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Cited by 873Cardiovascular Health and Disease PreventionNon-Invasive Vital Sign MonitoringHemodynamic Monitoring and Therapy

An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man

KARAMANOGLU, M., O'ROURKE, M. F., AVOLIO, A. P., KELLY, R. P.·1993·European Heart Journal
DOI 10.1093/eurheartj/14.2.160
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Abstract

Amplification of the pressure pulse between central and peripheral arteries renders pressure values in the upper limb an inaccurate measure of ascending aortic (AA) pressure. Accuracy could be improved by allowance for such amplification. Transfer functions (TF) for pressures between AA and brachial artery (BA):(BATF) and between AA and radial artery (RA):(RATF) were derived from high-fidelity pressure recordings obtained at cardiac catheterization in 14 patients under control conditions, and after sublingual nitroglycerine 0.3 mg. There was no significant difference in BATF under control conditions and with nitroglycerine; hence results were pooled. Control and nitroglycerine results were also pooled to obtain a single RATF. BATF and RATF moduli peaked at 5 Hz and 4 Hz, reaching 2.5 and 2.8 times the value at zero frequency respectively. Frequency-dependent changes in modulus and phase of BATF and RATF were attributable to wave travel and reflection in the upper limb. BATF and RATF were compared to published transfer functions and those derived from analysis of aortic and brachial or radial pressure waves in previous publications. Results were similar. Our BATF and RATF were used to synthesize AA pressure waves from published peripheral pulses. Correspondence was close, especially for systolic pressure which differed by 2.4 +/- 1.0 (mean +/- SEM) mmHg, whereas recorded systolic pressure differed by 20.4 +/- 2.6 (mean +/- SEM) mmHg between central and peripheral sites. Results indicate that in adult humans a single generalized TF can be used with acceptable accuracy to determine central from peripheral pressure under different conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1093/eurheartj/14.2.160

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24 of 24 references verified0 citation errors · 0 not checkable

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  • When a validated integral transfer function is applied, the aortic pressure waveform can be derived from radial artery pressure waveform.

    “Radial artery pressure waveform is recorded noninvasively by applanation tonometry, 15 and when a validated integral transfer function is applied, 16 the aortic pressure waveform can be derived.”

    From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [16]

  • Augmentation index was measured using a validated, commercially available system (SphygmoCor).

    “The augmentation index was measured by using a validated, commercially available system (SphygmoCor; AtCor Medical, Sydney, Australia) that employs the principle of applanation tonometry and appropriate acquisition and analysis software for noninvasive recording and analysis of the arterial pulse.”

    From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [27]

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Authors
KARAMANOGLU, M., O'ROURKE, M. F., AVOLIO, A. P., & KELLY, R. P.
Affiliations
  • UNSW Sydney (AU)
  • St Vincent's Hospital Sydney (AU)
ORCID
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
1993-02-02
Volume
14
Issue
2
Pages
160-167
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/14.2.160
OpenAlex
W2067833505
Cited by
873
References
24
Citations by year
2026: 5 · 2025: 6 · 2024: 13 · 2023: 17 · 2022: 25 · 2021: 26 · 2020: 22 · 2019: 20 · 2018: 25 · 2017: 28 · 2016: 34 · 2015: 30 · 2014: 50 · 2013: 43 · 2012: 48
FWCI
5.61
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords
central blood pressure, peripheral arterial pressure, transfer function, brachial artery, radial artery, wave reflection, systolic blood pressure, arterial blood pressure measurement
MeSH terms
Adult, Aged, Aorta, Blood Pressure, Brachial Artery, Female, Humans, Male, Manometry, Middle Aged, Models, Biological, Radial Artery

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