The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The vasovagal response
Abstract
The vasovagal response is the development of inappropriate cardiac slowing and arteriolar dilatation. Vasovagal responses reflect autonomic neural changes: bradycardia results from sudden augmentation of efferent vagal activity, and hypotension results from sudden reduction or cessation of sympathetic activity and relaxation of arterial resistance vessels. Two different neural pathways are thought to be involved, one originating in the hypothalamus, the other in the heart. Direct hypothalamic activation of the medullary cardiovascular centres triggered by emotional stress or pain causes a vasovagal response (central type). The combination of a reduced central blood volume secondary to venous pooling or blood loss, and an increased inotropic state of the heart, may stimulate ventricular mechanoreceptors and provoke vasodilatation and bradycardia (peripheral type). Cardiovascular afferents originating from stretch receptors in various parts of the vascular tree sometimes induce opposite reflexes when compared with those from ventricular afferents. The depressor reflex involved in the peripheral type of vasovagal response originates in the heart itself and overrides normal baroreflex circulatory control; an antagonism between the control of volume and pressure on the filling side of the heart and the control system of arterial pressure becomes apparent. Vasovagal responses are not necessarily abnormal; the neural pathways involved in the vasovagal response are probably present i…
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Research using orthostatic stress paradigms with patients suffering from neurally mediated syncope has substantiated these observations by finding bradycardic and vasodepressor as well as mixed types of syncope.
“Research using orthostatic stress paradigms (e.g., tilt-table testing) with patients suffering from neurally mediated syncope has substantiated these observations by finding bradycardic and vasodepressor as well as mixed types of syncope (Van Lieshout et al., 1991; 1997).”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Van Lieshout et al., 1991
Most evidence on humoral factors is from orthostatic stress testing, with some studies finding decreases in noradrenaline and/or increases in adrenaline leading up to or following syncope.
“Again, most evidence is available from orthostatic stress testing, with some studies finding decreases in noradrenaline and/or increases in adrenaline leading up to or following syncope (Van Lieshout et al., 1991; 1997).”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Van Lieshout et al., 1991
Citations
Cites
Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death
Davies, M. J., & Thomas, A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101801 · Cited by 1,694
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794
Pancreatic Polypeptide: A Hormone Under Vagal Control
Schwartz, T. W. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80027-4 · Cited by 426
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The elusive pathophysiology of neurally mediated syncope
Mosqueda-Garcia, R., Furlan, R., MD, J. T., & Fernandez-Violante, R. (2000) · Circulation · doi:10.1161/01.cir.102.23.2898 · Cited by 383
Management of Vasovagal Syncope: Controlling or Aborting Faints by Leg Crossing and Muscle Tensing
Krediet, C. T. P., van Dijk, N., Linzer, M., van Lieshout, J. J., & Wieling, W. (2002) · Circulation · doi:10.1161/01.cir.0000030939.12646.8f · Cited by 372
Self-citationGANZEBOOM, K. S., MAIRUHU, G., REITSMA, J. B., LINZER, M., WIELING, W., & VAN DIJK, N. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00595.x · Cited by 375
Self-citationDi Girolamo, E., Di Iorio, C., Sabatini, P., Leonzio, L., Barbone, C., & Barsotti, A. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00694-9 · Cited by 322
Effectiveness of Physical Counterpressure Maneuvers in Preventing Vasovagal Syncope
van Dijk, N., Quartieri, F., Blanc, J.-J., Garcia-Civera, R., Brignole, M., Moya, A., & Wieling, W. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.059 · Cited by 315
Self-citationVagal and sympathetic mechanisms in patients with orthostatic vasovagal syncope
Morillo, C. A., Eckberg, D. L., Ellenbogen, K. A., Beightol, L. A., Hoag, J. B., Tahvanainen, K. U. O., Kuusela, T. A., & Diedrich, A. M. (1997) · Circulation · doi:10.1161/01.cir.96.8.2509 · Cited by 280
Self-citationSymptoms and signs of syncope: a review of the link between physiology and clinical clues
Wieling, W., Thijs, R. D., van Dijk, N., Wilde, A. A. M., Benditt, D. G., & van Dijk, J. G. (2009) · Brain · doi:10.1093/brain/awp179 · Cited by 265
Self-citationSympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt
Mosqueda-Garcia, R., Furlan, R., Fernandez-Violante, R., Desai, T., Snell, M., Jarai, Z., Ananthram, V, Robertson, R. M., & Robertson, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119463 · Cited by 255
Midodrine: a role in the management of neurocardiogenic syncope
Ward, C. R., Gray, J. C., Gilroy, J. J., & Kenny, R. A. (1998) · Heart · doi:10.1136/hrt.79.1.45 · Cited by 249
Trouern‐Trend, J. J., Cable, R. G., Badon, S. J., Newman, B. H., & Popovsky, M. A. (1999) · Transfusion · doi:10.1046/j.1537-2995.1999.39399219291.x · Cited by 208
Isometric arm counter-pressure maneuvers to abort impending vasovagal syncope
Brignole, M., Croci, F., Menozzi, C., Solano, A., Donateo, P., Oddone, D., Puggioni, E., & Lolli, G. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02683-9 · Cited by 208
The epidemic of orthostatic tachycardia and orthostatic intolerance
Robertson, D. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40480-x · Cited by 293
Fenton, A. M., Hammill, S. C., Rea, R. F., Low, P. A., & Shen, W.-K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-9-200011070-00014 · Cited by 158
Donor reactions and injuries from whole blood donation
Newman, B. H. (1997) · Transfusion Medicine Reviews · doi:10.1016/s0887-7963(97)80011-9 · Cited by 125
Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial
Karan, N. B. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112676 · Cited by 104
The origin of vasovagal syncope: to protect the heart or to escape predation?
Alboni, P., Alboni, M., & Bertorelle, G. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-008-0479-7 · Cited by 93
Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope
Jardine, D. L., Melton, I. C., Crozier, I. G., English, S., Bennett, S. I., Frampton, C. M., & Ikram, H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00640.2001 · Cited by 86
The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm
Ritz, T., Meuret, A. E., & Ayala, E. S. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.007 · Cited by 74
“Again, most evidence is available from orthostatic stress testing, with some studies finding decreases in noradrenaline and/or increases in adrenaline leading up to or following syncope (Van Lieshout et al., 1991; 1997).”
BackgroundResultInfluentialExercise induced vasodepressor syncope
Sneddon, J. F., Scalia, G., Ward, D. E., McKenna, W. J., Camm, A. J., & Frenneaux, M. P. (1994) · Heart · doi:10.1136/hrt.71.6.554 · Cited by 61
Orthostatic intolerance and the headache patient
Mack, K. J., Johnson, J. N., & Rowe, P. C. (2010) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2010.04.006 · Cited by 47
Neurally mediated cardiac syncope: autonomic modulation after normal saline infusion
Burklow, T. R., Moak, J. P., Bailey, J. J., & Makhlouf, F. T. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00133-3 · Cited by 39
SANTOS, R. Q. D., SMIDT, L., SUZIGAN, B. H., DE SOUZA, L. V., & BARBISAN, J. N. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12069 · Cited by 9
Metadata
- Authors
- van Lieshout, J. J., Wieling, W., Karemaker, J. M., & Eckberg, D. L.
- Affiliations
- Department of Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
- Amsterdam UMC Location University of Amsterdam (NL)
- Hunter Holmes McGuire VA Medical Center (US)
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1991-11-01
- Volume
- 81
- Issue
- 5
- Pages
- 575-586
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W174656537
- Cited by
- 323
- References
- 3
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 2 · 2023: 9 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 4 · 2012: 10
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- vasovagal reaction, bradycardia, hypotension, vagal efferent activity, sympathetic activity, hypothalamic activation, depressor reflex, baroreflex, venous pooling, blood loss, emotional stress, pain, autonomic nervous system, individual susceptibility
- MeSH terms
- Arterioles, Blood Pressure, Heart Rate, Hemodynamics, Humans, Male, Neural Pathways, Reflex, Shock, Stress, Psychological, Syncope, Vagus Nerve, Vasodilation, Vasopressins
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