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The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block

Open access
Jaeggi, Edgar T, Hamilton, Robert M, Silverman, Earl D, Zamora, Samuel A, Hornberger, Lisa K·2002·Journal of the American College of Cardiology
DOI 10.1016/s0735-1097(01)01697-7
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Abstract

OBJECTIVES We reviewed our institution's experience with isolated (congenital) third-degree atrioventricular block (CAVB) to identify pre- and post-natal predictors of mortality and the requirement for pacemakers in infancy and childhood. BACKGROUND Because of the relative rarity of the disease, there is a paucity of data concerning the outcome of fetuses and children with isolated CAVB. METHODS The medical records of all cases of CAVB encountered at our institution from January 1965 to December 1998 were analyzed. RESULTS Of 102 cases identified, 29 were diagnosed in utero (F) at 26.1 +/- 5.6 weeks gestation, 33 as neonates (N; < or = 28 days), and 40 as children (C) at 5.7 +/- 4.8 years of age. Anti-Ro and/or anti-La were present in 95% of F and 90% of N, but only in 5% of C mothers tested (p < 0.0001). Patients with CAVB having F, N and C diagnosis had a mortality of 43%, 6% and 0%, respectively, in the first two decades of life. Increased mortality risk was associated with a fetal diagnosis of CAVB (13/15 deaths; p < 0.05), fetal hydrops (6/6 cases; p < 0.0001), endocardial fibroelastosis (5/5 cases; p < 0.0001) and delivery at < or = 32 weeks (4/6 cases; p < 0.05). Timing of pacemaker implantation differed significantly among F versus N (p < 0.05) and N versus C (p < 0.001) cases. At 20 years of age only 11% and 12% of CAVB patients with N and C diagnosis, respectively, were not paced. CONCLUSIONS Pre-natal diagnosis of CAVB is associated with high fetal and neonatal mortality. Among survivors, whether the diagnosis is made before or after birth, most undergo pacemaker implantation by adulthood, with earlier intervention and a significantly greater need for reintervention among those diagnosed in utero.

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Metadata

Authors
Jaeggi, E. T., Hamilton, R. M., Silverman, E. D., Zamora, S. A., & Hornberger, L. K.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2002-01
Volume
39
Issue
1
Pages
130-137
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/s0735-1097(01)01697-7
OpenAlex
W2167179575
Cited by
420
References
18
FWCI
8.51
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block. https://app.cochat.ai/papers/10.1016/s0735-1097(01)01697-7
The paper
Jaeggi, E. T., Hamilton, R. M., Silverman, E. D., Zamora, S. A., & Hornberger, L. K. (2002). Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block. Journal of the American College of Cardiology. https://doi.org/10.1016/s0735-1097(01)01697-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.