The DOI matches its Crossref record; 22 of the 23 references it cites were found in a registry or an index.
Use of radial artery applanation tonometry and a generalized transfer function to determine aortic pressure augmentation in subjects with treated hypertension
Open accessAbstract
Objectives The purposes of this study were to investigate the use of radial artery applanation tonometry and a generalized transfer function for the assessment of central aortic pressure augmentation in subjects taking commonly used antihypertensive agents (angiotensin-converting enzyme inhibitors, beta-adrenergic blockers, Ca2+ antagonists, diuretic therapy).Background Applanation tonometry of the radial artery with a generalized transfer function has been proposed as a means of assessing central aortic blood pressure. Recently, a commercial apparatus based on this technique has become available; we therefore examined the effect of a generalized transfer function on derived central aortic pressure compared with measured brachial blood pressures and also investigated the potential of this technique to assess the influence of differing drug therapy.Methods Two hundred and sixty-two hypertensive patients on stable medication were studied using the PWV Medical Blood Pressure Analysis System (version 2, DAT-1).Results In univariate analysis, augmentation index showed association with age, sex, height and heart rate. In multivariate analysis, diastolic blood pressure and age (positively), height and heart rate (negatively) and sex were significantly associated. After adjustment for these variables, pressure augmentation was not associated with any antihypertensive treatment investigated. Linear relationships were demonstrated between brachial blood pressures and corresponding central pressures derived by transfer function methods.Conclusions Our findings suggest that if adjustment for central-peripheral pressure difference is necessary, simple linear relationships may be sufficient. Age, heart rate and height but not the class of antihypertensive medication affected the degree of pressure augmentation observed using this technique.
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“Because the augmentation index is influenced by changes in heart rate (HR), it was also accordingly corrected (26).”
From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [26]
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“Wave reflection indices may be influenced by changes in HR and by height and subendocardial viability index by changes in HR.”
From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [26]
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“The central augmentation index (AIx) is a measure of arterial stiffness derived by measuring the augmented pressure waveform in the ascending aorta divided by pulse pressure [9].”
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“Given the fact that brachial BP may explain 90 percent of central BP [19], low estimates of central BP are expected based on this faulty noninvasive brachial BP measurement.”
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“Radial artery applanation tonometry is a valid technique to easily assess pulse wave recording [27].”
MethodReconstruction of central aortic pressure based on TCN-attention model
Liu, W., Cao, Y., Fu, Y., Du, S., Wu, C., Tian, Y., Zhang, L., Liu, Y., Xu, L., & Gui, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1693431
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Metadata
- Authors
- Cameron, J. D., McGrath, B. P., & Dart, A. M.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Monash Medical Centre (AU)
- Corresponding author
- Cameron, James D.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 32
- Issue
- 5
- Pages
- 1214-1220
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2050727720
- Cited by
- 168
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- generalized transfer function, central blood pressure, augmentation index, treated hypertension, antihypertensive drugs, brachial blood pressure, pulse wave velocity
- MeSH terms
- Adrenergic beta-Antagonists, Adult, Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors, Aorta, Blood Pressure, Blood Pressure Determination, Calcium Channel Blockers, Cross-Sectional Studies, Diuretics, Female, Humans, Hypertension, Male, Middle Aged, Radial Artery
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