The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis
Open accessAbstract
OBJECTIVES This study was designed to compare the prognostic value of an abnormal troponin level derived from studies of patients with non-ST elevation acute coronary syndromes (ACS). BACKGROUND Risk stratification for patients with suspected ACS is important for determining need for hospitalization and intensity of treatment. METHODS We identified clinical trials and cohort studies of consecutive patients with suspected ACS without ST-elevation from 1966 through 1999. We excluded studies limited to patients with acute myocardial infarction and studies not reporting mortality or troponin results. RESULTS Seven clinical trials and 19 cohort studies reported data for 5,360 patients with a troponin T test and 6,603 with a troponin I test. Patients with positive troponin (I or T) had significantly higher mortality than those with a negative test (5.2% vs. 1.6%, odds ratio [OR] 3.1). Cohort studies demonstrated a greater difference in mortality between patients with a positive versus negative troponin I (8.4% vs. 0.7%, OR 8.5) than clinical trials (4.8% if positive, 2.1% if negative, OR 2.6, p = 0.01). Prognostic value of a positive troponin T was also slightly greater for cohort studies (11.6% mortality if positive, 1.7% if negative, OR 5.1) than for clinical trials (3.8% if positive, 1.3% if negative, OR 3.0, p = 0.2) CONCLUSIONS In patients with non-ST elevation ACS, the short-term odds of death are increased three- to eightfold for patients with an abnormal troponin test. Data from clinical trials suggest a lower prognostic value for troponin than do data from cohort studies.
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1 retracted
The prognostic value of serum troponin T in unstable angina
Cina, V. G., Gök, K., & Kaptanoğlu, B. (1996) · International Journal of Cardiology · doi:10.1016/0167-5273(95)02532-4 · Cited by 14
RetractedMeta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
The Handbook of Research Synthesis.
Howel, D., Cooper, H., & Hedges, L. V. (1995) · Biometrics · doi:10.2307/2533295 · Cited by 3,642
Antman, E. M., Cohen, M., Bernink, P. J. L. M., McCabe, C. H., Horacek, T., Papuchis, G., Mautner, B., Corbalan, R., Radley, D., & Braunwald, E. (2000) · JAMA · doi:10.1001/jama.284.7.835 · Cited by 3,242
The Handbook of Research Synthesis.
Light, R. J., Cooper, H., & Hedges, L. V. (1994) · Journal of the American Statistical Association · doi:10.2307/2291021 · Cited by 1,868
ACC/AHA guidelines for the management of patients with acute myocardial infarction
Committee Members, Ryan, T. J., Anderson, J. L., Antman, E. M., Braniff, B. A., Brooks, N. H., Califf, R. M., Hillis, L. D., Hiratzka, L. F., Rapaport, E., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00392-0 · Cited by 1,850
Missed Diagnoses of Acute Cardiac Ischemia in the Emergency Department
Pope, J. H., Aufderheide, T. P., Ruthazer, R., Woolard, R. H., Feldman, J. A., Beshansky, J. R., Griffith, J. L., & Selker, H. P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004203421603 · Cited by 1,794
Antman, E. M., Tanasijevic, M. J., Thompson, B., Schactman, M., McCabe, C. H., Cannon, C. P., Fischer, G. A., Fung, A. Y., Thompson, C., Wybenga, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351802 · Cited by 1,749
Cardiac Troponin T Levels for Risk Stratification in Acute Myocardial Ischemia
Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., O’Hanesian, M. A., Wagner, G. S., Kleiman, N. S., Harrell, F. E., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351801 · Cited by 1,114
Antman, E. M., McCabe, C. H., Gurfinkel, E. P., Turpie, A. G. G., Bernink, P. J. L. M., Salein, D., Bayes de Luna, A., Fox, K., Lablanche, J.-M., Radley, D., et al. (1999) · Circulation · doi:10.1161/01.cir.100.15.1593 · Cited by 1,052
Cited by
Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations
Vasan, R. S. (2006) · Circulation · doi:10.1161/circulationaha.104.482570 · Cited by 1,212
Morrow, D. A. (2001) · JAMA · doi:10.1001/jama.286.19.2405 · Cited by 656
Prevalence and Determinants of Troponin T Elevation in the General Population
Wallace, T. W., Abdullah, S. M., Drazner, M. H., Das, S. R., Khera, A., McGuire, D. K., Wians, F., Sabatine, M. S., Morrow, D. A., & de Lemos, J. A. (2006) · Circulation · doi:10.1161/circulationaha.105.609974 · Cited by 434
Assomull, R. G., Lyne, J. C., Keenan, N., Gulati, A., Bunce, N. H., Davies, S. W., Pennell, D. J., & Prasad, S. K. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm113 · Cited by 386
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
(2010) · National Academies Press eBooks · doi:10.17226/12869 · Cited by 276
Metadata
- Authors
- Heidenreich, P. A., Alloggiamento, T., McDonald, K. M., Go, A. S., Hlatky, M. A., & Melsop, K.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 38
- Issue
- 2
- Pages
- 478-485
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2128171311
- Cited by
- 406
- References
- 37
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis. https://app.cochat.ai/papers/10.1016/s0735-1097(01)01388-2
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- Heidenreich, P. A., Alloggiamento, T., McDonald, K. M., Go, A. S., Hlatky, M. A., & Melsop, K. (2001). The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis. Journal of the American College of Cardiology. https://doi.org/10.1016/s0735-1097(01)01388-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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