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Cited by 2,286Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionAquaculture Nutrition and Growth

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Recovery of microalgal biomass and metabolites: process options and economics

Molina Grima, E, Belarbi, E.-H, Acién Fernández, F.G, Robles Medina, A, Chisti, Yusuf·2003·Biotechnology Advances
DOI 10.1016/s0734-9750(02)00050-2
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Abstract

Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of the crude extract. This review examines the options available for recovery of the biomass and the intracellular metabolites from the biomass. Economics of monoseptic production of microalgae in photobioreactors and the downstream recovery of metabolites are discussed using eicosapentaenoic acid (EPA) recovery as a representative case study.

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Crossref · 10.1016/s0734-9750(02)00050-2

Cites

75 of 75 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 75 references

Research works printed but not linked: 10

  1. Borowitzka, 1986, Microalgae as sources of fine chemicals, Microbiol. Sci., 3, 372
  2. Chisti, 1999, Shear sensitivity, vol. 5, 2379
  3. Cohen, 1957, Natural and synthetic polyelectrolytes as coagulants and coagulant aids, Bull. U. S. Dept. Health, Educ. Welf.
  4. Golueke, 1965, Harvesting and processing sewage grown planktonic algae, J. Water Pollut. Control Fed., 37, 471
  5. Lincoln, 1985, Resource recovery with microalgae, Arch. Hydrobiol., 20, 25
  6. McGarry, 1970, Alga flocculation with aluminium sulfate and polyelectrolytes, J. Water Pollut. Control Fed., 42, R191
  7. Mohn, 1978, Improved technologies for the harvesting and processing of microalgae and their impact on production costs, Arch. Hydrobiol., Beih. Ergeb. Limnol., 1, 228
  8. Ruane, M. Extraction of caroteniferous materials from algae. Australian patent No. 7,239,574 (1977).
  9. Tredici, 1999, Bioreactors, photo, vol. 1, 395
  10. Venkataraman, 1978, New possibility for microalgae production and utilisation in India, Arch. Hydrobiol. Beih., 11, 199

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Metadata

Authors
Molina Grima, E., Belarbi, E.-H., Acién Fernández, F. G., Robles Medina, A., & Chisti, Y.
Affiliations
University of Almería (ES)
ORCID
Belarbi, E.-H
Venue
Biotechnology Advances
Publisher
Elsevier BV
Published
2003-01
Volume
20
Issue
7-8
Pages
491-515
ISSN
0734-9750 (ISSN-L)
DOI
10.1016/s0734-9750(02)00050-2
OpenAlex
W2080024205
Cited by
2,286
References
75
Citations by year
2026: 56 · 2025: 49 · 2024: 78 · 2023: 94 · 2022: 136 · 2021: 146 · 2020: 156 · 2019: 157 · 2018: 143 · 2017: 154 · 2016: 170 · 2015: 183 · 2014: 173 · 2013: 158 · 2012: 146
FWCI
4.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biotechnology Advances (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords
downstream processing, eicosapentaenoic acid, photobioreactors, metabolite purification

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