CoChat
Sign Up
Cited by 75Hormonal and reproductive studiesAtherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular Health

Dehydroepiandrosterone and coronary atherosclerosis

HERRINGTON, DAVID M.·1995·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1995.tb17387.x-i1
Open this paper in CoChat — free account

Abstract

Tissue culture, animal model, and epidemiologic studies suggest that dehydroepiandrosterone (DEHA) may inhibit atherosclerosis through its potent antiproliferative effects. To examine the relation between DHEA and a direct measure of coronary atherosclerosis, plasma DHEA, and DHEA sulfate (DHEAS) levels were determined in 206 middle-aged patients undergoing coronary angiography. Plasma DHEAS levels were lower in subjects with at least one > or = 50% stenosis than in those with no stenosis > 50% (p = 0.05) and was inversely associated with the number of diseased coronary vessels and the extent of coronary atherosclerosis (p = 0.05 and 0.01, respectively). Cardiac allograft vasculopathy is dominated by abnormal cellular proliferation and, therefore, may be uniquely influenced by DHEA. To study this, 61 cardiac allograft recipients with at least one annual follow-up cardiac catheterization were studied. Plasma levels of total and free DHEA were inversely related to the development of accelerated coronary allograft vasculopathy (p = 0.005 and 0.003, respectively). Furthermore, the time to development of accelerated allograft vasculopathy was shorter in subjects with low levels of total and free DHEA (p = 0.062 and 0.046, respectively). These data suggest that low plasma levels of DHEA may facilitate, and high levels may retard, the development of coronary atherosclerosis and coronary allograft vasculopathy.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.1995.tb17387.x-i1

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
HERRINGTON, D. M.
Affiliations
Atrium Health Wake Forest Baptist (US)
Corresponding author
HERRINGTON, DAVID M.
ORCID
HERRINGTON, DAVID M.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1995-12
Volume
774
Issue
1
Pages
271-280
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1995.tb17387.x-i1
OpenAlex
W2158015610
Cited by
75
References
45
Citations by year
2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
3.90
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4034 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
dehydroepiandrosterone, DHEA sulfate, coronary artery disease, cardiac allograft vasculopathy, coronary artery stenosis, antiproliferative activity, cell proliferation, cardiac allograft recipients, middle-aged patients
MeSH terms
Adult, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Dehydroepiandrosterone, Female, Humans, Male, Middle Aged, Heart Transplantation, Coronary Angiography, Dehydroepiandrosterone Sulfate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review