The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Prevalence and Determinants of Troponin T Elevation in the General Population
Open accessAbstract
Background— The prevalence and determinants of cardiac troponin T (cTnT) elevation in the general population are unknown, and the significance of minimally increased cTnT remains controversial. Our objective was to determine the prevalence and determinants of cTnT elevation in a large, representative sample of the general population. Methods and Results— cTnT was measured from stored plasma samples in 3557 subjects of the Dallas Heart Study, a population-based sample. cTnT elevation (≥0.01 μg/L) was correlated with clinical variables and cardiac MRI findings. The sample weight-adjusted prevalence of cTnT elevation in the general population was 0.7%. In univariable analyses, cTnT elevation was associated with older age, black race, male sex, coronary artery calcium by electron beam CT, a composite marker of congestive heart failure (CHF), left ventricular hypertrophy (LVH), diabetes mellitus (DM), and chronic kidney disease (CKD) ( P <0.001 for each). Subjects with minimally increased (0.01 to 0.029 μg/L) and increased (≥0.03 μg/L) cTnT had a similar prevalence of these characteristics. In multivariable logistic regression analysis, LVH, CHF, DM, and CKD were independently associated with cTnT elevation. Conclusions— In the general population, cTnT elevation is rare in subjects without CHF, LVH, CKD, or DM, suggesting that the upper limit of normal for the immunoassay should be <0.01 μg/L. Even minimally increased cTnT may represent subclinical cardiac injury and have important clinical implications, a hypothesis that should be tested in longitudinal outcome studies.
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Apoptosis in Myocytes in End-Stage Heart Failure
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Race and Gender Differences in C-Reactive Protein Levels
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Cited by
Latini, R., Masson, S., Anand, I. S., Missov, E., Carlson, M., Vago, T., Angelici, L., Barlera, S., Parrinello, G., Maggioni, A. P., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.655076 · Cited by 709
Chow, S. L., Maisel, A. S., Anand, I., Bozkurt, B., de Boer, R. A., Felker, G. M., Fonarow, G. C., Greenberg, B., Januzzi, J. L., Kiernan, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000490 · Cited by 601
Mingels, A., Jacobs, L., Michielsen, E., Swaanenburg, J., Wodzig, W., & van Dieijen-Visser, M. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.106427 · Cited by 295
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
(2010) · National Academies Press eBooks · doi:10.17226/12869 · Cited by 276
Engler, R. J. M., Nelson, M. R., Collins Jr., L. C., Spooner, C., Hemann, B. A., Gibbs, B. T., Atwood, J. E., Howard, R. S., Chang, A. S., Cruser, D. L., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118283 · Cited by 169
Metadata
- Authors
- Wallace, T. W., Abdullah, S. M., Drazner, M. H., Das, S. R., Khera, A., McGuire, D. K., Wians, F., Sabatine, M. S., Morrow, D. A., & de Lemos, J. A.
- Venue
- Circulation
- Published
- 2006-04-25
- Volume
- 113
- Issue
- 16
- Pages
- 1958-1965
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2131110345
- Cited by
- 434
- References
- 36
- FWCI
- 19.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wallace, T. W., Abdullah, S. M., Drazner, M. H., Das, S. R., Khera, A., McGuire, D. K., Wians, F., Sabatine, M. S., Morrow, D. A., & de Lemos, J. A. (2006). Prevalence and Determinants of Troponin T Elevation in the General Population. Circulation. https://doi.org/10.1161/circulationaha.105.609974
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