Cited by 2,286Algal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionAquaculture Nutrition and Growth

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Recovery of microalgal biomass and metabolites: process options and economics

Molina Grima, E, Belarbi, E.-H, Acién Fernández, F.G, Robles Medina, A, Chisti, Yusuf·2003·Biotechnology Advances

DOI 10.1016/s0734-9750(02)00050-2

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Abstract

Commercial production of intracellular microalgal metabolites requires the following: (1) large-scale monoseptic production of the appropriate microalgal biomass; (2) recovery of the biomass from a relatively dilute broth; (3) extraction of the metabolite from the biomass; and (4) purification of the crude extract. This review examines the options available for recovery of the biomass and the intracellular metabolites from the biomass. Economics of monoseptic production of microalgae in photobioreactors and the downstream recovery of metabolites are discussed using eicosapentaenoic acid (EPA) recovery as a representative case study.

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Authors: Molina Grima, E., Belarbi, E.-H., Acién Fernández, F. G., Robles Medina, A., & Chisti, Y.
Affiliations: University of Almería (ES)
ORCID: Belarbi, E.-H
Venue: Biotechnology Advances
Publisher: Elsevier BV
Published: 2003-01
Volume: 20
Issue: 7-8
Pages: 491-515
ISSN: 0734-9750 (ISSN-L)
DOI: 10.1016/s0734-9750(02)00050-2
OpenAlex: W2080024205
Cited by: 2,286
References: 75
Citations by year: 2026: 56 · 2025: 49 · 2024: 78 · 2023: 94 · 2022: 136 · 2021: 146 · 2020: 156 · 2019: 157 · 2018: 143 · 2017: 154 · 2016: 170 · 2015: 183 · 2014: 173 · 2013: 158 · 2012: 146
FWCI: 4.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biotechnology Advances (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords: downstream processing, eicosapentaenoic acid, photobioreactors, metabolite purification

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Recovery of microalgal biomass and metabolites: process options and economics

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