Cited by 300Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

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Bi-directional immune–brain communication: Implications for understanding stress, pain, and cognition

Maier, Steven F·2003·Brain Behavior and Immunity

DOI 10.1016/s0889-1591(03)00032-1

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Abstract

The immune system and the central nervous system form a bi-directional communication network. The critical roles of pro-inflammatory cytokines in both the periphery and the nervous system are discussed. In the periphery, these cytokines initiate the processes that signal the brain that immune activation has occurred, and communicate this information over both neural and blood-borne routes. The arrival of these signals in the central nervous system induces a neural cascade that includes the de novo induction of pro-inflammatory cytokines. The functions of these cytokines in the nervous system are discussed, and it is argued that they play a key role in regulating the neural control of immune processes in the periphery. In addition, it is argued that these cytokines play a variety of other roles, and some implications of the cytokine network for understanding stress, behavior, sensory processing, mood, and cognition are described. The overall argument is that because brain-mediated host defense involves behavioral, sensory, mood, and cognitive alterations, immune activation, and immune products such as the cytokines can have a pervasive effect on these functions. Finally, these phenomena are placed in an evolutionary perspective.

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Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
The acute phase response
Baumann, H., & Gauldie, J. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90137-6 · Cited by 2,907
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
Fever: Role of Pyrogens and Cryogens
Kluger, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.93 · Cited by 1,220
Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130
Self-citation
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120
Glial activation: a driving force for pathological pain
Watkins, L. R., Milligan, E. D., & Maier, S. F. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01854-3 · Cited by 1,091
Self-citation
Cytokines and the nervous system II: actions and mechanisms of action
Rothwell, N. J., & Hopkins, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93890-a · Cited by 922

Show all 140 references

Research works printed but not linked: 10

Clathworthy, 1994, Cytokines may act as signals for the injury-induced hyperexcitability in nociceptive sensory neurons of Aplysia, Acta Biol. Hung., 43, 269
Gazda, 2000, Stress suppresses the adaptive immune response, Soc. Neurosci. Abstr., 26, 1958
Goehler, 1999, Interleukin-1 beta in immune cells of the abdominal vagus nerve: An immune to nervous system link?, J. Neurosci., 19, 2799, 10.1523/JNEUROSCI.19-07-02799.1999 · DOI
Gourine, 1998, Role of hypothalamic interleukin-1β in fever induced by cecal ligation and punture in rats, Am. J. Physiol., 275, R754
Hansen, 2001, The role of the vagus nerve in interleukin-1β-induced fever depends on dose, Am. J. Physiol., 280, R929
Laye, 1995, Subdiaphragmatic vagomotomy blocks induction of IL-1β mRNA in mice brain in response to peripheral LPS, Am. J. Physiol., 268, R1327
Laye, 2000, Endogenous brain IL-1 mediates LPS-induced anorezia and hypothalamic cytokine expression, Am. J. Physiol., 279, R93
Reeve, 1998, Electrophysiological study on the spinal effect of IL-1β on the responses of dorsal horn neurons, Soc. Neurosci. Abstr., 24, 155
Watkins, 1994, Blockade of interleukin-1 induced fever by subdiaphragmatic vagotomy: Evidence for vagal mediation of immune–brain communication, Neurosci. Lett., 183, 1
Watkins, 1994, Bockade of interleukin-1 induced fever by subdiaphragmatic vagotomy: Evidence for vagal mediation of immune-to-brain communication, Neurosci. Lett., 183, 1

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Alves, G. J., & Palermo‐Neto, J. (2007) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462006005000052 · Cited by 19
Untitled work
(2009) · PubMed · Cited by 19
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Authors: Maier, S. F.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Maier, Steven F
ORCID: Maier, Steven F
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2003-04
Volume: 17
Issue: 2
Pages: 69-85
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/s0889-1591(03)00032-1
OpenAlex: W2081694980
Cited by: 300
References: 140
Citations by year: 2026: 4 · 2025: 9 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 13 · 2017: 17 · 2016: 14 · 2015: 15 · 2014: 22 · 2013: 17 · 2012: 19
FWCI: 5.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: inflammatory cytokines, neuroinflammation, stress, pain, cognition, mood, sensory processing, evolutionary perspective
MeSH terms: Brain, Cognition, Humans, Pain, Stress, Physiological, Neuroimmunomodulation

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Bi-directional immune–brain communication: Implications for understanding stress, pain, and cognition

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