The DOI matches its Crossref record; 115 of the 116 references it cites were found in a registry or an index.
Intracellular pharmacodynamics of antibiotics
Abstract
This article establishes the pharmacokinetic-pharmacodynamic parameters that are important when considering the intracellular activity of antibiotics. Generally speaking, the main classes of antibiotics seem to share globally the same properties against extracellular and intracellular organisms. The specific cellular pharmacokinetic properties may modulate those parameters so as to let other ones to become critical. Simple rules, such as equating accumulation and activity, are certainly incorrect, and other determinants need to be added to the equation. Finally, this article emphasizes the fact that much remains to be done in this area before rational therapeutic choices can be made.
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“Poor drug diffusion across the host cell membrane and its active efflux via drug transporters can reduce activity against intracellular pathogens 63 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [63]
Citations
Cites
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Self-citationRole of nitric oxide synthesis in macrophage antimicrobial activity
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Mammalian defensins in immunity: more than just microbicidal
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The cell biology of Listeria monocytogenes infection
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Items 201–201 of 201
Li, S., Hao, W., Ye, Z., Mo, G., Shi, C., Kong, X., Zhang, J., Jiao, X., Wang, A., & Wang, Y. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03688
Metadata
- Authors
- Carryn, S., Chanteux, H., Seral, C., Mingeot-Leclercq, M.-P., Van Bambeke, F., & Tulkens, P. M.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Tulkens, Paul M
- Venue
- Infectious Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 17
- Issue
- 3
- Pages
- 615-634
- ISSN
- 0891-5520 (ISSN-L)
- OpenAlex
- W2064809559
- Cited by
- 201
- References
- 116
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 8 · 2022: 10 · 2021: 16 · 2020: 9 · 2019: 7 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 15 · 2014: 15 · 2013: 9 · 2012: 5
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Infectious Disease Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- antibiotics, intracellular accumulation, antibiotic activity, cellular pharmacokinetics, rational antibiotic therapy
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Bacterial Infections, Humans, Intracellular Space
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