Cited by 867Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

The relationship between obesity and mortality in patients with heart failure

Open access

Horwich, Tamara B, Fonarow, Gregg C, Hamilton, Michele A, MacLellan, W.Robb, Woo, Mary A, Tillisch, Jan H·2001·Journal of the American College of Cardiology

DOI 10.1016/s0735-1097(01)01448-6

Open this paper in CoChat — free account Open PDF

Abstract

Objectives The study aimed to evaluate the role of obesity in the prognosis of patients with heart failure (HF).Background Previous reports link obesity to the development of HF. However, the impact of obesity in patients with established HF has not been studied.Methods We analyzed 1,203 patients with advanced HF followed in a comprehensive HF management program. The patients were subclassified into categories of body mass index (BMI) defined as: underweight BMI <20.7 (n = 164), recommended BMI 20.7 to 27.7 (n = 692), overweight BMI 27.8 to 31 (n = 168) and obese BMI >31 (n = 179). This sample size allows the detection of small effects (0.02), with a power of 0.80 and an alpha level of 0.05 for comparing one-year survival between BMI groups.Results The four BMI groups had similar profiles in terms of ejection fraction (mean 0.22), sodium, creatinine and smoking. The obese and overweight groups had significantly higher rates of hypertension and diabetes, as well as higher levels of cholesterol, triglycerides and low density lipoprotein cholesterol. The four BMI groups had similar survival rates. Ejection fraction, HF etiology and angiotensin-converting enzyme inhibitor use predicted survival on univariate analysis (p < 0.01), although BMI did not. On multivariate analysis, cardiopulmonary exercise tests, pulmonary capillary wedge pressure and serum sodium were strong predictors of survival (p < 0.05). Higher BMI was not a risk factor for increased mortality, but was associated with a trend toward improved survival.Conclusions In a large cohort of patients with advanced HF of multiple etiologies, obesity is not associated with increased mortality and may confer a more favorable prognosis. Further studies need to delineate whether weight loss promotion in medically optimized patients with HF is a worthwhile therapeutic goal.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0735-1097(01)01448-6

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
Hubert, H. B., Feinleib, M., McNamara, P. M., & Castelli, W. P. (1983) · Circulation · doi:10.1161/01.cir.67.5.968 · Cited by 4,241
Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults
Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., & Heath, C. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910073411501 · Cited by 3,643
Wasting as independent risk factor for mortality in chronic heart failure
Anker, S. D., Ponikowski, P. P., Varney, S. J., Chua, T. P., Clark, A. L., Webb-Peploe, K., Harrington, D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07015-8 · Cited by 1,399
Hormones and Hemodynamics in Heart Failure
Schrier, R. W., & Abraham, W. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410806 · Cited by 1,192
Guidelines for Healthy Weight
Willett, W. C., Dietz, W. H., & Colditz, G. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410607 · Cited by 1,137
Criteria for definition of overweight in transition: background and recommendations for the United States
Kuczmarski, R. J., & Flegal, K. M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1074 · Cited by 705
Evolving trends in the epidemiologic factors of heart failure: Rationale for preventive strategies and comprehensive disease management
Massie, B. M., & Shah, N. B. (1997) · American Heart Journal · doi:10.1016/s0002-8703(97)70173-x · Cited by 547
The endotoxin-lipoprotein hypothesis
Rauchhaus, M., Coats, A. J. S., & Anker, S. D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02690-8 · Cited by 544
Impact of a Comprehensive Heart Failure Management Program on Hospital Readmission and Functional Status of Patients With Advanced Heart Failure
Fonarow, G. C., Stevenson, L. W., Walden, J. A., Livingston, N., Steimle, A. E., Hamilton, M. A., Moriguchi, J. D., Tillisch, J. H., & Woo, M. A. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00208-8 · Cited by 541
Self-citation
Obesity and Heart Disease
Eckel, R. H. (1997) · Circulation · doi:10.1161/01.cir.96.9.3248 · Cited by 512

Show all 30 references

Research works printed but not linked: 1

Davos, 2000, Obesity and survival in chronic heart failure, Circulation, 102, I4202

Sorted by citations

Items 101–200 of 866

Leitlinie zur Diagnose und Behandlung der chronischen koronaren Herzerkrankung der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung (DGK)
Dietz, R., & Rauch, B. (2003) · Zeitschrift für Kardiologie · doi:10.1007/s00392-003-0960-1 · Cited by 124
The obesity paradox: weighing the benefit
Doehner, W., Clark, A. L., & Anker, S. D. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp339 · Cited by 123
Adaptation and maladaptation of the heart in obesity
Harmancey, R., Wilson, C. R., & Taegtmeyer, H. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.110031 · Cited by 121
Impact of obesity on the risk of heart failure and survival after the onset of heart failure
Kenchaiah, S., Gaziano, J. M., & Vasan, R. S. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.011 · Cited by 120
The dual roles of obesity in chronic kidney disease: a review of the current literature
Rhee, C., Ahmadi, S., & Kalantar-zadeh, K. (2016) · Current opinion in nephrology and hypertension · doi:10.1097/mnh.0000000000000212 · Cited by 109
Adequate Energy-Protein Intake is Not Enough to Improve Nutritional and Metabolic Status in Muscle-Depleted Patients with Chronic Heart Failure
Aquilani, R., Opasich, C., Gualco, A., Verri, M., Testa, A., Pasini, E., Viglio, S., Iadarola, P., Pastoris, O., Dossena, M., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.09.002 · Cited by 118
Complex interaction of obesity, intentional weight loss and heart failure: a systematic review and meta-analysis
Mahajan, R., Stokes, M. B., Elliott, A. D., Munawar, D. A., Khokhar, K. B., Thiyagarajah, A., Hendriks, J., Linz, D., Gallagher, C., Kaye, D. M., et al. (2019) · Heart · doi:10.1136/heartjnl-2019-314770 · Cited by 120
Role of gender, age and BMI in prognosis of heart failure
Sciomer, S., Moscucci, F., Salvioni, E., Marchese, G., Bussotti, M., Corrà, U., & Piepoli, M. F. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487320961980 · Cited by 120
Obesity and cardiovascular risk
Sharma, A. M. (2003) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(03)00047-9 · Cited by 117
Update on obesity, the obesity paradox, and obesity management in heart failure
Alebna, P. L., Mehta, A., Yehya, A., daSilva‐deAbreu, A., Lavie, C. J., & Carbone, S. (2024) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2024.01.003 · Cited by 120
Dynamics of obesity paradox after stroke, related to time from onset, age, and causes of death
Kim, B. J., Lee, S., Jung, K., Yu, K., Lee, B., & Roh, J. (2012) · Neurology · doi:10.1212/wnl.0b013e318266fad1 · Cited by 114
The Obesity Paradox: Impact of Obesity on the Prevalence and Prognosis of Cardiovascular Diseases
Artham, S. M., Lavie, C. J., Milani, R. V., & Ventura, H. O. (2008) · Postgraduate Medicine · doi:10.3810/pgm.2008.07.1788 · Cited by 113
A ‘Weight-Listing’ Paradox for Candidates of Renal Transplantation?
Schold, J., Srinivas, T., Guerra, G., Reed, A., Johnson, R., Weiner, I. D., Oberbauer, R. W., Harman, J., Hemming, A. W., & Meier-Kriesche, H.-U. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01629.x · Cited by 113
Obesity Paradox in Advanced Kidney Disease: From Bedside to the Bench
Naderi, N., Kleine, C., Park, C., Hsiung, J., Soohoo, M., Tantisattamo, E., Streja, E., Kalantar‐Zadeh, K., & Moradi, H. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.001 · Cited by 113
Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status
Christensen, H. M., Kistorp, C., Schou, M., Keller, N., Zerahn, B., Frystyk, J., Schwarz, P., & Faber, J. O. (2012) · Endocrine · doi:10.1007/s12020-012-9836-3 · Cited by 109
Body Mass Index and Outcomes After Left Ventricular Assist Device Placement
Butler, J., Howser, R. L., Portner, P. M., & Pierson, R. N. (2004) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2004.06.047 · Cited by 109
Reverse Epidemiology in Systolic and Nonsystolic Heart Failure
Güder, G., Frantz, S., Bauersachs, J. K., Allolio, B., Wanner, C., Koller, M., Ertl, G., Angermann, C. E., & Störk, S. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.825059 · Cited by 107
Heart Failure in Hispanics
Vivo, R. P., Krim, S. R., Çevik, C., & Witteles, R. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.037 · Cited by 107
The Heart Failure Overweight/Obesity Survival Paradox
Vest, A. R., Wu, Y., Hachamovitch, R., Young, J. B., & Cho, L. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.06.009 · Cited by 103
Body mass index and all-cause mortality in heart failure patients with normal and reduced ventricular ejection fraction: a dose–response meta-analysis
Zhang, J., Begley, A., Jackson, R., Harrison, M., Pellicori, P., Clark, A. L., & Cleland, J. G. F. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1302-7 · Cited by 103
Obesity and Weight Loss at Presentation of Lung Cancer are Associated with Opposite Effects on Survival
Yang, R., Cheung, M. C., Pedroso, F. E., Byrne, M. M., Koniaris, L. G., & Zimmers, T. A. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2011.04.061 · Cited by 101
Effect of Age and Dialysis Vintage on Obesity Paradox in Long-term Hemodialysis Patients
Vashistha, T., Mehrotra, R., Park, J., Streja, E., Dukkipati, R., Nissenson, A. R., Ma, J. Z., Kovesdy, C. P., & Kalantar‐Zadeh, K. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.07.021 · Cited by 102
Obesity and the Obesity Paradox in Heart Failure
Gupta, P. P., Fonarow, G. C., & Horwich, T. B. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.08.004 · Cited by 101
Self-citation
Absence of Obesity Paradox in Patients with Chronic Heart Failure and Diabetes Mellitus: A Propensity-Matched Study
Adamopoulos, C., Meyer, P., Desai, R. V., Karatzidou, K., Ovalle, F., White, M., Aban, I., Love, T. E., DEEDWANIA, P. C., Anker, S. D., et al. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq159 · Cited by 99
Impact of Dietary Patterns and Interventions on Cardiovascular Health
Zarraga, I. G. E., & Schwarz, E. R. (2006) · Circulation · doi:10.1161/circulationaha.105.603910 · Cited by 98
Direct comparison of serial B-type natriuretic peptide and NT-proBNP levels for prediction of short- and long-term outcome in acute decompensated heart failure
Noveanu, M., Breidthardt, T., Potocki, M., Reichlin, T., Twerenbold, R., Uthoff, H., Socrates, T., Arenja, N., Reiter, M., Meissner, J., et al. (2011) · Critical Care · doi:10.1186/cc9398 · Cited by 98
Pre-Morbid Body Mass Index and Mortality After Incident Heart Failure
Khalid, U., Ather, S., Bavishi, C., Chan, W., Loehr, L. R., Wruck, L. M., Rosamond, W. D., Chang, P. P., Coresh, J., Virani, S. S., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.067 · Cited by 97
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states
Taegtmeyer, H., Beauloye, C., Harmancey, R., & Hue, L. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00854.2012 · Cited by 97
The prognostic value of body mass index and standard exercise testing in male Veterans with congestive heart failure
Lissin, L. W., Gauri, A. J., Froelicher, V. F., Ghayoumi, A., Myers, J., & Giacommini, J. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.126812 · Cited by 94
Obesity and hypertension, heart failure, and coronary heart disease-risk factor, paradox, and recommendations for weight loss.
Artham, S. M., Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009) · PubMed Central · Cited by 94
Reduced Body Weight and Adiposity With a High-Protein Diet Improves Functional Status, Lipid Profiles, Glycemic Control, and Quality of Life in Patients With Heart Failure
Evangelista, L. S., Heber, D., Li, Z., Bowerman, S., Hamilton, M. A., & Fonarow, G. C. (2009) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e31819846b9 · Cited by 92
Self-citation
Serum Adiponectin Level as an Independent Predictor of Mortality in Patients With Congestive Heart Failure
Tamura, T., Furukawa, Y., Taniguchi, R., Sato, Y., Ono, K., Horiuchi, H., Nakagawa, Y., Kita, T., & Kimura, T. (2007) · Circulation Journal · doi:10.1253/circj.71.623 · Cited by 91
Adipose Tissue Biology and Cardiomyopathy
Turer, A. T., Hill, J. A., Elmquist, J. K., & Scherer, P. E. (2012) · Circulation Research · doi:10.1161/circresaha.111.262493 · Cited by 91
Position paper of the European Society of Cardiology–working group of coronary pathophysiology and microcirculation: obesity and heart disease
Badimón, L., Bugiardini, R., Cenko, E., Cubedo, J., Dorobanţu, M., Duncker, D. J., Estruch, R., Miličić, D., Tousoulis, D., Vasiljević, Z., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx181 · Cited by 89
Body composition changes in patients with systolic heart failure treated with beta blockers: A pilot study
Lainščak, M., Keber, I., & Anker, S. D. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.01.061 · Cited by 88
Obesity and kidney disease: hidden consequences of the epidemic
Kovesdy, C. P., Furth, S. L., & Zoccali, C. (2017) · Journal of Nephrology · doi:10.1007/s40620-017-0377-y · Cited by 87
Diabetes mellitus, cachexia and obesity in heart failure: rationale and design of the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF)
von Haehling, S., Lainščak, M., Doehner, W., Ponikowski, P. P., Rosano, G. M. C., Jordan, J., Rozentryt, P., Rauchhaus, M., Karpov, R. S., Va, T., et al. (2010) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-010-0013-3 · Cited by 88
Impact of Cardiorespiratory Fitness on the Obesity Paradox in Patients With Systolic Heart Failure
Clark, A. L., Fonarow, G. C., & Horwich, T. B. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.10.023 · Cited by 89
Self-citation
NT-proBNP has a high negative predictive value to rule-out short-term cardiovascular events in patients with diabetes mellitus
Huelsmann, M., Neuhold, S., Strunk, G., Moertl, D., Berger, R., Prager, R., Abrahamian, H., Riedl, M., Pacher, R., Luger, A., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn334 · Cited by 84
Obesity and kidney disease: Hidden consequences of the epidemic
Kovesdy, C., Furth, S. L., & Zoccali, C. (2017) · Physiology International · doi:10.1556/2060.104.2017.1.9 · Cited by 84
Body Mass Index, Prognosis and Mode of Death in Chronic Heart Failure: Results from the Valsartan Heart Failure Trial
Cicoira, M., Maggioni, A. P., Latini, R., Barlera, S., Carretta, E., Jánosi, A., Soler‐Soler, J., Anand, I. S., Cohn, J. N., & Val-HeFT Investigators (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.10.016 · Cited by 84
Metabolism and the heart: An overview of muscle, fat, and bone metabolism in heart failure
Loncar, G., Fülster, S., von Haehling, S., & POPOVIC, V. M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.09.079 · Cited by 85
Obesity as a prognostic factor in chronic symptomatic heart failure
Bozkurt, B., & Deswal, A. M. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.02.004 · Cited by 83
Exercise Tolerance can Explain the Obesity Paradox in Patients with Systolic Heart Failure: Data from the MECKI Score Research Group
Piepoli, M. F., Corrà, U., Veglia, F., Bonomi, A., Salvioni, E., Cattadori, G., Metra, M., Lombardi, C., Sinagra, G., Limongelli, G., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.534 · Cited by 82
Malnutrition, congestion and mortality in ambulatory patients with heart failure
Sze, S., Pellicori, P., Zhang, J., & Clark, A. L. (2018) · Heart · doi:10.1136/heartjnl-2018-313312 · Cited by 81
Overweight, Obesity, and CVD Risk: a Focus on Visceral/Ectopic Fat
Chartrand, D. J., Murphy-Després, A., Alméras, N., Lemieux, I., Larose, É., & Després, J. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-00996-x · Cited by 87
Favorable Functional Recovery in Overweight Ischemic Stroke Survivors: Findings from the China National Stroke Registry
Zhao, L., Du, W., Zhao, X., Liu, L., Wang, C., Wang, Y., Wang, A., Liu, G., Wang, Y., & Xu, Y. (2013) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.10.002 · Cited by 82
Racial and Ethnic Differences in the Association of Body Mass Index and Survival in Maintenance Hemodialysis Patients
Ricks, J., Molnar, M. Z., Kovesdy, C. P., Kopple, J. D., Norris, K. C., Mehrotra, R., Nissenson, A. R., Arah, O. A., Greenland, S., & Kalantar‐Zadeh, K. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.03.023 · Cited by 81
Consequences of obesity and weight loss: a devil's advocate position
Brown, R. E., & Kuk, J. L. (2014) · Obesity Reviews · doi:10.1111/obr.12232 · Cited by 83
Obesity Paradox in Heart Failure: A Heavy Matter
Nagarajan, V., Kohan, L., Holland, E., Keeley, E. C., & Mazimba, S. (2016) · ESC Heart Failure · doi:10.1002/ehf2.12120 · Cited by 82
Factors Associated with Improved Short Term Survival in Obese End Stage Renal Disease Patients
Glanton, C. W., Hypolite, I. O., Hshieh, P., Agodoa, L. Y. C., Yuan, C. M., & Abbott, K. C. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(02)00251-x · Cited by 80
Epidemiology of Dialysis Patients and Heart Failure Patients
Kalantar‐Zadeh, K., Abbott, K. C., Kronenberg, F., Anker, S. D., Horwich, T. B., & Fonarow, G. C. (2006) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2005.09.005 · Cited by 80
Self-citation
The Obesity Paradox and Weight Loss
MYERS, J. N., Lata, K., Chowdhury, S., McAuley, P. A., Jain, N., & Froelicher, V. F. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.018 · Cited by 77
Paradoxical longevity in obese patients with intracerebral hemorrhage
Kim, B. J., Lee, S., Ryu, W., Kim, C. K., Lee, J., & Yoon, B. (2011) · Neurology · doi:10.1212/wnl.0b013e31820b7667 · Cited by 78
Cholesterol levels and in-hospital mortality in patients with acute decompensated heart failure
Horwich, T. B., Hernandez, A. F., Dai, D., Yancy, C. W., & Fonarow, G. C. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.07.004 · Cited by 78
Self-citation
Body Mass, Fitness and Survival in Veteran Patients: Another Obesity Paradox?
McAuley, P. A., MYERS, J. N., Abella, J. P., & Froelicher, V. F. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.07.032 · Cited by 81
Obesity-stroke paradox and initial neurological severity
Kim, Y., Kim, C. K., Jung, S., Yoon, B., & Lee, S. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308664 · Cited by 75
The association between obesity, mortality and filling pressures in pulmonary hypertension patients; the “obesity paradox”
Zafrir, B., Adir, Y., Shehadeh, W., Shteinberg, M., Salman, N., & Amir, O. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.10.019 · Cited by 74
Systolic and Diastolic Heart Failure: Different Phenotypes of the Same Disease?
Keulenaer, G. W. D., & Brutsaert, D. L. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.05.014 · Cited by 73
Obesity and kidney disease: Hidden consequences of the epidemic
Kovesdy, C. P., Furth, S. L., & Zoccali, C. (2017) · Indian Journal of Nephrology · doi:10.4103/ijn.ijn_61_17 · Cited by 73
Effects of intentional weight loss in patients with obesity and heart failure: a systematic review
McDowell, K., Petrie, M. C., Raihan, N. A., & Logue, J. (2018) · Obesity Reviews · doi:10.1111/obr.12707 · Cited by 73
A propensity-matched comparison of survival after lung resection in patients with a high versus low body mass index
Attaran, S., McShane, J., Whittle, I., Poullis, M. P., & Shackcloth, M. J. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezs135 · Cited by 72
The Impact of Obesity in Heart Failure
Carbone, S., Lavie, C. J., Elagizi, A., Arena, R. A., & Ventura, H. O. (2019) · Heart Failure Clinics · doi:10.1016/j.hfc.2019.08.008 · Cited by 78
CARDIOVASCULAR AND SURVIVAL PARADOXES IN DIALYSIS PATIENTS: Reverse Epidemiology beyond Dialysis Patients: Chronic Heart Failure, Geriatrics, Rheumatoid Arthritis, COPD, and AIDS
Horwich, T. B., & Fonarow, G. C. (2007) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2007.00346.x · Cited by 71
Self-citation
Body Mass Index and Outcome After Ventricular Assist Device Placement
Musci, M., Loforte, A., Potapov, E. V., Krabatsch, T., Weng, Y., Pašić, M., & Hetzer, R. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.05.044 · Cited by 72
Predicting Outcome in Patients With Left Ventricular Systolic Chronic Heart Failure Using a Nutritional Risk Index
Al‐Najjar, Y., & Clark, A. L. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.12.026 · Cited by 73
Impact of Bariatric Surgery on Quality of Life, Functional Capacity, and Symptoms in Patients with Heart Failure
Miranda, W. R., Batsis, J. A., Sarr, M. G., Collazo–Clavell, M. L., Clark, M. M., Somers, V. K., & López-Jiménez, F. A. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0953-8 · Cited by 71
Genetic linkage and imprinting effects on body mass index in children and young adults
Gorlova, O. Y., Amos, C. I., Wang, N. W., Shete, S. S., Turner, S. T., & Boerwinkle, E. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200979 · Cited by 70
Anesthetic challenges in the obese patient
Domi, R., & Laho, H. (2012) · Journal of Anesthesia · doi:10.1007/s00540-012-1408-4 · Cited by 71
Moderate overweight is beneficial and severe obesity detrimental for patients with documented atherosclerotic heart disease
Azimi, A., Charlot, M. G., Torp-Pedersen, C. T., Gislason, G., Køber, L., Jensen, L. O., Thayssen, P., Ravkilde, J., Tilsted, H., Lassen, J. F., et al. (2013) · Heart · doi:10.1136/heartjnl-2012-303066 · Cited by 69
Obesity and Stroke: Does the Paradox Apply for Stroke?
Quiñones-Ossa, G. A., Lobo, C., García-Ballestas, E., Florez-Perdomo, W. A., Moscote‐Salazar, L. R., & Agrawal, A. (2021) · Neurointervention · doi:10.5469/neuroint.2020.00108 · Cited by 73
Development and validation of a risk score for hospitalization for heart failure in patients with Type 2 Diabetes Mellitus
Yang, X., Ronald, C. W., So, W., Kong, A. P. S., Ko, G. T. C., Ho, C.-S., Lam, C. W. K., Cockram, C. S., Tong, P. C. Y., & Chan, J. C. N. (2008) · Cardiovascular Diabetology · doi:10.1186/1475-2840-7-9 · Cited by 67
Association of Body Weight and Body Condition with Survival in Dogs with Heart Failure
Slupe, J. L., Freeman, L. M., & Rush, J. E. (2008) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2008.0071.x · Cited by 66
Evaluation of acute congestive heart failure in dogs and cats: 145 cases (2007–2008)
Goutal, C. M., Keir, I., Kenney, S., Rush, J. E., & Freeman, L. M. (2010) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/j.1476-4431.2010.00524.x · Cited by 66
Association Between Adiposity and Lean Mass With Long‐Term Cardiovascular Events in Patients With Coronary Artery Disease: No Paradox
Medina‐Inojosa, J. R., Somers, V. K., Thomas, R. J., Jean, N., Jenkins, S. M., Ibarra, M. A. G., Supervía, M., & López-Jiménez, F. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007505 · Cited by 69
Prognostic Significance of Serum Total Cholesterol and Triglyceride Levels in Patients Hospitalized for Heart Failure With Reduced Ejection Fraction (from the EVEREST Trial)
Greene, S. J., Vaduganathan, M., Lupi, L., Ambrosy, A. P., Mentz, R. J., Konstam, M. A., Nodari, S., Subacius, H. P., Fonarow, G. C., Bonow, R. O., et al. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.10.042 · Cited by 65
Self-citation
Surgical Management of Obesity and the Relationship to Cardiovascular Disease
Vest, A. R., Heneghan, H., Schauer, P. R., & Young, J. B. (2013) · Circulation · doi:10.1161/circulationaha.112.103275 · Cited by 66
Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan - A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) -
Hamaguchi, S., Tsuchihashi‐Makaya, M., Kinugawa, S., Goto, D., Yokota, T., Goto, K., Yamada, S., Yokoshiki, H., Takeshita, A., Tsutsui, H., et al. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0599 · Cited by 69
Obesity Paradox, Cachexia, Frailty, and Heart Failure
Lavie, C. J., Schutter, A. D., Alpert, M., Mehra, M. R., Milani, R. V., & Ventura, H. O. (2014) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.12.002 · Cited by 65
Effect of Orlistat in Obese Patients With Heart Failure: A Pilot Study
Neto, L. B. D. S., Higginson, L., Fraser, M., Williams, K., & Haddad, H. A. (2005) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2005.03827.x · Cited by 64
Cardiac Cachexia Revisited
Valentová, M., Anker, S. D., & von Haehling, S. (2019) · Heart Failure Clinics · doi:10.1016/j.hfc.2019.08.006 · Cited by 69
Measuring Body Composition in Chronic Heart Failure: A Comparison of Methods
Uszko‐Lencer, N. H. M. K., Bothmer-Quaedvlieg, F. C. M., van Pol, P. E. J., & Schols, A. M. W. J. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.07.007 · Cited by 64
Body mass index, body fat, and nutritional status of patients with heart failure: The PLICA study
Gastelurrutia, P., Lupón, J., de Antonio, M., Zamora, E., Domingo, M., Urrútia, A., Altimir, S., Coll, R., Díez, C., & Bayés‐Genís, A. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.12.013 · Cited by 62
Self-care practices in women with diastolic heart failure
GARY, R. A. (2006) · Heart & Lung · doi:10.1016/j.hrtlng.2005.04.005 · Cited by 62
Obesity and cardiovascular risk
Kotsis, V., Tsioufis, K. P., Antza, C., Seravalle, G., Coca, A., Sierra, C., Lurbe, E., Stabouli, S., Jelaković, B., Redón, J., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001731 · Cited by 66
Obesity and Heart Failure — Risk Factor or Mechanism?
Massie, B. M. (2002) · New England Journal of Medicine · doi:10.1056/nejme020065 · Cited by 62
Diagnosis and management of malnutrition in patients with heart failure
Esteban-Fernández, A., Villar-Taibo, R., Alejo, M., Arroyo, D., Bonilla Palomas, J. L., Cachero, M., Joaquin, C., Méndez Bailón, M., Pérez-Rivera, J. Á., Romero-Vigara, J. C., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093320 · Cited by 61
Effect of Body Mass Index on Left Ventricular Cavity Size and Ejection Fraction
Dorbala, S., Crugnale, S. E., Yang, D. D., & Carli, M. F. D. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.09.122 · Cited by 59
Body mass index in adult congenital heart disease
Brida, M., Dimopoulos, K., Kempny, A., Liodakis, E., Alonso-González, R., Swan, L., Uebing, A. S., Baumgartner, H., Gatzoulis, M. Α., & Diller, G. (2017) · Heart · doi:10.1136/heartjnl-2016-310571 · Cited by 61
Causes and consequences of the reverse epidemiology of body mass index in dialysis patients
Kalantar‐Zadeh, K. (2005) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2004.09.020 · Cited by 61
Protective overweight in cardiovascular disease: moving from ‘paradox’ to ‘paradigm’
Doehner, W., von Haehling, S., & Anker, S. D. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv414 · Cited by 61
Understanding Amino-Terminal Pro–B-Type Natriuretic Peptide in Obesity
Bayés‐Genís, A., deFilippi, C. R., & Januzzi, J. L. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.030 · Cited by 58
Impact of Obesity on the Risk of Heart Failure and Its Prognosis
Artham, S. M., Lavie, C. J., Patel, H. M., & Ventura, H. O. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00001.x · Cited by 59
The ‘obesity paradox’ does exist in patients undergoing transcatheter aortic valve implantation for aortic stenosis: a systematic review and meta-analysis
Lv, W., Li, S., Liao, Y., Zhao, Z., Che, G., Chen, M., & Feng, Y. (2017) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivx191 · Cited by 57
Relationship Between Mortality and BMI After Fracture: A Population-Based Study of Men and Women Aged ≥40 Years
Prieto‐Alhambra, D., Premaor, M. O., Avilés, F. F., Soria-Castro, A., Javaid, M. K., Nogués, X., Arden, N., Cooper, C. C., Compston, J. E., & Díez‐Pérez, A. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2209 · Cited by 59
Implications of obesity across the heart failure continuum
Elagizi, A., Carbone, S., Lavie, C. J., Mehra, M. R., & Ventura, H. O. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.09.005 · Cited by 64
Body Mass Index is a Useful Predictor of Prognosis After Left Ventricular Assist System Implantation
Mano, A., Fujita, K., Uenomachi, K., Kazama, K., Katabuchi, M., Wada, K., Terakawa, N., Arai, K., Hori, Y., Hashimoto, S., et al. (2009) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2008.12.020 · Cited by 58
Is Brain Natriuretic Peptide Production Decreased in Obese Subjects?
van Kimmenade, R. R. J., van Dielen, F. M. H., Bakker, J. A., Nijhuis, J., Crijns, H. J. G. M., Buurman, W. A., van Dieijen‐Visser, M. P., Greve, J.-W. M., & Pinto, Y. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.11.022 · Cited by 58
Obesity paradox in Japanese patients after percutaneous coronary intervention: An observation cohort study
Kaneko, H., Yajima, J., Oikawa, Y., Tanaka, S., Fukamachi, D., Suzuki, S. S., Sagara, K., Otsuka, T., Matsuno, S., Funada, R., et al. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.02.009 · Cited by 57
Predictors of Noncompliance to Exercise Training in Heart Failure
Corvera‐Tindel, T., Doering, L. V., Gómez, T., & Dracup, K. (2004) · The Journal of Cardiovascular Nursing · doi:10.1097/00005082-200407000-00006 · Cited by 55

Authors: Horwich, T. B., Fonarow, G. C., Hamilton, M. A., MacLellan, W. R., Woo, M. A., & Tillisch, J. H.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Fonarow, Gregg C
ORCID: Horwich, Tamara B
Fonarow, Gregg C
MacLellan, W.Robb
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2001-09
Volume: 38
Issue: 3
Pages: 789-795
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/s0735-1097(01)01448-6
OpenAlex: W2053715742
Cited by: 867
References: 30
Citations by year: 2026: 20 · 2025: 32 · 2024: 32 · 2023: 36 · 2022: 33 · 2021: 33 · 2020: 38 · 2019: 37 · 2018: 41 · 2017: 64 · 2016: 44 · 2015: 25 · 2014: 47 · 2013: 39 · 2012: 39
FWCI: 10.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4336 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: obesity, heart failure, mortality, body mass index, prognosis, survival, cardiopulmonary exercise testing, pulmonary capillary wedge pressure, serum sodium, weight loss, advanced heart failure
MeSH terms: Adult, Exercise Test, Female, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Obesity, Prognosis, Pulmonary Wedge Pressure, Regression Analysis, Body Mass Index

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The relationship between obesity and mortality in patients with heart failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks