CoChat
Sign Up
Cited by 414Hormonal and reproductive studiesAdrenal Hormones and DisordersLipoproteins and Cardiovascular Health

Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.

NESTLER, JOHN E., BARLASCINI, CORNELIUS O., CLORE, JOHN N., BLACKARD, WILLIAM G.·1988·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-66-1-57
Open this paper in CoChat — free account

Abstract

To assess the effects of dehydroepiandrosterone (DHEA) on body fat mass, serum lipid levels, and tissue sensitivity to insulin, five normal men were given placebo and five normal men were given oral DHEA [1600 mg/day (554.7 mmol/day)] for 28 days in a randomized, double blind study. In the DHEA group serum DHEA-S levels rose 2.5- to 3.5-fold, and mean (+/- SEM) serum androstenedione rose from 4.3 +/- 0.6 to 8.6 +/- 1.2 nmol/L (P less than 0.004, by paired t test), but serum total testosterone, free testosterone, sex hormone-binding globulin, estradiol, and estrone levels did not change. In the DHEA group the mean percent body fat decreased by 31%, with no change in weight. This suggests that the reduction in fat mass was coupled with an increase in muscle mass. DHEA administration also resulted in a fall in mean serum total cholesterol concentration (4.82 +/- 0.21 vs. 4.48 +/- 0.29 nmol/L; P less than 0.05), which was due almost entirely to a fall of 7.5% in mean serum low density lipoprotein cholesterol (3.21 +/- 0.11 vs. 2.97 +/- 0.14 nmol/L; P less than 0.01). No changes in anthropometric parameters or serum lipid levels occurred in the placebo group. Tissue sensitivity to insulin, assessed by the hyperinsulinemic-euglycemic clamp technique, did not change in either the placebo or DHEA groups. These results suggest that in normal men DHEA administration reduces body fat, increases muscle mass, and reduces serum low density lipoprotein cholesterol levels. Tissue sensitivity to insulin was unaffected by short term DHEA administration.

Integrity signals

Registry

Crossref · 10.1210/jcem-66-1-57

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
NESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G.
Affiliations
Virginia Commonwealth University (US)
ORCID
BARLASCINI, CORNELIUS O.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1988-01
Volume
66
Issue
1
Pages
57-61
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-66-1-57
OpenAlex
W2094493191
Cited by
414
References
16
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 2 · 2014: 9 · 2013: 5 · 2012: 8
FWCI
9.96
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Oregon
  • National Institutes of Health (5t32am007428-04)
  • National Center for Research Resources (RR 00065)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
dehydroepiandrosterone, fat loss, LDL cholesterol, serum lipids, insulin sensitivity, androstenedione, DHEA sulfate, muscle mass, hyperinsulinemic-euglycemic clamp, testosterone, sex hormone-binding globulin, estradiol, healthy men
MeSH terms
Adipose Tissue, Adult, Androgens, Androstenedione, Body Composition, Cholesterol, Dehydroepiandrosterone, Humans, Insulin, Lipids, Lipoproteins, LDL, Cholesterol, LDL, Male, Muscles, Dehydroepiandrosterone Sulfate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review