Ostan, R., Mariotti, S., Monti, D., & Vitale, G. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00170 · Cited by 74
Self-citation
Understanding and Modulating Ageing
Rattan, S. I. S., & Clark, B. F. C. (2005) · IUBMB Life · doi:10.1080/15216540500092195 · Cited by 62
“Several theoretical and mathematical models are being developed in order to understand the interactive nature of the biological networks and trade-oﬀs ( 55, 58 ).”
Background
The Role of the Kynurenine Pathway in the Pathophysiology of Frailty, Sarcopenia, and Osteoporosis
Ballesteros, J., Rivas, D., & Duque, G. (2023) · Nutrients · doi:10.3390/nu15143132 · Cited by 63
“This age-related chronic low-grade inflammation, called inflammaging, can induce significant changes in human tissues [26].”
Background
Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease
Moro‐García, M. A., Echeverría, A., Galán-Artímez, M. C., Suárez-García, F. M., Solano-Jaurrieta, J. J., y, P. A., Molina, B. D., Lambert, J. L., López‐Larrea, C., Morı́s, C., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.04.128 · Cited by 60
“Moreover, as a result of continual antigenic stress throughout life, both processes increase, and this is considered to be a major contributor to age-associated frailty, morbidity and mortality [5].”
Background
Sirtuin regulation in calorie restriction
Qiu, X., Brown, K. V., Moran, Y., & Chen, D. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.09.015 · Cited by 50
Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats
Durbin, S. M., Jackson, J. R., Ryan, M., Gigliotti, J., Alway, S., & Tou, J. C. (2013) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-013-0469-2 · Cited by 57
“Aging has been described as a progressive pro-inflammatory state [41].”
Toward precision interventions and metrics of inflammaging
Franceschi, C., Olivieri, F., Moskalev, A., Ivanchenko, M., & Santoro, A. (2025) · Nature Aging · doi:10.1038/s43587-025-00938-7 · Cited by 62
“…conceptualization of this complex scenario (the intriguing relationship between inflammaging and the aging of the immune system) would suggest that they are likely to start as two distinct phenomena that eventually interact with, deeply influence and drive each other, positively or negatively 5,6 .”
Self-citation
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells
Bian, F., Xiao, Y., Barbosa, F. L., de Souza, R. G., Hernandez, H., Yu, Z., Pflugfelder, S. C., & de Paiva, C. S. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0127-z · Cited by 58
Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes
Spazzafumo, L., Olivieri, F., Abbatecola, A. M., Castellani, G., Monti, D., Lisa, R., Galeazzi, R., Sirolla, C., Testa, R., Ostan, R., et al. (2011) · AGE · doi:10.1007/s11357-011-9348-8 · Cited by 56
Self-citation
Decline of tactile acuity in aging: a study of body site, blood flow, and lifetime habits of smoking and physical activity
Stevens, J. C., Alvarez-Reeves, M., DiPietro, L., Mack, G., & Green, B. (2003) · Somatosensory & motor research · doi:10.1080/08990220310001622997 · Cited by 55
“…who might fairly be described as examples of ‘‘successful aging’’ (Rowe and Kahn, 1982; Franceschi et al., 1995; Barbieri et al., 2001); that is, people whose genetic makeup lessens the effect of environmental stressors, such as tobacco smoke, throughout life (Franceschi et al., 2000).”
Background
Aging and Chronic Liver Disease
Maeso‐Díaz, R., & Gracia‐Sancho, J. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1715446 · Cited by 71
Preserved Immune Functions and Controlled Leukocyte Oxidative Stress in Naturally Long-lived Mice: Possible Role of Nuclear Factor Kappa B
Arranz, L., Caamaño, J., Lord, J. M., & de la Fuente, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq101 · Cited by 60
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging
Wilhelm, I., Nyúl-Tóth, Á., Kozma, M., Farkas, A. E., & Krizbai, I. A. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00106.2017 · Cited by 56
“Aging is the greatest risk factor for developing chronic diseases, many of which are directly linked to a persistent low-grade inflammation, called inflamm-aging (49).”
Background
Dynamic and thermodynamic models of adaptation
Gorban, A. N., Tyukina, T., Pokidysheva, L. I., & Smirnova, E. V. (2021) · Physics of Life Reviews · doi:10.1016/j.plrev.2021.03.001 · Cited by 64
“neither too weak nor too strong, in relation to the environment [51].”
Background
Cumulative Index of Elderly Disorders And Its Dynamic Contribution to Mortality And Longevity
Yashin, A. I., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Akushevich, L., & Ukraintseva, S. V. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0500 · Cited by 48
Self-citation
Lamin in inflammation and aging
Tran, J. R., Chen, H., Zheng, X., & Zheng, Y. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.03.004 · Cited by 66
Age-Related Changes of Claudin Expression in Mouse Liver, Kidney, and Pancreas
D’Souza, T., Sherman‐Baust, C. A., Poosala, S., Mullin, J. M., & Morin, P. J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp118 · Cited by 48
Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment
Olson, L., & Humpel, C. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.011 · Cited by 57
Variation Rhythms of Lymphocyte Subsets during Healthy Aging
Faria, A. M. C., de Moraes, S. M., de Freitas, L. H. F., Speziali, E., Soares, T. F., Neves, S. P. F., Vitelli-Avelar, D. M., Martins, M. Â., Barbosa, K. V. B. D., Soares, E. B., et al. (2008) · NeuroImmunoModulation · doi:10.1159/000156478 · Cited by 59
Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells From Differently Aged Participants
Neri, S., Gardini, A., Facchini, A., Olivieri, F., Franceschi, C., Ravaglia, G., & Mariani, E. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.3.285 · Cited by 47
“It has been demonstrated that a major characteristic of immunosenescence is the decline of virgin T cells as well as the accumulation of clones, mostly of memory and effector T cells, caused by chronic exposure to a variety of antigens (46,47) (mainly Epstein–Barr and cytomegalovirus antigens) (48,49).”
BackgroundSelf-citation
The allele (A) -110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women
Altomare, K., Greco, V., Bellizzi, D., Berardelli, M., Dato, S., Rango, F. D., Garasto, S., Rose, G., Feraco, E., Mari, V., et al. (2003) · Biogerontology · doi:10.1023/a:1025182615693 · Cited by 50
Self-citation
Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis
Omran, H. M., & Almaliki, M. S. (2020) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2020.06.004 · Cited by 45
Aging, cytomegalovirus (CMV) and influenza vaccine responses
Frasca, D., & Blomberg, B. B. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1105413 · Cited by 46
Mosaic aging
Walker, L. C., & Herndon, J. G. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.12.031 · Cited by 45
Sex and Age Specificity of Susceptibility Genes Modulating Survival at Old Age
Passarino, G., Montesanto, A., Dato, S., Giordano, S., Domma, F., Mari, V., Feraco, E., & Benedictis, G. D. (2006) · Human Heredity · doi:10.1159/000097305 · Cited by 52
Interleukin-6 −174G/C polymorphism and longevity: a follow-up study
Hurme, M., Lehtimäki, T. J., Jylhä, M. K., Karhunen, P. J., & Hervonen, A. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.10.001 · Cited by 50
Centenarians and supercentenarians: a black swan. Emerging social, medical and surgical problems
Vacante, M., D’Agata, V., Motta, M., Malaguarnera, G., Biondi, A., Basile, F., Malaguarnera, M., Gagliano, C., Drago, F., & Salamone, S. (2012) · BMC Surgery · doi:10.1186/1471-2482-12-s1-s36 · Cited by 74
“Some of centenarians had been affected by cancer in their life, but they survived, even though during an historical period when cancer treatment was not as developed as in the present days [90,91].”
Background
Biologia do envelhecimento: teorias, mecanismos e perspectivas
Teixeira, I. N. D. O., & Guariento, M. E. (2010) · Ciência & Saúde Coletiva · doi:10.1590/s1413-81232010000600022 · Cited by 83
Single nucleotide polymorphisms: aging and diseases
Bessenyei, B., M�rka, M., Urb�n, L., Zeher, M., & Semsei, I. (2004) · Biogerontology · doi:10.1007/s10522-004-2567-y · Cited by 39
“It was previously suspected (Cutler and Semsei 1989) that cancer and aging might have common roots but according to the hypothesis of Bonafe et al. (2002b; Franceschi et al. 2000b ) the alteration of the immune system with increasing age could contribute to the elevated frequency of age-related malignant diseases as w…”
Background
Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess
Arosio, B., Ostan, R., Mari, D., Damanti, S., Ronchetti, F., Arcudi, S., Scurti, M., Franceschi, C., & Monti, D. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.02.010 · Cited by 54
Self-citation
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation
Cianciulli, A., Calvello, R., Ruggiero, M., & Panaro, M. A. (2022) · Molecules · doi:10.3390/molecules27020341 · Cited by 60
Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality
Ostan, R., Monti, D., Mari, D., Arosio, B., Gentilini, D., Ferri, E., Passarino, G., Rango, F. D., D’Aquila, P., Mariotti, S., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly194 · Cited by 42
Self-citation
Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome
Sun, C., Fan, S., Wang, X., Lu, J., Zhang, Z., Wu, D., Shan, Q., & Zheng, Y. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.04.012 · Cited by 43
“It is well established that oxidative stress and inflammation promote the cellular aging process, and this chronic proinflammatory state is termed inflammaging [23].”
Background
Network strategies to understand the aging process and help age-related drug design
Simkó, G. I., Gyurkó, D. M., Veres, D. V., Nánási, T., & Csermely, P. (2009) · Genome Medicine · doi:10.1186/gm90 · Cited by 45
Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data
Yashin, A. I., Arbeev, K. G., Akushevich, I. V., Ukraintseva, S. V., Kulminski, A. M., Arbeeva, L. S., & Culminskaya, I. V. (2009) · Biogerontology · doi:10.1007/s10522-009-9243-1 · Cited by 40
“The authors emphasized an important role of progressive remodeling taking place in an aging organism which may partly compensate local aging related disturbances in functioning and thereby contribute to survival during the life course accompanying the aging process (Franceschi et al. 2000).”
Self-citation
Ecoimmunology: is there any room for the neuroendocrine system?
Ottaviani, E., Malagoli, D., Capri, M., & Franceschi, C. (2008) · BioEssays · doi:10.1002/bies.20801 · Cited by 41
Self-citation
Mast cells and the liver aging process
Grizzi, F., Caro, G. D., Laghi, L., Hermonat, P. L., Mazzola, P., Nguyen, D. D. T., Radhi, S., Figueroa, J. A., Cobos, E., Annoni, G., et al. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-9 · Cited by 41
“It is now accepted that aging is characterized by a peculiar state of chronic inflammation (the so-called “inflamm-aging”) under genetic control, which seems to be a consequence of a person’s life-long antigenic load [26-30] and leads to a long-term tissue-related risk of allcause mortality in older people [31,32].”
Background
Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics
Toussaint, O., Remacle, J., Dierick, J., Pascal, T., Frippiat, C. C., Royer, V., & Debacq‐Chainiaux, F. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00031-3 · Cited by 42
A Comprehensive Analysis of Cytokine Network in Centenarians
Pinti, M., Gibellini, L., Tartaro, D. L., Biasi, S. D., Nasi, M., Borella, R., Fidanza, L., Neroni, A., Troiano, L., Franceschi, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032719 · Cited by 48
“Inflammaging is characterized by the presence of elevated levels of proinflammatory cytokines such as Interleukin (IL)-6, IL-1β, Tumour Necrosis Factor (TNF)-α, IL-8, IL-15, acute phase proteins, and can be identified in the elderly regardless of the degree of frailty [3,4].”
BackgroundSelf-citation
Inflammaging in Endemic Areas for Infectious Diseases
Batista, M. A., Calvo-Fortes, F., Silveira‐Nunes, G., Camatta, G. C., Speziali, E., Turroni, S., Teixeira‐Carvalho, A., Martins‐Filho, O. A., Neretti, N., Maioli, T. U., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579972 · Cited by 43
“C-reactive protein) and can be identified in the elderly and super-elderly (centenarians) regardless of the degree of frailty (1, 5, 53).”
BackgroundSelf-citation
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age
Ramos-Chávez, L. A., Roldán-Roldán, G., García-Juárez, B., González‐Esquivel, D. F., de la Cruz, G. P., Pineda, B., Ortega, D. R., Muñoz, I. G., Herrera, B. J., Rı́os, C., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8604718 · Cited by 45
Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability
Frasca, D., Romero, M., Landin, A. M., Diaz, A., Riley, R. L., & Blomberg, B. B. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.002 · Cited by 35
“Aging is characterized by a disregulation between inflammatory and anti-inflammatory networks, which results in a low grade chronic pro-inflammatory status called inflammaging (Franceschi et al., 2000).”
Background
Remodeling of the immunoinflammatory network system in elderly cancer patients: Implications of inflamm-aging and tumor-specific hyperinflammation
Miki, C., Kusunoki, M., Inoue, Y., Uchida, K., Mohri, Y., Buckels, J. A. C., & McMaster, P. (2008) · Surgery Today · doi:10.1007/s00595-008-3766-y · Cited by 33
The influence of inflammation and frailty in the aging continuum
Arosio, B., Ferri, E., Mari, D., Tobaldini, E., Vitale, G., & Montano, N. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111872 · Cited by 42
Ageing as a price of cooperation and complexityPreprint
Kiss, H., Mihalik, Á., Nánási, T., Őry, B., Spiró, Z., Sőti, C., & Csermely, P. (2008) · Nature Precedings · doi:10.1002/bies.200800224 · Cited by 36
Lipoproteins, Vascular-Related Genetic Factors, and Human Longevity
Panza, F., D’Introno, A., Capurso, C. A., Colacicco, A. M., Seripa, D., Pilotto, A., Santamato, A., Capurso, A., & Solfrizzi, V. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0537 · Cited by 27
Exosomal vesicles enhance immunosuppression in chronic inflammation: Impact in cellular senescence and the aging process
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109771 · Cited by 36
Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines
Ostan, R., Bucci, L., Cevenini, E., Palmas, M. G., Pini, E., Scurti, M., Vescovini, R., Caruso, C., Mari, D., Vitale, G., et al. (2012) · AGE · doi:10.1007/s11357-012-9483-x · Cited by 33
Self-citation
An allele of HRAS1 3′variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity
Bonafè, M., Barbi, C., Olivieri, F., Yashin, A. I., Andreev, K. F., Vaupel, J. W., Benedictis, G. D., Rose, G., Carrieri, G., Jazwinski, S. M., et al. (2002) · Gene · doi:10.1016/s0378-1119(01)00812-5 · Cited by 36
“The male/female ratio in centenarians was representative of that found in a nation-wide demographic survey on Italian centenarians (Franceschi et al., 2000).”
BackgroundResultSelf-citation
Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction via Overexpression of SIGIRR to Inhibit NF-κB Signaling Pathway
Xu, X.-M., Ning, Y., Wang, W., Liu, J., Bai, X., Sun, X., Cai, G., & Chen, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430248 · Cited by 34
Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes
Coelho, V. D. M., Bunbury, A., Rangel, L. B. A., Giri, B., Weeraratna, A. T., Morin, P. J., Bernier, M., & Taub, D. D. (2010) · International Journal of Medical Sciences · doi:10.7150/ijms.7.1 · Cited by 34
“This increase also appears to correlate with observed increases in circulating levels of proinflammatory cytokines during aging (7).”
The Contextualized Genetics of Human Longevity
Franceschi, C., Garagnani, P., Olivieri, F., Salvioli, S., & Giuliani, C. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.032 · Cited by 37
Self-citation
Mechanisms of Brain Aging Regulation by Insulin: Implications for Neurodegeneration in Late-Onset Alzheimer's Disease
Schuh, A. F. S., Rieder, C. R. D. M., Rizzi, L., Chaves, M. L. F., & Roriz‐Cruz, M. (2011) · ISRN Neurology · doi:10.5402/2011/306905 · Cited by 34
“Some patterns of neurodegeneration involved in cognitive impairment are highly preserved phylogenetically in mammals—such as reduced synaptic activity in neurons, alterations in glial metabolism, and accumulation of specific metabolic products [3].”
Background
Towards AI-driven longevity research: An overview
Marino, N., Putignano, G., Cappilli, S., Chersoni, E., Chadha, A. S., Calabrese, G., Bischof, E. Y., Vanhaelen, Q., Zhavoronkov, A. A., Scarano, B., et al. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1057204 · Cited by 48
“The main purpose of the network theory of aging was to integrate different mechanisms of aging into a common framework to better understand the systemic consequences of their continuous mutual interactions (Kowald and Kirkwood, 1994; Kowald and Kirkwood, 1996; Franceschi et al., 2000; Slijepcevic, 2008).”
Background
Aging of the human innate immune system in HIV infection
Zapata, H. J., & Shaw, A. C. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.007 · Cited by 35
“Similar increases in neopterin [11], cytokines, coagulation factors, and acute phase reactants [12] have been reported in older, compared to younger, HIV-negative adults; the term “inflamm-ageing” [13,14] was coined to describe this age-associated pro-inflammatory environment.”
Result
Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity
Marini, M., Lapalombella, R., Canaider, S., Farina, A., Monti, D., Vescovi, V. D., Morellini, M., Bellizzi, D., Dato, S., Benedictis, G. D., et al. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.023 · Cited by 34
Self-citation
Genetics of aging, health, and survival: dynamic regulation of human longevity related traits
Yashin, A. I., Wu, D., Arbeeva, L. S., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Kovtun, M., Culminskaya, I. V., Stallard, E., Li, M., et al. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00122 · Cited by 28
Self-citation
Senescence in immune priming and attractiveness in a beetle
Daukšte, J., Kivleniece, I., Krama, T., Rantala, M., & Krams, I. (2012) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2012.02516.x · Cited by 32
“This age-related decline of immune activity is referred to as immunosenescence and has been observed for both the adaptive immune response of vertebrates and the innate immune system of invertebrates (Franceschi et al., 2000; Malaguarnera et al., 2001; Doums et al., 2002; Aspinall et al., 2003).”
Background
Targeting Mediators of Inflammation in Heart Failure: A Short Synthesis of Experimental and Clinical Results
Szabo, T. M., Frigy, A., & Nagy, E. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313053 · Cited by 33
“The relationship between the differentiation of T-cells and proinflammatory cytokines is bidirectional: differentiated T-cell phenotypes increase serum concentrations of proinflammatory proteins, whereas low-grade inflammation is involved in the aging of T-lymphocytes [75].”
Background
Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain
Palomera‐Ávalos, V., Griñán‐Ferré, C., de Izquierdo, V. S., Camins, A., Sanfeliu, C., Canudas, A. M., & Pallàs, M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.014 · Cited by 30
“It is accepted that the main traits of the harmful event gated to aging include the incapacity to confront this event with a variety of stressors and with the inflammaging characteristics defined previously (Franceschi et al., 2000a,b; Leon et al., 2017).”
Background
Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia × Brown Norway/BiNia rat
Asano, S., Rice, K. M., Kakarla, S. K., Katta, A., Desai, D. H., Walker, E. M., Wehner, P. S., & Blough, E. R. (2007) · Redox Report · doi:10.1179/135100007x200254 · Cited by 25
“Although those two theories contain further branches of theories, many of these theories are not mutually exclusive[44].”
Background
Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?
Cannavò, A., Carandina, A., Corbi, G., Tobaldini, E., Montano, N., & Arosio, B. (2022) · Life · doi:10.3390/life12122139 · Cited by 29
“Overall, the physiological changes that portray old people are the results of each individual’s adaptive strategies from a biological point of view [21], balancing the physiological decline that occurs during aging.”
Background
The Frailty Index in centenarians and their offspring
Arosio, B., Ferri, E., Casati, M., Mari, D., Vitale, G., & Cesari, M. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01283-7 · Cited by 35
Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice
Wong, Y. T., Gruber, J., Jenner, A. M., Tay, F. E. H., & Ruan, R. (2010) · AGE · doi:10.1007/s11357-010-9174-4 · Cited by 25
“Studies have shown that centenarians largely escaped major age-related diseases (Bonafe et al. 2001) that are characterized by a complex remodeling of immune responses ( Franceschi et al. 2000b ).”
Background
NEMO shuttle: A link between DNA damage and NF-κB activation in progeroid syndromes?
Salminen, A., Suuronen, T., Huuskonen, J., & Kaarniranta, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.189 · Cited by 27
“This supports a role for the inflamm-aging process in aging [37].”
Circulating progenitor cells and the elderly: A seven-year observational study
Mandraffino, G., Sardo, M. A., Riggio, S., D’Ascola, A., Alibrandi, A., Saitta, C., Versace, A. G., Castaldo, M., Mormina, E., Imbalzano, E., et al. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.03.007 · Cited by 24
Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case–control approach (APOE and HSP70.1 loci)
Dato, S., Carotenuto, L., & BENEDICTIS, G. D. (2006) · Biogerontology · doi:10.1007/s10522-006-9030-1 · Cited by 27
Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction
Rattan, S. I. S., & Demirovic, D. (2010) · Springer eBooks · doi:10.1007/978-90-481-8556-6_13 · Cited by 21
“However, this inflammatory SR, over a longer time scale becomes chronic inflammation, which is considered to be one of the major causes of aging and age-related diseases (Franceschi et al. 2000).”
Background
Cloning of differentially expressed genes in skin fibroblasts from centenarians
Chondrogianni, N., Simoes, D. C. M., Franceschi, C., & Gonos, E. S. (2004) · Biogerontology · doi:10.1007/s10522-004-3188-1 · Cited by 25
“Of those subjects, healthy centenarians represent the best example of successful aging and longevity since, despite being extremely old, they show a drastically reduced occurrence of ageassociated diseases and most of them are in good mental and physical condition (reviewed in Franceschi et al. 2000 ).”
BackgroundSelf-citation
Thyroid hormones and frailty in persons experiencing extreme longevity
Arosio, B., Monti, D., Mari, D., Passarino, G., Ostan, R., Ferri, E., Rango, F. D., Franceschi, C., Cesari, M., & Vitale, G. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111000 · Cited by 27
Self-citation
Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging
Ebersole, J. L., Kirakodu, S. S., Novak, M. J., Orraca, L., González‐Martínez, J., Cunningham, L. L., Thomas, M. V., Stromberg, A. J., Pandruvada, S. N. M., & González, O. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00272 · Cited by 26
Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects
Ostan, R., Alberti, S., Bucci, L., Salvioli, S., Pasi, S., Cevenini, E., Capri, M., Iorio, A. D., Ginaldi, L., Martinis, M. D., et al. (2006) · Biogerontology (Dordrecht) · doi:10.1007/s10522-006-9059-1 · Cited by 25
“Immunosenescence is characterized by a complex and profound remodelling of the immune system, mainly driven by lifelong antigenic burden (Franceschi et al. 2000).”
BackgroundSelf-citation
A Stochastic Model for CD8+T Cell Dynamics in Human Immunosenescence: Implications for Survival and Longevity
Luciani, F., Valensin, S., Vescovini, R., Sansoni, P., Fagnoni, F. F., Franceschi, C., Bonafè, M., & Turchetti, G. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2433 · Cited by 26
“…reinforces the concept that immunosenescence is the ultimate outcome of the continuous lifelong chronic antigenic stress (Franceschi et al., 1999; Franceschi et al., 2000a); 8. finally, the re-exposure of AE CD8+ T cells to antigens, which gives a negative contribution to the ANE T cell…”
BackgroundResultInfluentialSelf-citation
Vitamin D in physiological and pathological aging: Lesson from centenarians
Ferri, E., Casati, M., Cesari, M., Vitale, G., & Arosio, B. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09522-y · Cited by 23
“The indistinguishable characteristic of this unique population is its huge heterogeneity probably deriving from the combination of individual past histories, lifestyle habits, environmental factors and illnesses affecting lifelong [100] and/or the result of a successful or unsuccessful adaptation, according to the rem…”
Background
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study
Garrido, A., Cruces, J., Ceprián, N., Hernández‐Sánchez, C., & la Fuente, M. D. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.003 · Cited by 27
Microvasculature remodeling in the mouse lower gut during inflammaging
Jeong, J., Kim, K., Lim, D., Kim, K.-H., Kim, H.-S., Lee, S., Song, J., Moon, B.-G., Choy, H. E., & Park, S. C. (2017) · Scientific Reports · doi:10.1038/srep39848 · Cited by 30
What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare data
Yashin, A. I., Arbeev, K. G., Kulminski, A. M., Akushevich, I. V., Akushevich, L., & Ukraintseva, S. V. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.12.005 · Cited by 23
Self-citation
CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer’s Disease
Zhang, X., Zhao, Y.-F., Zhu, S., Huang, W., Luo, Y., Chen, Q.-Y., Ge, L.-J., Li, R., Wang, J., Sun, M., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150041 · Cited by 36
“Inflammation in the central nervous system (CNS), an early event in the pathogenesis of AD, has been proposed to play a role in AD pathology [17–19].”
Background
The association of astrogliosis and microglial activation with aging and Alzheimer’s disease pathology in the chimpanzee brain.
Edler, M. K., Munger, E. L., Maycon, H., Hopkins, W. D., Hof, P. R., Sherwood, C. C., & Raghanti, M. A. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25167 · Cited by 23
Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver
Bellavista, E., Martucci, M., Vasuri, F., Santoro, A., Mishto, M., Kloß, A., Capizzi, E., Degiovanni, A., Lanzarini, C., Remondini, D., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.09.003 · Cited by 26
Self-citation
Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis
Comin, F., Speziali, E., Martins‐Filho, O. A., Caldas, I. R., Moura, V., Gazzinelli, A., Corrêa‐Oliveira, R., & Faria, A. M. C. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03403.x · Cited by 22
Increase of homozygosity in centenarians revealed by a new inter-Alu PCR technique
Bonafè, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00112-7 · Cited by 21
Self-citation
Immunological and non-immunological mechanisms of allergic diseases in the elderly: biological and clinical characteristics
Lorenzo, G. D., Bona, D. D., Belluzzo, F., & Macchia, L. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0105-4 · Cited by 24
“Other observations of the T-cell population with ageing include reduced proliferation responses [6], a decrease in CD8+ T cell levels, a shift of Th1 to Th2 cytokine profiles upon stimulation with phorbol myristic acid, a decline in FAS-mediated T-cell apoptosis [7], and increased DR expression on T-cells.”
Background
Running has a negative effect on bone metabolism and proinflammatory status in male aged rats.
Sipos, W., Rauner, M., Skalicky, M., Viidik, A., Hofbauer, G., Schett, G., Redlich, K., Lang, S., & Pietschmann, P. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.008 · Cited by 22
“Amongst these, a continuous increase of proinflammatory cytokines causes a state termed “inflammaging” (Franceschi et al., 2000a,b; Kovacs, 2005).”
Background
Immunological and immunogenetic markers of successful and unsuccessful ageing
Candore, G., Colonna‐Romano, G., Lio, D., & Caruso, C. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13003-3 · Cited by 23
Possible role of NF-κB in hormesis during ageing
Chirumbolo, S. (2012) · Biogerontology · doi:10.1007/s10522-012-9402-7 · Cited by 19
“This indicates that the entropy related to ageing process activates the innate immunity system (Franceschi et al. 2000).”
Background
From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction
Luca, F. D., Camporeale, V., Leccese, G., Cuttano, R., Troise, D. E., Infante, B., Stallone, G., Netti, G. S., & Ranieri, E. (2025) · Cells · doi:10.3390/cells14221831 · Cited by 23
“However, as damage accumulates, the danger responses can become chronic and hence maladaptive [15].”
Suggestions from Geroscience for the Genetics of Age-Related Diseases
Franceschi, C., & Garagnani, P. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006399 · Cited by 21
Self-citation
The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene)
Tan, Q., Bellizzi, D., Rose, G., Garasto, S., Franceschi, C., Kruse, T. A., Vaupel, J. W., BENEDICTIS, G. D., & Yashin, A. I. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00081-7 · Cited by 19
“Increasing evidence shows that, as in model organisms, the capability to cope with stress in humans is also a leading factor in rate and quality of aging (Franceschi et al., 2000).”
BackgroundSelf-citation
Association between the Inflammatory Potential of the Diet and Biological Aging: A Cross-Sectional Analysis of 4510 Adults from the Moli-Sani Study Cohort
Martínez, C. F., Esposito, S., Castelnuovo, A. F. D., Costanzo, S., Ruggiero, E., Curtis, A. D., Persichillo, M., Hébert, J. R., Cerletti, C., Donati, M. B., et al. (2023) · Nutrients · doi:10.3390/nu15061503 · Cited by 23
“Several mechanisms are involved, including the accumulation of cellular damage [8], changes in the gut and oral microbiota [9], and cellular senescence [10], which causes an”
Background
Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver
Gensous, N., Ravaioli, F., Pirazzini, C., Gramignoli, R., Ellis, E. C. S., Storci, G., Capri, M., Strom, S. C., Laconi, E., Franceschi, C., et al. (2020) · Nutrients · doi:10.3390/nu12020277 · Cited by 21
“Aging is a multi-dimensional, multi-factorial process [4], in which the organism continuously adapts to the progressive accumulation of damage and the decay in maintenance systems that occur over time [5,6].”
BackgroundSelf-citation
UCP3 polymorphisms, hand grip performance and survival at old age: Association analysis in two Danish middle aged and elderly cohorts
Dato, S., Soerensen, M., Montesanto, A., Lagani, V., Passarino, G., Christensen, K., & Christiansen, L. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.06.004 · Cited by 21
“…mitochondrial metabolism involved in muscular functioning: the coordination of these factors into a program responsive to the environment is complex and may represent one of the mechanism used by the aging organism to adapt itself to the new physiological scenario (Franceschi et al., 2000).”

Authors: Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D., & De Benedictis, G.
Affiliations: Istituto Nazionale di Riposo e Cura per Anziani (IT)
University of Bologna (IT)
University of Campania "Luigi Vanvitelli" (IT)
Max Planck Institute for Demographic Research (DE)
University of Florence (IT)
Corresponding author: Franceschi, C
ORCID: Franceschi, C
Bonafè, M
Paolisso, G
Monti, D
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2000-09
Volume: 35
Issue: 6-7
Pages: 879-896
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/s0531-5565(00)00172-8
OpenAlex: W1984265860
Cited by: 335
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 17 · 2020: 14 · 2019: 15 · 2018: 17 · 2017: 23 · 2016: 16 · 2015: 16 · 2014: 15 · 2013: 16 · 2012: 16
FWCI: 3.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords: aging, longevity, centenarians, inflammaging, stress response, inflammation, stress tolerance, unicellular organisms, yeast, Caenorhabditis elegans, mice, human
MeSH terms: Aging, Animals, Biological Evolution, Heat-Shock Proteins, Humans, Immune System, Inflammation, Saccharomyces cerevisiae, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The network and the remodeling theories of aging: historical background and new perspectives

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks