Aging and the human neocortex

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.

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The efficiency of systematic sampling in stereology—reconsidered

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Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

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Unbiased stereological estimation of the number of neurons in the human hippocampus

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Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

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VARIATION WITH AGE IN THE VOLUMES OF GREY AND WHITE MATTER IN THE CEREBRAL HEMISPHERES OF MAN: MEASUREMENTS WITH AN IMAGE ANALYSER

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The total number of neurons in the human neocortex unbiasedly estimated using optical disectors

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Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease

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A quantitative study of cerebral atrophy in old age and senile dementia

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Ageing and the Brain

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Mechanisms of Neuron Loss in Alzheimer’s Disease

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Very Large-Scale Neuromorphic Systems for Biological Signal Processing

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Multimodal MR Imaging Signatures of Cognitive Impairment in Active Professional Fighters

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Intracranial recordings reveal ubiquitous in‐phase and in‐antiphase functional connectivity between homotopic brain regions in humans

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Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N‐methyl‐D‐aspartate receptor activation

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The Effects of Amyloid and Tau on Functional Network Connectivity in Older Populations

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Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases

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Inflammation and Immune System Activation in Aging: A Mathematical Approach

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Genetics of ageing-related changes in brain white matter integrity – A review

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Thalamic volume loss as an early sign of amnestic mild cognitive impairment

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Large-Scale Simulations of Plastic Neural Networks on Neuromorphic Hardware

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Driving reservoir models with oscillations: a solution to the extreme structural sensitivity of chaotic networks

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Ubiquitous Neocortical Decoding of Tactile Input Patterns

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FDG-PET-based brain network analysis: a brief review of metabolic connectivity

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Total Number of Synapses in the Adult Human Neocortex

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White matter changes with age utilizing quantitative diffusion MRI

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Analysis of Age-Related White Matter Microstructures Based on Diffusion Tensor Imaging

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Spray pyrolysis deposited iron tungstate memristive device for artificial synapse application

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Oxidation Proteomics: The Role of Thiol Modifications

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Human Brain Networks in Physiological and Pathological Aging: Reproducibility of Electroencephalogram Graph Theoretical Analysis in Cortical Connectivity

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Age-related reduction in microcolumnar structure correlates with cognitive decline in ventral but not dorsal area 46 of the rhesus monkey

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Size and number of binucleate and mononucleate superior cervical ganglion neurons in young capybaras

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Imposing Biological Constraints onto an Abstract Neocortical Attractor Network Model

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Stochasticity and robustness in spiking neural networks

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Should Alzheimer's disease be equated with human brain ageing?: A maladaptive interaction between brain evolution and senescence

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Genome instability: Linking ageing and brain degeneration

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Synapse-Centric Mapping of Cortical Models to the SpiNNaker Neuromorphic Architecture

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Aging and central vision loss: Relationship between the cortical macro-structure and micro-structure

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Interstellar Communication Network. I. Overview and Assumptions

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Cortical aging – new insights with multiparametric quantitative MRI

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Automatic isotropic fractionation for large-scale quantitative cell analysis of nervous tissue

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Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling

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Neuroglia in the inferior olivary nucleus during normal aging and Alzheimer's disease

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Long-Term Running Exercise Delays Age-Related Changes in White Matter in Rats

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Age-related prefrontal cortex activation in associative memory: An fNIRS pilot study

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Design-Based Stereology in Brain Aging Research

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A voxelwise approach to determine consensus regions-of-interest for the study of brain network plasticity

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Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer’s Disease

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Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains

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Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging

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What would a synthetic connectome look like?

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Effects of aging on the myelination of the optic nerve in rats

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Geometric constraints on neuronal connectivity facilitate a concise synaptic adhesive code

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Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease

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CTT-Based Scalable Neuromorphic Architecture

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Molecular differences in brain regional vulnerability to aging between males and females

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Positive effects of brisk walking and Tai Chi on cognitive function in older adults: An fNIRS study

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Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease

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Somatic mutations – Evolution within the individual

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Widespread synaptic loss in multiple sclerosis

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Brain-inspired computing for in-process melt pool characterization in additive manufacturing

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Ethanol-Induced Alterations in Purkinje Neuron Dendrites in Adult and Aging Rats: a Review

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Towards a Multiscale, High-Resolution Model of the Human Brain

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Biologically Realistic Behaviors From a Superconducting Neuron Model

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Metal-Oxide Heterojunction: From Material Process to Neuromorphic Applications

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Neuronal composition of processing modules in human V1: laminar density for neuronal and non-neuronal populations and a comparison with macaque

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Human Brain Evolution: Ontogeny and Phylogeny

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Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits

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Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging

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Epigenetic Code and Self-Identity

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Word sequence production in cognitive decline: Forward ever, backward never

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Oxygen Vacancy-Induced Synaptic Plasticity in InAlZnO Nanofiber Transistors for Low-Power Neuromorphic Electronics

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Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases

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Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease

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Synaptic transistor with tunable synaptic behavior based on a thermo-denatured polar polymer material

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Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease

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Cognitive Health in Older Adults

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HyperDetect: A Real-Time Hyperdimensional Solution for Intrusion Detection in IoT Networks

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Lost in translation: How neurons cope with tRNA decoding

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Abnormal cortical regions and subsystems in whole brain functional connectivity of mild cognitive impairment and Alzheimer’s disease: a preliminary study

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Simple Connectome Inference from Partial Correlation Statistics in Calcium Imaging

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Interfacing Neural Network Components and Nucleic Acids

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Activity dependent post-tetanic potentiation of starch-based biopolymer electrolyte gated oxide synaptic transistors

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The Developing Left Superior Cervical Ganglion of Pacas (Agouti paca)

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Non-destructive whole-brain monitoring using nanorobots: neural electrical data rate requirements.

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Mathematical definition of"intelligence"(and consequences)

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The in vivo topography of cortical changes in healthy aging and prodromal Alzheimer's disease

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Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

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Adaptive rewiring: a general principle for neural network development

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Unravelling the Alzheimer's pathogenesis: Molecular and cellular pathways to neurodegeneration and therapeutic targets

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Effect of Caloric Restriction on Aging: Fixing the Problems of Nutrient Sensing in Postmitotic Cells?

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Proton Competitive Activities in Flexible Hydrogel Gated Oxide Neuromorphic Transistor for Mimicking Bienenstock– Cooper–Munro Learning Rule

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Programmed to be Human?

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Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability

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Model systems for the study of how symbiotic associations between animals and extracellular bacterial partners are established and maintained

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Rethinking Alzheimer’s disease: The role of age-related changes

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Neuronal Functional Diversity and Collective Behaviors

Sannita, W. G. (2008) · Journal of Biological Physics · doi:10.1007/s10867-008-9097-9 · Cited by 9

Structured Dynamics in the Algorithmic Agent

Ruffini, G., Castaldo, F., & Vohryzek, J. (2025) · Entropy · doi:10.3390/e27010090 · Cited by 11

Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage.

Hutter‐Paier, B., Reininger‐Gutmann, B., Wronski, R., Doppler, E., & Moessler, H. (2015) · PubMed Central · Cited by 8

Brain Networks Modulation in Young and Old Subjects During Transcranial Direct Current Stimulation Applied on Prefrontal and Parietal Cortex

Miraglia, F., Vecchio, F., Pellicciari, M. C., Cespón, J., & Rossini, P. M. (2021) · International Journal of Neural Systems · doi:10.1142/s0129065721500568 · Cited by 9

Quantitative evaluation of brain volume among elderly individuals in São Paulo, Brazil: a population-based study

Rodrigues, M. A. S., Rodrigues, T. P., Zatz, M., Lebrão, M. L., Duarte, Y. A. O., Naslavsky, M. S., do Nascimento, F. B. P., & Amaro, E. (2019) · Radiologia Brasileira · doi:10.1590/0100-3984.2018.0074 · Cited by 8

Towards Cortex Sized Attractor ANN

Johansson, C., & Lansner, A. (2004) · Lecture notes in computer science · doi:10.1007/978-3-540-27835-1_6 · Cited by 8

Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder

Hanson, K. L., Avino, T. A., Taylor, S. L., Murray, K. D., & Schumann, C. M. (2025) · Molecular Autism · doi:10.1186/s13229-025-00684-y · Cited by 9

Physiology of oligodendroglia

Butt, A. M., Niu, J., Yi, C., & Verkhratsky, A. (2026) · Physiological Reviews · doi:10.1152/physrev.00023.2025 · Cited by 7

Neuronal volume of the hippocampal regions in ageing

Delgado‐González, J., de la Rosa‐Prieto, C., Tarruella‐Hernández, D. L., Calcerrada, N. V., Sánchez, S. C., Insausti, R., & Artacho‐Pérula, E. (2020) · Journal of Anatomy · doi:10.1111/joa.13189 · Cited by 7

Neocortical glial cell numbers in human brains

Pelvig, D. P., Pakkenberg, H., Stark, A. K., & Pakkenberg, B. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.013 · Cited by 601

Effect of age on neocortical brain cells in 90+ year old human females—a cell counting study

Fabricius, K., Jacobsen, J. S., & Pakkenberg, B. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.009 · Cited by 89

Neocortical neuron number in humans: Effect of sex and age

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The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex

Castro-Fonseca, E., de Morais, V. A. C., da Silva, C. G., Wollner, J., Freitas, J., Neto, A. F. M., Oliveira, L. E., de Oliveira, V. C., Leite, R. E. P., Alho, A. T. D. L., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad148 · Cited by 9

Cellular Composition in the Aging Cerebral Cortex of Humans

Kalanjati, V. P., Hendrata, W. M., & Ardana, F. N. (2019) · Neurophysiology · doi:10.1007/s11062-020-09838-5 · Cited by 1