Cited by 201Antibiotics Pharmacokinetics and EfficacyAntibiotic Use and ResistanceAntibiotic Resistance in Bacteria

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Intracellular pharmacodynamics of antibiotics

Carryn, Stéphane, Chanteux, Hugues, Seral, Cristina, Mingeot-Leclercq, Marie-Paule, Van Bambeke, Françoise, Tulkens, Paul M·2003·Infectious Disease Clinics of North America

DOI 10.1016/s0891-5520(03)00066-7

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Abstract

This article establishes the pharmacokinetic-pharmacodynamic parameters that are important when considering the intracellular activity of antibiotics. Generally speaking, the main classes of antibiotics seem to share globally the same properties against extracellular and intracellular organisms. The specific cellular pharmacokinetic properties may modulate those parameters so as to let other ones to become critical. Simple rules, such as equating accumulation and activity, are certainly incorrect, and other determinants need to be added to the equation. Finally, this article emphasizes the fact that much remains to be done in this area before rational therapeutic choices can be made.

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Authors: Carryn, S., Chanteux, H., Seral, C., Mingeot-Leclercq, M.-P., Van Bambeke, F., & Tulkens, P. M.
Affiliations: UCLouvain (BE)
Corresponding author: Tulkens, Paul M
ORCID: Chanteux, Hugues
Seral, Cristina
Tulkens, Paul M
Venue: Infectious Disease Clinics of North America
Publisher: Elsevier BV
Published: 2003-09
Volume: 17
Issue: 3
Pages: 615-634
ISSN: 0891-5520 (ISSN-L)
DOI: 10.1016/s0891-5520(03)00066-7
OpenAlex: W2064809559
Cited by: 201
References: 116
Citations by year: 2026: 5 · 2025: 11 · 2024: 13 · 2023: 8 · 2022: 10 · 2021: 16 · 2020: 9 · 2019: 7 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 15 · 2014: 15 · 2013: 9 · 2012: 5
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Infectious Disease Clinics of North America (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: antibiotics, intracellular accumulation, antibiotic activity, cellular pharmacokinetics, rational antibiotic therapy
MeSH terms: Anti-Bacterial Agents, Bacteria, Bacterial Infections, Humans, Intracellular Space

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