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Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography
Open accessAbstract
Serum levels of DHEA sulfate are inversely associated with cardiovascular death in men, and urinary dehydroepiandrosterone (DHEA) levels are inversely associated with clinical manifestations of coronary artery disease. These observations may be related to the antiproliferative effects of DHEA, resulting in inhibition of atherosclerotic intimal hyperplasia. To examine the relation between these steroids and a direct measure of coronary atherosclerosis, plasma DHEA and DHEA sulfate levels were determined in 206 middle-aged patients (103 men, 103 women) undergoing elective coronary angiography. Plasma DHEA sulfate levels were lower in men with at least one stenosis greater than or equal to 50% compared with those without any stenosis greater than or equal to 50% (4.9 +/- 2.7 versus 6.1 +/- 3.5 nmol/ml, p = 0.05). Levels of DHEA sulfate were also inversely related to the number of diseased coronary vessels (r = -0.20, p = 0.05) and a continuous measure of the extent of coronary atherosclerosis (r = -0.25, p = 0.01) in men. The association between DHEA sulfate levels and extent of coronary artery disease was independent of age and other conventional risk factors for coronary disease. In women, there was no association between plasma DHEA or DHEA sulfate levels and coronary disease. These data demonstrate a consistent, independent, inverse, dose-response relation between plasma DHEA sulfate levels and angiographically defined coronary atherosclerosis in men. Plasma DHEA sulfate may be another important and potentially modifiable risk factor for the development and progression of coronary atherosclerosis.
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“Low levels of both DHEA and DHEA-S are associated with elevated risk of cardiovascular disease.98-100”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [100]
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Metadata
- Authors
- Herrington, D. M., Gordon, G. B., Achuff, S. C., Trejo, J. F., Weisman, H. F., Kwiterovich, P. O., & Pearson, T. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Herrington, David M.
- ORCID
- Herrington, David M.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1990-10
- Volume
- 16
- Issue
- 4
- Pages
- 862-870
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2091187697
- Cited by
- 147
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Andrew W. Mellon Foundation
- Johns Hopkins University
- National Institutes of Health (7t32hl007642-03, 5p01ca044530-13)
- U.S. Public Health Service (31497)
- National Heart, Lung, and Blood Institute (HL07642)
- National Cancer Institute (P01CA44530, CA 44530)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- dehydroepiandrosterone sulfate, dehydroepiandrosterone, coronary artery disease, coronary artery stenosis, sex differences, cardiovascular risk factors, middle-aged adults, coronary angiography
- MeSH terms
- Adult, Coronary Artery Disease, Coronary Vessels, Dehydroepiandrosterone, Female, Humans, Male, Middle Aged, Regression Analysis, Risk Factors, Sex Factors, Stroke Volume, Coronary Angiography, Dehydroepiandrosterone Sulfate
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