The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cerebral blood flow velocity declines before arterial pressure in patients with orthostatic vasovagal presyncope
Open accessAbstract
Objectives We studied hemodynamic changes leading to orthostatic vasovagal presyncope to determine whether changes of cerebral artery blood flow velocity precede or follow reductions of arterial pressure. Background Some evidence suggests that disordered cerebral autoregulation contributes to the occurrence of orthostatic vasovagal syncope. We studied cerebral hemodynamics with transcranial Doppler recordings, and we closely examined the temporal sequence of changes of cerebral artery blood flow velocity and systemic arterial pressure in 15 patients who did or did not faint during passive 70 degrees head-up tilt. Methods We recorded photoplethysmographic arterial pressure, RR intervals (electrocardiogram) and middle cerebral artery blood flow velocities (mean, total, mean/RR interval; Gosling's pulsatility index; and cerebrovascular resistance [mean cerebral velocity/mean arterial pressure, MAP]). Results Eight men developed presyncope, and six men and one woman did not. Presyncopal patients reported light-headedness, diaphoresis, or a sensation of fatigue 155 s (range: 25 to 414 s) before any cerebral or systemic hemodynamic change. Average cerebral blood flow velocity (CBFV) changes (defined by an iterative linear regression algorithm) began 67 s (range: 9 to 198 s) before reductions of MAP. Cerebral and systemic hemodynamic measurements remained constant in nonsyncopal patients. Conclusions Presyncopal symptoms and CBFV changes precede arterial pressure reductions in patients with orthostatic vasovagal syncope. Therefore, changes of cerebrovascular regulation may contribute to the occurrence of vasovagal reactions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Research on orthostatically elicited vasovagal syncopes has shown fainting without sharp drops in blood pressure and heart rate.
“Research on orthostatically elicited vasovagal syncopes has shown fainting without sharp drops in BP and HR (e.g., Dan et al., 2002).”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Dan et al., 2002
The Results report two patients with presyncopal symptoms and heart-rate increases, so a fall in heart rate was not universal. But the study examined presyncope rather than confirmed fainting, and it reports falling arterial pressure—including marked reductions in some patients. It does not establish fainting without sharp drops in both blood pressure and heart rate. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSome studies suggest that drops in heart rate or blood pressure may lag considerably behind the onset of hyperventilation or cerebral blood flow reductions.
“Some studies suggest that drops in HR or BP may lag considerably behind the onset of hyperventilation (see 4.1.1 and 4.2.1) or CBF reductions (Dan et al., 2002).”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Dan et al., 2002
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vagal and sympathetic mechanisms in patients with orthostatic vasovagal syncope
Morillo, C. A., Eckberg, D. L., Ellenbogen, K. A., Beightol, L. A., Hoag, J. B., Tahvanainen, K. U. O., Kuusela, T. A., & Diedrich, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.8.2509 · Cited by 280
Self-citation
Flagged first, then by citations
Research works printed but not linked: 16
- Sutton, 1995, The clinical spectrum of neurocardiogenic syncope, J Cardiovasc Electrophysiol, 6, 569, 10.1111/j.1540-8167.1995.tb00429.x · DOI
- Calkins, 1993, The economic burden of unrecognized vasodepressor syncope, Am J Med, 95, 473, 10.1016/0002-9343(93)90329-N · DOI
- Mosqueda-Garcia, 1997, Sympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt, J Clin Invest, 99, 2736, 10.1172/JCI119463 · DOI · Paper page
- Töyry, 1997, Regional cerebral perfusion in cardiovascular reflex syncope, Eur J Nucl Med, 24, 215, 10.1007/BF02439557 · DOI
- Colier, 1997, Cerebral and circulatory haemodynamics before vasovagal syncope induced by orthostatic stress, Clin Physiol, 17, 83, 10.1046/j.1365-2281.1997.01414.x · DOI
- Grubb, 1991, Cerebral vasoconstriction during head-upright tilt-induced vasovagal syncope. A paradoxic and unexpected response, Circulation, 84, 1157, 10.1161/01.CIR.84.3.1157 · DOI
- Schondorf, 1997, Cerebrovascular and cardiovascular measurements during neurally mediated syncope induced by head-up tilt, Stroke, 28, 1564, 10.1161/01.STR.28.8.1564 · DOI
- Imholz, 1998, Fifteen years’ experience with finger arterial pressure monitoring, Cardiovasc Res, 38, 605, 10.1016/S0008-6363(98)00067-4 · DOI
- Eckberg, 1979, Carotid baroreflex function in young men with borderline blood pressure elevation, Circulation, 59, 632, 10.1161/01.CIR.59.4.632 · DOI
- Jones, 1984, A statistical method for determining the breakpoint of two lines, Analyt Biochem, 141, 287, 10.1016/0003-2697(84)90458-5 · DOI
- van Lieshout, 1991, The vasovagal response, Clin Sci, 81, 575, 10.1042/cs0810575 · DOI · Paper page
- Kontos, 1989, Validity of cerebral arterial blood flow calculations from velocity measurements, Stroke, 20, 1, 10.1161/01.STR.20.1.1 · DOI
- Levine, 1994, Cerebral versus systemic hemodynamics during graded orthostatic stress in humans, Circulation, 90, 298, 10.1161/01.CIR.90.1.298 · DOI · Paper page
- Lindegaard, 1987, Variations in middle cerebral artery blood flow investigated with noninvasive transcranial blood velocity measurements, Stroke, 18, 1025, 10.1161/01.STR.18.6.1025 · DOI
- Schadt, 1991, Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals, Am J Physiol, 260, H305
- Bondar, 1995, Simultaneous cerebrovascular and cardiovascular responses during presyncope, Stroke, 26, 1794, 10.1161/01.STR.26.10.1794 · DOI
Cited by
Sorted by citations
The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm
Ritz, T., Meuret, A. E., & Ayala, E. S. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.007 · Cited by 74
“Some studies suggest that drops in HR or BP may lag considerably behind the onset of hyperventilation (see 4.1.1 and 4.2.1) or CBF reductions (Dan et al., 2002).”
BackgroundInfluential
Metadata
- Authors
- Dan, D., Hoag, J. B., Ellenbogen, K. A., Wood, M. A., Eckberg, D. L., & Gilligan, D. M.
- Affiliations
- Virginia Commonwealth University (US)
- Hunter Holmes McGuire VA Medical Center (US)
- Corresponding author
- Eckberg, Dwain L
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 39
- Issue
- 6
- Pages
- 1039-1045
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2081821432
- Cited by
- 50
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 2 · 2020: 1 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- presyncope, cerebral blood flow velocity, cerebral autoregulation, cerebrovascular resistance, middle cerebral artery, blood pressure reduction, head-up tilt, lightheadedness, photoplethysmography, transcranial Doppler
- MeSH terms
- Blood Flow Velocity, Blood Pressure, Cerebral Arteries, Cerebrovascular Circulation, Female, Heart Conduction System, Humans, Hypotension, Orthostatic, Isoproterenol, Male, Middle Aged, Sympathomimetics, Time Factors, Vascular Resistance, Ultrasonography, Doppler, Transcranial, Syncope, Vasovagal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
