The DOI matches its Crossref record; 83 of the 85 references it cites were found in a registry or an index.
Epidemiology and natural history of atrial fibrillation: clinical implications
Open accessAbstract
With a substantial impact on morbidity and mortality, the growing "epidemic" of atrial fibrillation (AF) intersects with a number of conditions, including aging, thromboembolism, hemorrhage, hypertension and left ventricular dysfunction. Currently, the epidemiology and natural history of AF govern all aspects of its clinical management. The ongoing global investigative efforts toward understanding AF are also driven by epidemiologic findings. New developments, by affecting the natural history of the disease, could eventually alter the nature of decision making in patients with AF. The crucial issue of rate versus rhythm control awaits completion of the AF Follow-up Investigation of Rhythm Management trial. The processes of electrical and structural remodeling that perpetuate AF appear to be reversible. In the era of functional genomics, the molecular basis of this ubiquitous arrhythmia is in the process of being defined. Unraveling the molecular genetics of AF might provide new insights into the structural and electrical phenotypes resulting from genetic mutations and, as such, new approaches to treatment of this arrhythmia at the ion channel and cellular levels. Thus, current adverse trends are superimposed on a background of a rapidly developing knowledge base and potentially exciting new therapeutic options. Consequently, an understanding of the epidemiology and natural history of AF is crucial to the future allocation of resources and the utilization of an expanding range of therapies aimed at reducing the impact of this disease on a changing patient population.
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“In view of the emergence of AF as a ‘growing epidemic’,15, 17 an assessment of the global burden of AF is warranted.”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [15]
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Cites
Atrial fibrillation as an independent risk factor for stroke: the Framingham study
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Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
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Atrial Fibrillation Begets Atrial Fibrillation
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“Overall, this rhythm disorder is implicated in approximately 75,000 strokes per year and is probably the major cause of embolic stroke (28).”
BackgroundAntithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The fiamingham Study
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The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators* (1990) · New England Journal of Medicine · doi:10.1056/nejm199011293232201 · Cited by 1,525
Research works printed but not linked: 1
- Chugh, 1999, Sotalol effects are exaggerated in CHF, J Am Coll Cardiol, 33, 131A
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Sorted by citations
Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study
Chugh, S. S., Havmoeller, R., Narayanan, K., Singh, D., Rienstra, M., Benjamin, E. J., Gillum, R. F., Kim, Y.-H., McAnulty, J. H., Zheng, Z.-J., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.005119 · Cited by 4,506
Self-citationMiyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564
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KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation
Chen, Y.-H., Xu, S.-J., Bendahhou, S., Wang, X.-L., Wang, Y., Xu, W.-Y., Jin, H., Sun, H., Su, X.-Y., Zhuang, Q.-N., et al. (2003) · Science · doi:10.1126/science.1077771 · Cited by 989
Healey, J. S., Baranchuk, A., Crystal, E., Morillo, C. A., Garfinkle, M., Yusuf, S., & Connolly, S. J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.070 · Cited by 822
Metadata
- Authors
- Chugh, S. S., Blackshear, J. L., Shen, W.-K., Hammill, S. C., & Gersh, B. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gersh, Bernard J
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 37
- Issue
- 2
- Pages
- 371-378
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1988911499
- Cited by
- 768
- References
- 85
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 20 · 2023: 20 · 2022: 22 · 2021: 39 · 2020: 28 · 2019: 30 · 2018: 30 · 2017: 35 · 2016: 47 · 2015: 45 · 2014: 40 · 2013: 49 · 2012: 44
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial fibrillation, epidemiology, natural history (disease), thromboembolism, hemorrhage, hypertension, left ventricular dysfunction, aging, electrical remodeling, structural remodeling, molecular genetics, ion channels, antiarrhythmic therapy
- MeSH terms
- Atrial Fibrillation, Cross-Sectional Studies, Electrocardiography, Humans, Risk Factors, Incidence
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