Intravenous Dofetilide, a Class III Antiarrhythmic Agent, for the Termination of Sustained Atrial Fibrillation or Flutter
Open accessAbstract
OBJECTIVES: This study sought to determine the safety and efficacy of a single bolus of intravenous dofetilide, a pure class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter. BACKGROUND: Dofetilide is a highly selective blocker of the rapid component of the delayed rectifier current causing action potential prolongation. These effects, and preliminary clinical data, suggest that it may be effective in the treatment of atrial fibrillation and flutter. METHODS: Ninety-one patients with sustained atrial fibrillation (75 patients) or flutter (16 patients) were entered into a double-blind, randomized multicenter study of one of two doses of dofetilide (4 or 8 micrograms/kg body weight) or placebo. RESULTS: Dofetilide effectively terminated the arrhythmia in 31% of patients receiving 8 micrograms/kg, a statistically significant difference from those receiving 4 micrograms/kg (conversion rate 12.5%, p < 0.05) or placebo (no conversion, p < 0.01). Patients with atrial flutter had a greater response to dofetilide (54% conversion rate) than those with atrial fibrillation (14.5% conversion rate, p < 0.001). CONCLUSIONS: Intravenous dofetilide can convert sustained atrial fibrillation or flutter to sinus rhythm. However, its efficacy is greater in flutter--a response that contrasts with the poorer response seen with class I agents. This finding potentially represents an important advance in the pharmacologic termination of atrial flutter.
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Dofetilide and ibutilide, pure class III AADs, are very effective for interrupting AFL intravenously, while class Ia and Ic drugs have little or no effect.
“Dofetilide and ibutilide, pure class III AADs, are very effective for interrupting AFL in intravenous administration, while Class Ia and Ic drugs have little or no effect.138 -142,149”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [139]
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Cites
Sanguinetti, M. C., & Jurkiewicz, N. K. (1990) · The Journal of General Physiology · doi:10.1085/jgp.96.1.195 · Cited by 1,466 · see citing works
Coplen, S. E., Antman, E. M., Berlin, J. A., Hewitt, P., & Chalmers, T. C. (1990) · Circulation · doi:10.1161/01.cir.82.4.1106 · Cited by 944 · see citing works
Digoxin for Converting Recent-Onset Atrial Fibrillation to Sinus Rhythm
Falk, R. H., Knowlton, A. A., Bernard, S. A., Gotlieb, N. E., & Battinelli, N. J. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-4-503 · Cited by 335 · see citing works
Self-citationVoltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.
Carmeliet, E. E. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10827-6 · Cited by 322 · see citing works
Capucci, A., Lenzi, T., Boriani, G., Trisolino, G., Binetti, N., Cavazza, M., Fontana, G. A., & Magnani, B. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91392-h · Cited by 227 · see citing works
Levine, J. H., SPEAR, J. F., Guarnieri, T., Weisfeldt, M. L., LANGEN, C. D. D., Becker, L. C., & Moore, E. N. (1985) · Circulation · doi:10.1161/01.cir.72.5.1092 · Cited by 205 · see citing works
Gwilt, M., Arrowsmith, J. E., Blackburn, K. J., Burges, R. A., Cross, P. E., Dalrymple, H. W., & Higgins, A. J. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23172-x · Cited by 187 · see citing works
Tande, P. M., Bjørnstad, H., Yang, T., & Refsum, H. (1990) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199009000-00008 · Cited by 177 · see citing works
Validation of double-spike electrograms as markers of conduction delay or block in atrial flutter
Cosío, F. G., Arribas, F., Barbero, J. M., Kallmeyer, C., & Goicolea, A. (1988) · The American Journal of Cardiology · doi:10.1016/0002-9149(88)91065-x · Cited by 155 · see citing works
Sotalol, hypokalaemia, syncope, and torsade de pointes.
McKibbin, J. K., Pocock, W. A., Barlow, J. B., Millar, R. N. S., & Obel, I. W. P. (1984) · Heart · doi:10.1136/hrt.51.2.157 · Cited by 150 · see citing works
A Comparison of Some Approximate Confidence Intervals for the Binomial Parameter
Ghosh, B. K. (1979) · Journal of the American Statistical Association · doi:10.1080/01621459.1979.10481051 · Cited by 130 · see citing works
Singh, B. N., & Nademanee, K. (1985) · American Heart Journal · doi:10.1016/0002-8703(85)90629-5 · Cited by 125 · see citing works
Bianconi, L., BOCCADAMO, R., Pappalardo, A., Gentili, C., & Pistolese, M. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90530-4 · Cited by 123 · see citing works
El‐Sherif, N., Bekheit, S.-S., & Henkin, R. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90082-x · Cited by 105 · see citing works
Spinelli, W., & Hoffman, B. F. (1989) · Circulation Research · doi:10.1161/01.res.65.6.1565 · Cited by 87 · see citing works
Kingma, J. H., & SUTTORP, M. J. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91079-j · Cited by 87 · see citing works
Kayden, H. J., Brodie, B. B., & Steele, J. M. (1957) · Circulation · doi:10.1161/01.cir.15.1.118 · Cited by 83 · see citing works
Atrial flutter can be terminated by a class III antiarrhythmic drug but not by a class IC drug
CRIJNS, H. J. G. M., VAN GELDER, I. C., KINGMA, J. H., DUNSELMAN, P. H. J. M., GOSSELINK, A. T. M., & LIE, K. I. (1994) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060402 · Cited by 76 · cited 7× · see citing works
“Class IC agents are also documented to have a poor efficacy in terminating atrial flutter (19).”
BackgroundResultInfluentialSUTTORP, M. J., Polak, P. E., Hof, A. W. J. V. ’., Rasmussen, H. S., Dunselman, P. H. J. M., & Kingma, J. H. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90247-v · Cited by 70 · see citing works
Chemical cardioversion of atrial fibrillation with intravenous dofetilide
Sedgwick, M. L., Lip, G. Y. H., Rae, A. P., & Cobbe, S. M. (1995) · International Journal of Cardiology · doi:10.1016/0167-5273(95)02284-4 · Cited by 65 · see citing works
When is QT prolongation antiarrhythmic and when is it proarrhythmic?
Singh, B. N. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90059-3 · Cited by 64 · see citing works
Olshansky, B., Okumura, K., Hess, P. G., Henthorn, R. W., & Waldo, A. L. (1988) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(88)90102-7 · Cited by 57 · see citing works
Reimold, S. C., Chalmers, T. C., Berlin, J. A., & Antman, E. M. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90974-z · Cited by 48 · see citing works
Tham, T., MacLennan, B. A., Burke, M. T., & Harron, D. W. G. (1993) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199303000-00024 · Cited by 45 · see citing works
Class III Antiarrhythmic Action and Inotropy
Mortensen, E., Yang, T., & Refsum, H. (1992) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199202000-00010 · Cited by 31 · see citing works
Crijns, H. J. G. M., Kingma, J. H., Gosselink, A. T. M., & Lie, K. I. (1993) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1993.tb04575.x · Cited by 23 · see citing works
CRIJNS, H. J. G. M., KINGMA, J. H., GOSSELINK, A. T. M., DALRYMPLE, H. W., De LANGEN, C. D. J., & LIE, K. (1993) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1993.tb01283.x · Cited by 18 · see citing works
To prolong refractoriness or to delay conduction (or both)?
Janse, M. J. (1992) · European Heart Journal · doi:10.1093/eurheartj/13.suppl_f.14 · Cited by 17 · see citing works
LYMAN, J. C. (1876) · New England Journal of Medicine · doi:10.1056/nejm187610050951408 · Cited by 13 · see citing works
Prous, J., & Castañer, J. (1991) · Drugs of the Future · doi:10.1358/dof.1991.016.06.140759 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Coplen SE, Antman FM, Berlin JM, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for the maintenance of sinus rhythm after cardioversion. Circulation 1990;82:1108 -16.
- Bashir V, Wong C, Nathan AW, Cobbe SM, Campbell RW, Rasmussen HS. Efficacy and safety of dofetilide, a new class III antiarrhythmic agent in recurrent ventricular tachycardia [abstract]. Br Heart J 1992;68:116.
- Kayden H, Brodie BB, Steele JM. Procainamide; a review. Circulation 1957;15:118 -26.
- El-Sherif N, Zeiler RH, Crawlius W, Gough WB, Henkin R. QT prolonga- tion and polymorphic ventricular tachyarrhythmias due to bradycardia- dependent early afterdepolarization. J Am Coll Cardiol 1989;14:252-7.
- Hohnloser SH, Arendts W, Quart B. Incidence, type and dose-dependence of proarrhythmic events during sotalol therapy in patients treated for sustained VT/VF [abstract]. PACE 1992;15:551.
Cited by
Sorted by citations
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,225 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: executive summary
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01587-x · Cited by 1,358 · see citing works
Brugada, J., Katritsis, D. G., Arbelo, E., Arribas, F., Bax, J. J., Blomström‐Lundqvist, C., Calkins, H. G., Corrado, D., Deftereos, S. G., Diller, G., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz467 · Cited by 1,278 · see citing works
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,157 · see citing works
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Huezey, J.-Y. L., Lowe, J. E., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.013 · Cited by 921 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859 · see citing works
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · EP Europace · doi:10.1093/europace/eul097 · Cited by 663 · see citing works
Authors Task Force Members, Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl176 · Cited by 645 · see citing works
Morrison, L. J., Deakin, C. D., Morley, P. T., Callaway, C. W., Kerber, R. E., Kronick, S. L., Lavonas, E. J., Link, M. S., Neumar, R. W., Otto, C. W., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.971051 · Cited by 609 · see citing works
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · Circulation · doi:10.1161/circ.104.17.2118 · Cited by 607 · see citing works
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2983 · Cited by 489 · see citing works
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.018 · Cited by 465 · see citing works
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177031 · Cited by 341 · see citing works
Vernakalant Hydrochloride for Rapid Conversion of Atrial Fibrillation
Roy, D., Pratt, C. M., Torp-Pedersen, C. T., Wyse, D. G., Toft, E. S., Juul‐Möller, S., Nielsen, T., Rasmussen, S., Stiell, I. G., Coutu, B., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.723866 · Cited by 321 · see citing works
Atrial fibrillation: current knowledge and recommendations for management*1
Lévy, S. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1050 · Cited by 321 · see citing works
Franz, M. R., Karasik, P. L., Li, C., Moubarak, J., & Chavez, M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00385-9 · Cited by 301 · see citing works
McNamara, R. L., Tamariz, L. J., Segal, J. B., & Bass, E. B. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-12-200312160-00012 · Cited by 211 · see citing works
Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes
Darpö, B. (2001) · European Heart Journal Supplements · doi:10.1016/s1520-765x(01)90009-4 · Cited by 203 · see citing works
Deakin, C. D., Morrison, L. J., Morley, P. T., Callaway, C. W., Kerber, R. E., Kronick, S. L., Lavonas, E. J., Link, M. S., Neumar, R. W., Otto, C. W., et al. (2010) · Resuscitation · doi:10.1016/j.resuscitation.2010.08.027 · Cited by 201 · see citing works
Vos, M. A., Golitsyn, S. R., Stangl, K., Ruda, M. Y., Van Wijk, L., Harry, J. D., Perry, K. T., Touboul, P., Steinbeck, G., & Wellens, H. J. J. (1998) · Heart · doi:10.1136/hrt.79.6.568 · Cited by 200 · see citing works
Atrial fibrillation after cardiac operation: risks, mechanisms, and treatment
Hogue, C. W. J., & Hyder, M. (2000) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)01267-9 · Cited by 194 · see citing works
Katritsis, D. G., Boriani, G., Cosio, F. G., Hindricks, G., Jaïs, P., Josephson, M. E., Keegan, R., Kim, Y.-H., Knight, B. P., Kuck, K.-H., et al. (2017) · Europace · doi:10.1093/europace/euw301 · Cited by 188 · see citing works
Chevalier, P., Durand-Dubief, A., Burri, H., Cucherat, M., Kirkorian, G., & Touboul, P. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02705-5 · Cited by 184 · see citing works
“Early” Class III Drugs for the Treatment of Atrial Fibrillation
Blaauw, Y., Gögelein, H., Tieleman, R. G., van Hunnik, A., Schotten, U., & Allessie, M. A. (2004) · Circulation · doi:10.1161/01.cir.0000143050.22291.2e · Cited by 173 · see citing works
Bianconi, L. (2000) · European Heart Journal · doi:10.1053/euhj.1999.2039 · Cited by 126 · see citing works
Drolet, B., Zhang, S., Deschênes, D., Rail, J., NADEAU, S., Zhou, Z., January, C. T., & Turgeon, J. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00224.x · Cited by 116 · see citing works
Mounsey, J. P., & Dimarco, J. (2000) · Circulation · doi:10.1161/01.cir.102.21.2665 · Cited by 116 · see citing works
Nørgaard, B. L., Wachtell, K., Christensen, P. D., Madsen, B., Johansen, J. B., Christiansen, E. H., Graff, O. X., & Simonsen, E. H. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70363-7 · Cited by 111 · see citing works
Hornung, T., Bernard, E. J., JAEGGI, E. T., Howman-Giles, R. B., Celermajer, D. S., & Hawker, R. E. (1998) · Heart · doi:10.1136/hrt.80.4.322 · Cited by 107 · see citing works
Contrasting Efficacy of Dofetilide in Differing Experimental Models of Atrial Fibrillation
Li, D., Benardeau, A. M., & Nattel, S. (2000) · Circulation · doi:10.1161/01.cir.102.1.104 · Cited by 107 · see citing works
Merino, J. L., Tamargo, J. L., Blomström‐Lundqvist, C., Boriani, G., Crijns, H. J. G. M., Dobrev, D., Goette, A., Hohnloser, S. H., Naccarelli, G. V., Reiffel, J. A., et al. (2025) · EP Europace · doi:10.1093/europace/euaf076 · Cited by 105 · see citing works
Pharmacological Cardioversion of Atrial Fibrillation
Boriani, G., Diemberger, I., Biffi, M., Martignani, C., & Branzi, A. (2004) · Drugs · doi:10.2165/00003495-200464240-00003 · Cited by 91 · see citing works
Exaggerated QT prolongation after cardioversion of atrial fibrillation
Choy, A. M. J., Darbar, D., Dell’Orto, S., & Roden, D. M. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00226-0 · Cited by 89 · see citing works
Singh, B. N. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00674.x · Cited by 85 · see citing works
Hilleman, D. E., & Spinler, S. A. (2002) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.22.1.66.33492 · Cited by 84 · see citing works
Recent developments in atrial fibrillation
Iqbal, M. B., Taneja, A. K., Lip, G. Y. H., & Flather, M. D. (2005) · BMJ · doi:10.1136/bmj.330.7485.238 · Cited by 72 · see citing works
Knobloch, K., Brendel, J., Peukert, S., Rosenstein, B., Busch, A. E., & WIRTH, K. J. (2002) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-002-0599-x · Cited by 72 · see citing works
New Approaches to Atrial Fibrillation Management
Nattel, S., Khairy, P., Roy, D., Thibault, B., Guerra, P. G., Talajic, M. R., & Dubuc, M. (2002) · Drugs · doi:10.2165/00003495-200262160-00005 · Cited by 72 · see citing works
Guías de práctica clínica de la Sociedad Española de Cardiología en arritmias cardíacas
Garrote, J. A., Huerta, E. M., Moreno, O. M., Peinado, R., Álvarez, L. P., Granell, R. R., & Viñolas, X. (2001) · Revista Española de Cardiología · doi:10.1016/s0300-8932(01)76313-0 · Cited by 70 · see citing works
Abel, S., Nichols, D. J., Brearley, C. J., & Eve, M. D. (2000) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2000.00114.x · Cited by 68 · see citing works
Singh, B. N. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00147-7 · Cited by 66 · see citing works
Electrocardiographic differentiation of atrial flutter from atrial fibrillation by physicians
Knight, B. P., Michaud, G. F., Strickberger, S. A., & Morady, F. (1999) · Journal of Electrocardiology · doi:10.1016/s0022-0736(99)90002-x · Cited by 57 · see citing works
Clinical Experience with Dofetilide in the Treatment of Patients with Atrial Fibrillation
Prystowsky, E. N., Freeland, S., Branyas, N. A., Rardon, D. P., Fogel, R. I., Padanilam, B. J., & RIPPY, J. S. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.90402.x · Cited by 56 · see citing works
Rhythm Management in Atrial Fibrillation—with a Primary Emphasis on Pharmacological Therapy: Part 2
Costeas, C. A., Kassotis, J., Blitzer, M. L., & Reiffel, J. A. (1998) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1998.tb00132.x · Cited by 56 · see citing works
Dofetilide: a new class III antiarrhythmic agent
Roukoz, H., & Saliba, W. I. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.5.1.9 · Cited by 54 · see citing works
Management of the Older Person With Atrial Fibrillation
Aronow, W. S. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.6.m352 · Cited by 53 · see citing works
Antiarrhythmic agents and proarrhythmia
Chaudhry, G. M., & Haffajee, C. I. (2000) · Critical Care Medicine · doi:10.1097/00003246-200010001-00008 · Cited by 53 · see citing works
Dofetilide, a New Class III Antiarrhythmic Agent
Lenz, T. L., & Hilleman, D. E. (2000) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.20.9.776.35208 · Cited by 51 · see citing works
Boriani, G. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2679 · Cited by 50 · see citing works
Role of abnormal repolarization in the mechanism of cardiac arrhythmia
Osadchii, O. E. (2017) · Acta Physiologica · doi:10.1111/apha.12902 · Cited by 49 · see citing works
Electropharmacologic Effects of Class I and Class III Antiarrhythmia Drugs on Typical Atrial Flutter
Tai, C. T., Chen, S., Feng, A.-N., Yu, W., Chen, Y., & Chang, M.-S. (1998) · Circulation · doi:10.1161/01.cir.97.19.1935 · Cited by 49 · see citing works
Allen, M. J., Nichols, D. J., & Oliver, S. D. (2000) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2000.00243.x · Cited by 47 · see citing works
Shiyovich, A., Wolak, A., Yacobovich, L., Grosbard, A., & Katz, A. (2010) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181e73fcf · Cited by 47 · see citing works
Pharmacologic management of atrial fibrillation: Current therapeutic strategies
Lévy, S. (2001) · American Heart Journal · doi:10.1067/mhj.2001.109952 · Cited by 46 · see citing works
Lindeboom, J.-E., Kingma, J. H., Crijns, H. J. G. M., & Dunselman, P. H. J. M. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00927-3 · Cited by 46 · see citing works
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01586-8 · Cited by 46 · see citing works
Safety and efficacy of ibutilide in cardioversion of atrial flutter and fibrillation
Nair, M., George, L. K., & Koshy, S. K. G. (2011) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2011.01.080096 · Cited by 44 · see citing works
New advances in class III antiarrhythmic drug therapy
Sager, P. T. (1999) · Current Opinion in Cardiology · doi:10.1097/00001573-199901000-00004 · Cited by 43 · see citing works
McClellan, K. J., & Markham, A. (1999) · Drugs · doi:10.2165/00003495-199958060-00007 · Cited by 42 · see citing works
Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial
Holst, A. G., Tomcsányi, J., Vestbjerg, B., Grunnet, M., Sørensen, U. S., Diness, J. G., Bentzen, B. H., Edvardsson, N. G., Hohnloser, S. H., Bhatt, D. L., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02679-9 · Cited by 39 · see citing works
Kraft, M., Büscher, A., Wiedmann, F., L’hoste, Y., Haefeli, W. E., Frey, N., Katus, H. A., & Schmidt, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.638445 · Cited by 31 · see citing works
Kanki, H., Mitamura, H., Takatsuki, S., Sueyoshi, K., Shinagawa, K., Sato, T., & Ogawa, S. (1998) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1007758217189 · Cited by 32 · see citing works
A Multiple Ion Channel Blocker, NIP‐142, for the Treatment of Atrial Fibrillation
Tanaka, H., & Hashimoto, N. (2007) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2007.00025.x · Cited by 31 · see citing works
Tunblad, K., Lindbom, L., McFadyen, L., Jonsson, E. N., Marshall, S. F., & Karlsson, M. O. (2008) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-008-9099-z · Cited by 30 · see citing works
Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats
Doggrell, S. A., & Nand, V. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021778862 · Cited by 30 · see citing works
Dofetilide: A new pure class III antiarrhythmic agent
Falk, R. H., & DeCara, J. M. (2000) · American Heart Journal · doi:10.1067/mhj.2000.110457 · Cited by 30 · see citing works
Self-citationNew advances in class III antiarrhythmic drug therapy
Sager, P. T. (2000) · Current Opinion in Cardiology · doi:10.1097/00001573-200001000-00006 · Cited by 30 · see citing works
Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter
Banchs, J. E., Wolbrette, D. L., Samii, S. M., Penny-Peterson, E., Patel, P. P., Young, S. K., Gonzalez, M. D., & Naccarelli, G. V. (2008) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9290-6 · Cited by 28 · see citing works
WIRTH, K. J., & Knobloch, K. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000328 · Cited by 28 · see citing works
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castellà, M., Dan, G., Dilaveris, P., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 28 · see citing works
Special Problems With Antiarrhythmic Drug in the Elderly: Safety, Tolerability, and Efficacy
Dayer, M., & Hardman, S. M. C. (2002) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2002.0069.x · Cited by 27 · see citing works
Therapy of Atrial Fibrillation: Rhythm Control Versus Rate Control
CARLSSON, J., NEUZNER, J., & Rosenberg, Y. (2000) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2000.tb00861.x · Cited by 27 · see citing works
Antiarrhythmic agents for atrial fibrillation: focus on prolonging atrial repolarization
Singh, B. N., Mody, F. V., Lopez, B. M., & Sarma, J. S. M. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00718-3 · Cited by 27 · see citing works
Ranolazine: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias
Shenasa, M., Assadi, H. R., Heidary, S., & Shenasa, H. (2016) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2016.02.011 · Cited by 26 · see citing works
Derakhchan, K. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00320-5 · Cited by 25 · see citing works
Dofetilide: A Class III-Specific Antiarrhythmic Agent
Kalus, J. S., & Mauro, V. F. (2000) · Annals of Pharmacotherapy · doi:10.1345/aph.19185 · Cited by 25 · see citing works
Banchs, J. E., Baquero, G. A., Nickolaus, M. J., Wolbrette, D. L., Kelleman, J. J., Samii, S. M., Ting, J. G., Penny-Peterson, E., Davidson, W. R., Young, S. K., et al. (2013) · Congenital Heart Disease · doi:10.1111/chd.12129 · Cited by 24 · see citing works
Aronow, W. S. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01602.x · Cited by 23 · see citing works
Controlling Cardiac Arrhythmias: An Overview With a Historical Perspective
Singh, B. N. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00709-1 · Cited by 23 · see citing works
Dofetilide: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias
Shenasa, F., & Shenasa, M. (2016) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2016.02.006 · Cited by 20 · see citing works
Dofetilide Promotes Repolarization Abnormalities in Perfused Guinea-pig Heart
Osadchii, O. E. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6405-1 · Cited by 20 · see citing works
Informe del Grupo de Trabajo para la elaboración de guías de práctica clínica del American College of Cardiology y de la American Heart Association, del Comité de Guías de Práctica Clínica de la Sociedad Europea de Cardiología (comité de redacción para la revisión de la Guía de práctica clínica sobre el manejo de pacientes con fibrilación auricular, 2., & Desarrollado en colaboración con las asociaciones European Heart Rhythm Association y Heart Rhythm Society (2006) · Revista Española de Cardiología · doi:10.1157/13096583 · Cited by 20 · see citing works
Maykov, E. B., Yuricheva, Y. A., Mironov, N. Y., Sokolov, S. F., Sp, G., Розенштраух, Л. В., & Chazov, E. I. (2015) · Terapevticheskii arkhiv · doi:10.17116/terarkh201587138-48 · Cited by 19 · see citing works
Rouet, R., Picard, S., Libersa, C., Ghadanfar, M. M., Alabaster, C. T., & Gérard, J. (2000) · Circulation · doi:10.1161/01.cir.101.1.86 · Cited by 18 · see citing works
Morita, N., Tanaka, K., Yodogawa, K., Hayashi, M., Akutsu, K., Yamamoto, T., Satoh, N., Kobayashi, Y., Katoh, T., & Takano, T. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00846.x · Cited by 17 · see citing works
A Quarter of a Century Later: What is Dofetilide’s Clinical Role Today?
Wolbrette, D. L., HUSSAIN, S. K., Maraj, I., & Naccarelli, G. V. (2018) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248418784288 · Cited by 18 · see citing works
Choudhury, A., & Lip, G. Y. H. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.7.841 · Cited by 18 · see citing works
Vereckei, A., Gorski, J. C., Ujhelyi, M. R., Mehra, R., & Zipes, D. P. (2004) · Cardiovascular Drugs and Therapy · doi:10.1023/b:card.0000041246.13952.b4 · Cited by 17 · see citing works
Typical Atrial Flutter: A Practical Review
Johner, N., Namdar, M., & Shah, D. C. (2025) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.16542 · Cited by 16 · see citing works
Antiarrhythmic Drugs and Strategies
Opie, L. H., Dimarco, J., & Gersh, B. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-6158-8.50013-7 · Cited by 16 · see citing works
Kobayashi, Y., Atarashi, H., Ino, T., Kuruma, A., Nomura, A., Saitoh, H., & Hayakawa, H. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199709000-00015 · Cited by 16 · see citing works
Antiarrhythmic drugs and strategies
Nattel, S., Gersh, B. J., & Opie, L. H. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-3322-4.00017-x · Cited by 15 · see citing works
Aronow, W. S. (2002) · Heart Disease · doi:10.1097/00132580-200203000-00006 · Cited by 15 · see citing works
Dofetilide: a new drug to control cardiac arrhythmia
Elming, H., Brendorp, B., Pedersen, O. D., Køber, L., Elming, H., & Torp-Petersen, C. (2003) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.4.6.973 · Cited by 15 · see citing works
Hu, J., Yu, J., Chen, Q., Hu, J., Huang, Q., Xia, Z., Xia, Z., Ju, Z., Yuan, P., Fan, S. L., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012511 · Cited by 14 · see citing works
Prevention of and Medical Therapy for Atrial Arrhythmias in Heart Failure
Khand, A. U., Cleland, J. G. F., & DEEDWANIA, P. C. (2002) · Heart Failure Reviews · doi:10.1023/a:1020097728178 · Cited by 14 · see citing works
- Authors
- Falk, R. H., Pollak, A., Singh, S. N., & Friedrich, T.
- Affiliations
- Boston Medical Center (US)
- Corresponding author
- Falk, Rodney H.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 29
- Issue
- 2
- Pages
- 385-390
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2003632755
- Cited by
- 215
- References
- 30
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 4 · 2013: 4 · 2012: 5
- FWCI
- 15.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- dofetilide, intravenous administration, class III antiarrhythmic agents, sustained atrial fibrillation, atrial flutter, conversion to sinus rhythm, action potential prolongation
- MeSH terms
- Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Double-Blind Method, Hemodynamics, Humans, Phenethylamines, Sulfonamides, Treatment Outcome
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