The Hematology of Inactivity
Abstract
Arthritis tends to promote inactivity, and inactivity tends to promote an unhealthful constellation of blood abnormalities that increases the risk of heart attack and stroke. The hematology of inactivity comprises the following: low plasma volume, high hematocrit, high plasma fibrinogen, elevated blood viscosity, increased platelet aggregability, and diminished fibrinolysis. Regular exercise reverses all these adverse blood changes and, thereby, helps prevent heart attack and stroke. Simply put, exercise "improves" the blood, making it flow more easily and clot less readily. This "healthy hematology of exercisers" is one more reason why prudent exercise is as vital for patients with arthritis as it is for the rest of us.
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Physical inactivity is associated with a prothrombotic hemostatic profile including low plasma volume, high hematocrit, high fibrinogen, elevated blood viscosity, increased platelet aggregation, and diminished fibrinolysis.
“In a 1990 review, physical inactivity had been associated with the following: low plasma volume, high hematocrit, high plasma fibrinogen, elevated blood viscosity, increased platelet aggregation, and diminished fibrinolysis (158).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [158]
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Physical Activity and the Incidence of Coronary Heart Disease
Powell, K. E., Thompson, P. D., Caspersen, C. J., & Kendrick, J. S. (1987) · Annual Review of Public Health · doi:10.1146/annurev.pu.08.050187.001345 · Cited by 1,457 · see citing works
Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler, C. A., Rutherford, J. D., Willich, S. N., Gleason, R. E., Williams, G. H., & Muller, J. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706113162405 · Cited by 1,072 · see citing works
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Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
- Authors
- Eichner, E. R.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Eichner, E. Randy
- Venue
- Rheumatic Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 1990-11
- Volume
- 16
- Issue
- 4
- Pages
- 815-825
- ISSN
- 0889-857X (ISSN-L)
- OpenAlex
- W190251932
- Cited by
- 10
- References
- 2
- Citations by year
- 2021: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rheumatic Disease Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- arthritis, physical inactivity, hematology, physical activity, plasma volume, hematocrit, fibrinogen, blood viscosity, platelet aggregation, fibrinolysis, cardiovascular risk, stroke, myocardial infarction
- MeSH terms
- Arthritis, Arthritis, Rheumatoid, Blood Platelets, Fibrinogen, Fibrinolysis, Hematocrit, Humans, Longevity, Myocardial Infarction, Physical Fitness, Exercise
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