Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Tofler, Geoffrey H.; Brezinski, Damian; Schafer, Andrew I.; Czeisler, Charles A.; Rutherford, John D.; Willich, Stefan N.; Gleason, Ray E.; Williams, Gordon H.; Muller, James E.

doi:10.1056/nejm198706113162405

Cited by 1,072Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsAntiplatelet Therapy and Cardiovascular Diseases

Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Tofler, Geoffrey H., Brezinski, Damian, Schafer, Andrew I., Czeisler, Charles A., Rutherford, John D., Willich, Stefan N., Gleason, Ray E., Williams, Gordon H. +1 more·1987·New England Journal of Medicine

DOI 10.1056/nejm198706113162405

Open this paper in CoChat — free account

Abstract

We have previously reported that the frequencies of myocardial infarction and of sudden cardiac death are highest during the period from 6 a.m. to noon. Since platelet aggregation may have a role in triggering these disorders, we measured platelet activity at 3-hour intervals for 24 hours in 15 healthy men. In vitro platelet responsiveness to either adenosine diphosphate (ADP) or epinephrine was lower at 6 a.m. (before the subjects arose) than at 9 a.m. (60 minutes after they arose). The lowest concentration of these agents required to produce biphasic platelet aggregation decreased (i.e., aggregability increased) from a mean +/- SEM of 4.7 +/- 0.6 to 3.7 +/- 0.6 microM (P less than 0.01) for ADP and from 3.7 +/- 0.8 to 1.8 +/- 0.5 microM (P less than 0.01) for epinephrine. The period from 6 to 9 a.m. was the only interval in the 24-hour period during which platelet aggregability increased significantly. We subsequently studied 10 subjects on alternate mornings after they arose at the normal time and after delayed arising. The morning increase in platelet aggregability was not observed when the subjects remained supine and inactive. Thus, there is a temporal association between increased platelet aggregability in the morning and an increased frequency of myocardial infarction and of sudden cardiac death. Demonstration of this association does not establish a cause--effect relation, but together with other evidence linking platelets to these disorders, it may provide insight into the mechanisms precipitating myocardial infarction and sudden cardiac death and aid in the design of more effective preventive measures.

Integrity signals

Registry

Crossref · 10.1056/nejm198706113162405

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Highest platelet aggregability and highest concentration of plasminogen activator inhibitor-1 (PAI-1) occur in the morning.
“For instance, highest platelet aggregability and highest concentration of plasminogen activator inhibitor-1 (PAI-1) occur in the morning (109, 110).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [109]

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal
Born, G. V. R. (1962) · Nature · doi:10.1038/194927b0 · Cited by 4,312 · see citing works
Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
Davies, M. J., & Thomas, A. C. (1985) · Heart · doi:10.1136/hrt.53.4.363 · Cited by 1,985 · see citing works
HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY
Meade, T. W., Brozović, M., Chakrabarti, R., Haines, A., Imeson, J., Mellows, S., Miller, G. J., North, W. R. S., Stirling, Y., & Thompson, S. G. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90111-x · Cited by 1,937 · see citing works
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine
Peuler, J. D., & Johnson, G. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90070-4 · Cited by 1,899 · see citing works
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884 · see citing works
Self-citation
Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina
Lewis, H. D., Davis, J. W., Archibald, D., Steinke, W. E., Smitherman, T. C., Doherty, J. E., Schnaper, H. W., LeWinter, M. M., Linares, E., Pouget, J. M., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308183090703 · Cited by 1,708 · see citing works
Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death
Davies, M. J., & Thomas, A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101801 · Cited by 1,694 · see citing works
Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645 · see citing works
Circadian variation of blood-pressure
Millar-Craig, M., Bishop, C., & Raftery, E. B. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92998-7 · Cited by 1,293 · see citing works
Platelet Activation in Unstable Coronary Disease
Fitzgerald, D. J., Roy, L., Catella, F., & FitzGerald, G. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151602 · Cited by 1,141 · see citing works
Circadian variation in the frequency of sudden cardiac death.
Muller, J. E., Ludmer, P. L., Willich, S. N., Tofler, G. H., Aylmer, G., Klangos, I., & Stone, P. H. (1987) · Circulation · doi:10.1161/01.cir.75.1.131 · Cited by 1,083 · see citing works
Self-citation
Coronary Angioscopy in Patients with Unstable Angina Pectoris
Sherman, C. T., Litvack, F., Grundfest, W. S., Lee, M., Hickey, A., Chaux, A., Kass, R. M., Blanche, C., Matloff, J. M., Morgenstern, L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610093151501 · Cited by 869 · see citing works
Obituary. Rupert Samuel Bruce Pearson.
Dm, O. (1974) · PubMed · Cited by 759 · see citing works
ATMOSPHERIC OZONE AND FEMORAL FRACTURES
Burton, J. L., Ensell, F. J., Leach, J. F., & Hall, K. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92450-2 · Cited by 587 · see citing works
Circadian variations of plasma catecholamine, cortisol and immunoreactive insulin concentrations in supine subjects
Turton, M. B., & Deegan, T. (1974) · Clinica Chimica Acta · doi:10.1016/0009-8981(74)90014-x · Cited by 322 · see citing works
Epidemiological characteristics of platelet aggregability.
Meade, T. W., Vickers, M. V., Thompson, S. G., Stirling, Y., Haines, A., & Miller, G. J. (1985) · BMJ · doi:10.1136/bmj.290.6466.428 · Cited by 295 · see citing works
Some Effects of Adrenaline and Anti-Adrenaline Compounds on Platelets in vitro and in vivo
O'Brien, J. R. (1963) · Nature · doi:10.1038/200763a0 · Cited by 293 · see citing works
Blood Fibrinolytic Activity in Man: Diurnal Variation and the Response to Varying Intensities of Exercise
ROSING, D. R., BRAKMAN, P., REDWOOD, D. R., GOLDSTEIN, R. E., BEISER, G. D., ASTRUP, T., & EPSTEIN, S. E. (1970) · Circulation Research · doi:10.1161/01.res.27.2.171 · Cited by 226 · see citing works
Blood rheology in arterial disease
Lowe, G. D. O. (1986) · Clinical Science · doi:10.1042/cs0710137 · Cited by 214 · see citing works
Platelet activation and secretion associated with emotional stress.
Levine, S. P., Towell, B. L., Suarez, A. M., Knieriem, L. K., Harris, M. M., & George, J. N. (1985) · Circulation · doi:10.1161/01.cir.71.6.1129 · Cited by 202 · see citing works
Smoking, Platelets and Thrombosis
Hawkins, R. I. (1972) · Nature · doi:10.1038/236450a0 · Cited by 193 · see citing works
Circadian changes in anticoagulant effect of heparin infused at a constant rate.
Decousus, H., Croze, M., Lévi, F., Jaubert, J., Perpoint, B., Bonadona, J. F. D., Reinberg, A., & Queneau, P. (1985) · BMJ · doi:10.1136/bmj.290.6465.341 · Cited by 181 · see citing works
Reversal of Abnormal Platelet Aggregability and Change in Exercise Tolerance in Patients with Angina Pectoris Following Oral Propranolol
Frishman, W. H., Weksler, B. B., Christodoulou, J. P., Smithen, C. S., & Killip, T. (1974) · Circulation · doi:10.1161/01.cir.50.5.887 · Cited by 180 · see citing works
Plasma Norepinephrine Levels Are Influenced by Sodium Intake, Glucocorticoid Administration, and Circadian Changes in Normal Man*
Stene, M. A., PANAGIOTIS, N. M., Tuck, M. L., Sowers, J. R., MAYES, D. M., & BERG, G. J. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-6-1340 · Cited by 141 · see citing works
XIV. Cerebral ischemia: the role of thrombosis and of antithrombotic therapy. Study group on antithrombotic therapy.
Genton, E., Barnett, H. J. M., Fields, W. S., Gent, M., & Hoak, J. C. (1977) · Stroke · doi:10.1161/01.str.8.1.150 · Cited by 140 · see citing works
The effect of physiological levels of fibrinogen on platelet aggregation
Meade, T. W., Vickers, M. V., Thompson, S. G., & Seghatchian, M. J. (1985) · Thrombosis Research · doi:10.1016/0049-3848(85)90185-9 · Cited by 104 · see citing works
Daily modifications of plasma fibrinogen platelets aggregation, Howell's time, PTT, TT, and antithrombin II in normal subjects and in patients with vascular disease.
Petralito, A., Mangiafico, R. A., Gibiino, S., Cuffari, M. A., Mf, M., & Ce, F. (1982) · PubMed · Cited by 93 · see citing works
Effect on human platelets of catecholamines at levels achieved in the circulation
Ardlie, N. G., McGuiness, J. A., & Garrett, J. J. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90070-x · Cited by 72 · see citing works
Variability in the Aggregation of Human Platelets by adrenaline
O'Brien, J. R. (1964) · Nature · doi:10.1038/2021188a0 · Cited by 67 · see citing works
The variability of human platelet aggregation
Harrison, M. J., Emmons, P. R., & Mitchell, J. R. A. (1967) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(67)80081-4 · Cited by 52 · see citing works
Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis
Kowey, P. R., Verrier, R. L., Lown, B., & Handin, R. I. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80103-9 · Cited by 30 · see citing works
Platelet catecholamines and platelet function in normal human subjects
Wilson, A. P. R., Smith, C., Prichard, B. N. C., & Betteridge, D. J. (1987) · Clinical Science · doi:10.1042/cs0730099 · Cited by 25 · see citing works
Potentiation by collagen or epinephrine of platelet responsiveness to aggregation. The possible role of substance(s) released from platelet membranes.
YOSHIDA, N., & Aoki, N. (1977) · PubMed · Cited by 16 · see citing works
Methods for Platelet Aggregation
Sixma, J. J. (1972) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3231-2_5 · Cited by 15 · see citing works
Effect of phentolamine on platelet aggregation in patients with pheochromocytoma
Zweifler, A. J., & Romero, S. (1975) · Thrombosis Research · doi:10.1016/0049-3848(75)90098-5 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
Epstein, F. H., Fuster, V., Badimón, L., Badimón, L., & Chesebro, J. H. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201303260506 · Cited by 3,804 · see citing works
Coronary Plaque Disruption
Falk, E., Shah, P. K., & Fuster, V. (1995) · Circulation · doi:10.1161/01.cir.92.3.657 · Cited by 3,536 · see citing works
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
Witwer, K. W., Buzás, E. I., Bemis, L., Bora, A., Lässer, C., Lötvall, J. O., Hoen, E. N. M. N., Piper, M. G., Sivaraman, S., Skog, J., et al. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20360 · Cited by 2,424 · see citing works
The Case-Crossover Design: A Method for Studying Transient Effects on the Risk of Acute Events
Maclure, M. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115853 · Cited by 2,327 · see citing works
Sympathetic-Nerve Activity during Sleep in Normal Subjects
Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280502 · Cited by 1,574 · see citing works
Perioperative Maintenance of Normothermia Reduces the Incidence of Morbid Cardiac Events
Frank, S. M. (1997) · JAMA · doi:10.1001/jama.1997.03540380041029 · Cited by 1,261 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Epidural Anesthesia and Analgesia
Liu, S., Carpenter, R. L., & Neal, J. M. (1995) · Anesthesiology · doi:10.1097/00000542-199506000-00019 · Cited by 1,099 · see citing works
Association between dental health and acute myocardial infarction.
Mattila, K. J., Nieminen, M. S., Valtonen, V., Rasi, V., Kesäniemi, Y. A., Syrjala, S. L., Jungell, P., Isoluoma, M., Hietaniemi, K. L., & Jokinen, M. J. (1989) · BMJ · doi:10.1136/bmj.298.6676.779 · Cited by 1,057 · see citing works
Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.
Fuster, V (1994) · Circulation · doi:10.1161/01.cir.90.4.2126 · Cited by 848 · see citing works
Sudden Cardiac Death Triggered by an Earthquake
Leor, J., Poole, W. K., & Kloner, R. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602153340701 · Cited by 819 · see citing works
Circadian variation in the incidence of sudden cardiac death in the framingham heart study population
Willich, S. N., Levy, D., Rocco, M. B., Tofler, G. H., Stone, P. H., & Muller, J. E. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91027-7 · Cited by 653 · see citing works
Self-citation
Sleep Apnea and Cardiovascular Disease
Leung, R. S. T., & Bradley, T. D. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.12.2107045 · Cited by 645 · see citing works
Platelet Hyperreactivity and Prognosis in Survivors of Myocardial Infarction
Trip, M. D., Cats, V. M., van Capelle, F. J. L., & Vreeken, J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222201 · Cited by 614 · see citing works
Circadian Variation in Vascular Tone and Its Relation to α-Sympathetic Vasoconstrictor Activity
Panza, J. A., Epstein, S. E., & Quyyumi, A. A. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110033251402 · Cited by 607 · see citing works
Morning increase in onset of ischemic stroke.
Marler, J. R., Price, T. R., Clark, G., Muller, J. E., Robertson, T., Mohr, J. P., Hier, D. B., Wolf, P. A., Caplan, L. R., & Foulkes, M. A. (1989) · Stroke · doi:10.1161/01.str.20.4.473 · Cited by 515 · see citing works
Self-citation
Physical Exertion as a Trigger of Acute Myocardial Infarction
Willich, S. N., Lewis, M., Lowel, H., Arntz, H.-R., Schubert, F., & Schroder, R. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312023292302 · Cited by 682 · see citing works
Self-citation
Seasonal Distribution of Acute Myocardial Infarction in the Second National Registry of Myocardial Infarction 11The National Registry of Myocardial Infarction is supported by Genentech, Inc., South San Francisco, California. Genentech, Inc. reimburses ClinTrials Research, Inc. for the cost of data analysis and biostatistical services.
Spencer, F. A., Goldberg, R. J., Becker, R. C., & Gore, J. M. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00098-9 · Cited by 481 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1).
Angleton, P., Chandler, W. L., & Schmer, G. (1989) · Circulation · doi:10.1161/01.cir.79.1.101 · Cited by 393 · see citing works
Platelet Activation With Unfractionated Heparin at Therapeutic Concentrations and Comparisons With a Low-Molecular-Weight Heparin and With a Direct Thrombin Inhibitor
Xiao, Z., & Théroux, P. (1998) · Circulation · doi:10.1161/01.cir.97.3.251 · Cited by 381 · see citing works
Increased morning incidence of myocardial infarction in the ISAM Study: absence with prior beta-adrenergic blockade. ISAM Study Group.
Willich, S. N., Linderer, T., Wegscheider, K., Leizorovicz, A., Alamercery, I., & Schröder, R. (1989) · Circulation · doi:10.1161/01.cir.80.4.853 · Cited by 374 · see citing works
Self-citation
Drug delivery systems for programmed and on-demand release
Davoodi, P., Lee, L. Y., Xu, Q., Sunil, V., Sun, Y., Soh, S., & Wang, C. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.002 · Cited by 359 · see citing works
Effects of sleep deprivation on neural circulatory control
Kato, M., Phillips, B. G., Sigurdsson, G., Narkiewicz, K., Pesek, C. A., & Somers, V. K. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1173 · Cited by 348 · see citing works
The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome
Matsuo, K. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1332 · Cited by 331 · see citing works
Impact of Circadian Disruption on Cardiovascular Function and Disease
Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 333 · see citing works
HYPERTENSION, CARDIAC ARRHYTHMIAS, MYOCARDIAL INFARCTION, AND STROKE IN RELATION TO OBSTRUCTIVE SLEEP APNEA
Shepard, J. (1992) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00873-x · Cited by 329 · see citing works
Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity
Nagalla, S., Shaw, C. A., Kong, X., Kondkar, A. A., Edelstein, L. C., Ma, L., Chen, J., McKnight, G. S., López, J. A., Yang, L., et al. (2011) · Blood · doi:10.1182/blood-2010-09-299719 · Cited by 327 · see citing works
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 327 · see citing works
CIRCADIAN VARIATION OF TOTAL ISCHAEMIC BURDEN AND ITS ALTERATION WITH ANTI-ANGINAL AGENTS
Mulcahy, D., Cunningham, D., Crean, P., Wright, C., Keegan, J., Quyyumi, A. A., Park, A., & Fox, K. M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92414-2 · Cited by 315 · see citing works
Effect of strenuous exercise on platelet activation state and reactivity.
Kestin, A. S., Ellis, P. A., Barnard, M. R., Errichetti, A., ROSNER, B. A., & Michelson, A. D. (1993) · Circulation · doi:10.1161/01.cir.88.4.1502 · Cited by 310 · see citing works
Circadian rhythms and cardiovascular health
Portaluppi, F., Tiseo, R., Smolensky, M. H., Hermida, R. C., Ayala, D. E., & Fabbian, F. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.04.003 · Cited by 310 · see citing works
Obstructive Sleep Apnea and Cardiovascular Disease: Role of the Metabolic Syndrome and Its Components
Jean‐Louis, G., Zizi, F., Clark, L. T., Brown, C. D., & McFarlane, S. I. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27191 · Cited by 303 · see citing works
Endothelial dysfunction: Clinical implications
Drexler, H. (1997) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(97)80030-8 · Cited by 291 · see citing works
Circadian variation of acute myocardial infarction and the effect of low-dose aspirin in a randomized trial of physicians.
Ridker, P. M., Manson, J. E., Buring, J. E., Muller, J. E., & Hennekens, C. H. (1990) · Circulation · doi:10.1161/01.cir.82.3.897 · Cited by 285 · see citing works
Self-citation
Spontaneous Platelet Activation and Aggregation During Obstructive Sleep Apnea and Its Response to Therapy With Nasal Continuous Positive Airway Pressure
Bokinsky, G. E., Miller, M. J., Ault, K. A., Husband, P., & Mitchell, J. (1995) · CHEST Journal · doi:10.1378/chest.108.3.625 · Cited by 284 · see citing works
Depression in patients with cardiac disease
Lespérance, F., & Frasure‐Smith, N. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00102-6 · Cited by 283 · see citing works
Morning increase in platelet aggregability. Association with assumption of the upright posture.
Brezinski, D. A., Tofler, G. H., Muller, J. E., Pohjola‐Sintonen, S., Willich, S. N., Schafer, A. I., Czeisler, C. A., & Williams, G. H. (1988) · Circulation · doi:10.1161/01.cir.78.1.35 · Cited by 282 · see citing works
Self-citation
Chronobiological Patterns of Acute Aortic Dissection
Mehta, R. H., Manfredini, R., Hassan, F., Sechtem, U. P., Bossone, E., Oh, J. K., Cooper, J. V., Smith, D. E., Portaluppi, F., Penn, M. S., et al. (2002) · Circulation · doi:10.1161/01.cir.0000027568.39540.4b · Cited by 280 · see citing works
The role of plaque rupture and thrombosis in coronary artery disease
Zaman, A., Helft, G., Worthley, S. G., & Badimón, J. J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00479-7 · Cited by 279 · see citing works
Early Morning Attenuation of Endothelial Function in Healthy Humans
Otto, M. E., Svatikova, A., Barretto, R. B. D. M., Santos, S., Hoffmann, M., Khandheria, B., & Somers, V. (2004) · Circulation · doi:10.1161/01.cir.0000128207.26863.c4 · Cited by 273 · see citing works
Leukocyte activation with platelet adhesion after coronary angioplasty: A mechanism for recurrent disease?
Mickelson, J. K., Lakkis, N. M., Villarreal-Levy, G., Hughes, B. J., & Smith, C. W. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00164-7 · Cited by 268 · see citing works
Increased Platelet Aggregability Associated With Platelet GPIIIa Pl A2 Polymorphism
Feng, D., Lindpaintner, K., Larson, M. G., Rao, V. S., O’Donnell, C. J., Lipinska, I., Schmitz, C., Sutherland, P. A., Silbershatz, H., D’Agostino, R. B., et al. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.1142 · Cited by 260 · see citing works
Self-citation
Plasma Epinephrine and Norepinephrine Concentrations of Healthy Humans Associated With Nighttime Sleep and Morning Arousal
Dodt, C., Breckling, U., Derad, I., Fehm, H. L., & Jan Born, A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.71 · Cited by 252 · see citing works
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 249 · see citing works
Sudden cardiac death. Support for a role of triggering in causation.
Willich, S. N., Maclure, M., Mittleman, M. A., Arntz, H. R., & Muller, J. E. (1993) · Circulation · doi:10.1161/01.cir.87.5.1442 · Cited by 246 · see citing works
Self-citation
The iron paradigm of ischemic heart disease
Sullivan, J. L. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90887-9 · Cited by 241 · see citing works
Effect of moderate dose of alcohol with evening meal on fibrinolytic factors
Hendriks, H., Veenstra, J., Wierik, E. J. M. V.-T., Schaafsma, G., & Kluft, C. (1994) · BMJ · doi:10.1136/bmj.308.6935.1003 · Cited by 241 · see citing works
Prognostic Value of the Variability in Home-Measured Blood Pressure and Heart Rate: The Finn-Home Study
Johansson, J. K., Niiranen, T. J., Puukka, P. J., & Jula, A. M. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.178657 · Cited by 240 · see citing works
Autonomic Modulation of the Cardiovascular System during Sleep
Mancia, G. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280511 · Cited by 240 · see citing works
Total Sleep Deprivation Elevates Blood Pressure Through Arterial Baroreflex Resetting: a Study with Microneurographic Technique
Ogawa, Y., Kanbayashi, T., Saito, Y., Takahashi, Y., Kitajima, T., Takahashi, K., Hishikawa, Y., & Shimizu, T. (2003) · SLEEP · doi:10.1093/sleep/26.8.986 · Cited by 235 · see citing works
Effects of circadian disruption on the cardiometabolic system
Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232 · see citing works
Genetic and Environmental Contributions to Platelet Aggregation
O’Donnell, C. J., Larson, M. G., Feng, D., Sutherland, P. A., Lindpaintner, K., Myers, R. H., D’Agostino, R. B., Levy, D. A., & Tofler, G. H. (2001) · Circulation · doi:10.1161/01.cir.103.25.3051 · Cited by 224 · see citing works
Self-citation
Circadian variation of blood pressure: The basis for the chronotherapy of hypertension
Hermida, R. C., Ayala, D. E., & Portaluppi, F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.08.003 · Cited by 221 · see citing works
Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery?
Youan, B.-B. C. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.05.015 · Cited by 217 · see citing works
Circadian variations of infarct size in acute myocardial infarction
Suárez-Barrientos, A., López‐Romero, P., Vivas, D., Castro-Ferreira, F., Nuñez-Gil, I. J., Franco, E., Ruiz-Mateos, B., García-Rubira, J. C., Fernández‐Ortíz, A., Macaya, C., et al. (2011) · Heart · doi:10.1136/hrt.2010.212621 · Cited by 212 · see citing works
Different effects of strenuous exercise and moderate exercise on platelet function in men.
Wang, J., Jen, J., Kung, H.-W., Lin, L.-J., Hsiue, T., & Chen, H. (1994) · Circulation · doi:10.1161/01.cir.90.6.2877 · Cited by 213 · see citing works
Clinical Value of Ambulatory Blood Pressure: Evidence and Limits
Mancia, G., & Verdecchia, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.303755 · Cited by 211 · see citing works
Spiral computed tomographic scanning and magnetic resonance angiography for the diagnosis of pulmonary embolism
Greniér, P., & Beigelman‐Aubry, C. (1998) · Thorax · doi:10.1136/thx.53.2008.s25 · Cited by 212 · see citing works
Circadian variation in cardiovascular events
Muller, J. E. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00278-7 · Cited by 210 · see citing works
Self-citation
Pathophysiology of silent myocardial ischemia during daily life. Hemodynamic evaluation by simultaneous electrocardiographic and blood pressure monitoring.
DEEDWANIA, P. C., & Nelson, J. R. (1990) · Circulation · doi:10.1161/01.cir.82.4.1296 · Cited by 209 · see citing works
Effects of beta blockers (atenolol or metoprolol) on heart rate variability after acute myocardial infarction
Sandrone, G., Mortara, A., Torzillo, D., Rovere, M. T. L., Malliani, A., & Lombardi, F. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90400-6 · Cited by 198 · see citing works
The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
Scheer, F. A. J. L., Michelson, A. D., Frelinger, A. L., Evoniuk, H., Kelly, E. E., McCarthy, M., Doamekpor, L. A., Barnard, M. R., & Shea, S. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024549 · Cited by 206 · see citing works
Association of Episodic Physical and Sexual Activity With Triggering of Acute Cardiac Events: Systematic Review and Meta-analysis
Dahabreh, I. J. (2011) · JAMA · doi:10.1001/jama.2011.336 · Cited by 199 · see citing works
Influence of Treatment on Muscle Sympathetic Nerve Activity in Sleep Apnea
Waradekar, N. V., Sinoway, L. I., Zwillich, C. W., & Leuenberger, U. A. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.4.8616563 · Cited by 199 · see citing works
Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization
Martino, T. A., Tata, N., Belsham, D. D., Chalmers, J., Straume, M., Lee, P., Pribiag, H., Khaper, N., Liu, P. P., Dawood, F., et al. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.083568 · Cited by 196 · see citing works
The possible role of hemorheology in atherothrombogenesis
Köenig, W., & Ernst, E. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90234-8 · Cited by 196 · see citing works
Nicotine effects on eicosanoid formation and hemostatic function: Comparison of transdermal nicotine and cigarette smoking
Benowitz, N. L., FitzGerald, G. A., Wilson, M., & Zhang, Q. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90431-y · Cited by 195 · see citing works
Morning Hypertension: The Strongest Independent Risk Factor for Stroke in Elderly Hypertensive Patients
Kario, K., Ishikawa, J., Pickering, T. G., Hoshide, S., EGUCHI, K., Morinari, M., Hoshide, Y., Kuroda, T., & Shimada, K. (2006) · Hypertension Research · doi:10.1291/hypres.29.581 · Cited by 194 · see citing works
Biology and medicine of soccer: An update
Shephard, R. J. (1999) · Journal of Sports Sciences · doi:10.1080/026404199365498 · Cited by 194 · see citing works
Biobehavioral factors in sudden cardiac death.
Kamarck, T. W., & Jennings, J. R. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.109.1.42 · Cited by 191 · see citing works
Circadian rhythm of heart rate variability after acute myocardial infarction and its influence on the prognostic value of heart rate variability
Malík, M., Farrell, T. G., & Camm, A. J. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90503-s · Cited by 190 · see citing works
Sudden Death in Coronary Artery Disease
Mehta, D., Curwin, J. H., Gomes, J. A., & Fuster, V. (1997) · Circulation · doi:10.1161/01.cir.96.9.3215 · Cited by 188 · see citing works
Vulnerable Plaque: Pathobiology and Clinical Implications
Kullo, I., Edwards, W. D., & Schwartz, R. S. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-12-199812150-00010 · Cited by 188 · see citing works
Task Force II: Blood pressure measurement and cardiovacular outcome
Staessen, J. A., Asmar, R. G., Buyzere, M. D., Imai, Y., Parati, G., Shimada, K., Stergiou, G. S., Redón, J., & Verdecchia, P. (2001) · Blood Pressure Monitoring · doi:10.1097/00126097-200112000-00016 · Cited by 187 · see citing works
Increased Platelet Intracellular Calcium Concentration in Patients With Bipolar Affective Disorders
Dubovsky, S. L. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810070058010 · Cited by 186 · see citing works
Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin.
Larsson, P. T., Wallén, N. H., & Hjemdahl, P. (1994) · Circulation · doi:10.1161/01.cir.89.5.1951 · Cited by 186 · see citing works
Time of onset of symptoms of acute myocardial infarction
Goldberg, R. J., Brady, P. M., Muller, J. E., Chen, Z., de Groot, M., Zonneveld, P., & Dalen, J. E. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90577-n · Cited by 183 · see citing works
Self-citation
Sleep apnea and mortality in an aged cohort.
Bliwise, D. L., Bliwise, N. G., Partinen, M., Pursley, A. M., & Dement, W. C. (1988) · American Journal of Public Health · doi:10.2105/ajph.78.5.544 · Cited by 181 · see citing works
Platelet function in patients with obstructivesleep apnoea syndrome
Sanner, B. M., KONERMANN, M., Tepel, M., Groetz, J., Mummenhoff, C., & Zidek, W. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.16d14.x · Cited by 180 · see citing works
Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease Study.
Elwood, P. C., Renaud, S., Sharp, D. S., Beswick, A. D., O'Brien, J. R., & Yarnell, J. W. G. (1991) · Circulation · doi:10.1161/01.cir.83.1.38 · Cited by 179 · see citing works
Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans
Heesch, C. M., Wilhelm, C. R., Ristich, J., Adnane, J., Bontempo, F. A., & Wagner, W. R. (2000) · Heart · doi:10.1136/heart.83.6.688 · Cited by 175 · see citing works
Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle
Scheer, F. A. J. L., & Shea, S. A. (2014) · Blood · doi:10.1182/blood-2013-07-517060 · Cited by 172 · see citing works
Toward the quiescent coronary plaque.
Macisaac, A., Thomas, J., & Topol, E. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90442-4 · Cited by 184 · see citing works
Relationship between hemostatic abnormalities and neuroendocrine activity in heart failure
Sbarouni, E., Bradshaw, A. E., Andreotti, F., Tuddenham, E. G. D., Oakley, C. M., & Cleland, J. G. F. (1994) · American Heart Journal · doi:10.1016/0002-8703(94)90670-x · Cited by 169 · see citing works
Outcome of primary angioplasty for acute myocardial infarction during routine duty hours versus during off-hours
Henriques, J. P. S., Haasdijk, A., & Zijlstra, F. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00461-3 · Cited by 168 · see citing works
Circadian variation in the frequency of ischemic stroke.
Argentino, C., Toni, D., Rasura, M., Violi, F., Sacchetti, M. L., Allegretta, A., BALSANO, F., & Fieschi, C. (1990) · Stroke · doi:10.1161/01.str.21.3.387 · Cited by 167 · see citing works
Blood pressure surge on rising
Gosse, P., Lasserre, R., Minifi??, C., Lemetayer, P., & Clémenty, J. (2004) · Journal of Hypertension · doi:10.1097/00004872-200406000-00011 · Cited by 165 · see citing works
Water, Other Fluids, and Fatal Coronary Heart Disease
Chan, J., Knutsen, S. F., Blix, G. G., Lee, J. W., & Fraser, G. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.9.827 · Cited by 165 · see citing works
Effects of Exercise on Blood Coagulation, Fibrinolysis and Platelet Aggregation
Elsayed, M. (1996) · Sports Medicine · doi:10.2165/00007256-199622050-00002 · Cited by 163 · see citing works
Diurnal variation in incidence of stroke: Oxfordshire community stroke project.
Wroe, S. J., Sandercock, P. A., Bamford, J., Dennis, M. S., Slattery, J., & Warlow, C. (1992) · BMJ · doi:10.1136/bmj.304.6820.155 · Cited by 162 · see citing works
Measuring plasma fibrinogen to predict stroke and myocardial infarction.
Minno, G. D., & Mancini, M. (1990) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.10.1.1 · Cited by 162 · see citing works
Natural and Unnatural Triggers of Myocardial Infarction
Kloner, R. A. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.07.001 · Cited by 160 · see citing works
The time‐of‐day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment
Schloss, M. J., Horckmans, M., Nitz, K., Duchêne, J., Drechsler, M. D., Bidzhekov, K., Scheiermann, C., Weber, C., Soehnlein, O., & Steffens, S. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201506083 · Cited by 160 · see citing works
Circadian Variation in Onset of Acute Ischemic Stroke
Marsh, E. E., Biller, J., Adams, H. P., Marler, J. R., Hulbert, J. R., Love, B. B., & Gordon, D. L. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110032012 · Cited by 160 · see citing works
Sleep-Related Breathing Disorders and Risk of Stroke
Mohsenin, V. (2001) · Stroke · doi:10.1161/01.str.32.6.1271 · Cited by 163 · see citing works
Blood hemostasis in exercise and training
El-Sayed, Sale, C., Jones, P., & CHESTER, M. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200005000-00007 · Cited by 160 · see citing works
Recent advances in circadian rhythms in cardiovascular system
Chen, L., & Yang, G. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00071 · Cited by 157 · see citing works
Obstructive sleep apnoea and stroke
Yaggi, H. K., & Mohsenin, V. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00766-5 · Cited by 157 · see citing works
Antiplatelet therapy
Schafer, A. I. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)80077-5 · Cited by 156 · see citing works
Self-citation

Morning increase in platelet aggregability. Association with assumption of the upright posture.
ABrezinski, D., HTofler, G., EMuller, J., SPohjola-Sintonen, NWillich, S., ISchafer, A., ACzeisler, C., & HWilliams, G. (1988) · Circulation
Daily variations in platelet aggregation and adhesion in healthy subjects
Fujimura, A., Ohashi, K., & Ebihara, A. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90099-b · Cited by 32 · see citing works
Circadian Variation of Cardiovascular Disease and Sympathetic Activity
Muller, J. E., Tofler, G. H., Willich, S. N., & Stone, P. H. (1987) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198710011-00020 · Cited by 20 · see citing works
Self-citation
Platelet alpha2 adrenoceptor characteristics during the morning increase in platelet aggregability
Willich, S. N., Tofler, G. H., Brezinski, D. A., Schafer, A. I., Muller, J. E., Michel, T. M., & Colucci, W. S. (1992) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060212 · Cited by 21 · see citing works
Self-citation
Concurent morning increase in platelet aggregability and risk of myocardial infarction and sudden cardiac death
Kaye, B. L., & Tofler, G. H. (1988) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198808000-00105 · Cited by 2 · see citing works
Self-citation

Authors: Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler, C. A., Rutherford, J. D., Willich, S. N., Gleason, R. E., Williams, G. H., & Muller, J. E.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Tofler, Geoffrey H.
Schafer, Andrew I.
Czeisler, Charles A.
Williams, Gordon H.
Muller, James E.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1987-06-11
Volume: 316
Issue: 24
Pages: 1514-1518
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198706113162405
OpenAlex: W1974742589
Cited by: 1,072
References: 35
Citations by year: 2026: 7 · 2025: 14 · 2024: 8 · 2023: 13 · 2022: 22 · 2021: 18 · 2020: 11 · 2019: 18 · 2018: 16 · 2017: 22 · 2016: 18 · 2015: 21 · 2014: 28 · 2013: 27 · 2012: 29
FWCI: 21.71
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (9535 A607606)
National Heart, Lung, and Blood Institute (HL-27465, HL-705861)
Topics: Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Keywords: platelet aggregability, circadian rhythm, myocardial infarction, sudden cardiac death, adenosine diphosphate, epinephrine, supine rest, platelet function
MeSH terms: Adenosine Diphosphate, Adult, Death, Sudden, Epinephrine, Hematocrit, Humans, Male, Myocardial Infarction, Platelet Aggregation, Platelet Count, Posture, Time, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks