Mammalian defensins in immunity: more than just microbicidal

Dendritic cells and the control of immunity

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Chemokines

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Chemokines and leukocyte traffic

Baggiolini, M. (1998) · Nature · doi:10.1038/33340 · Cited by 2,685 · see citing works

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809 · see citing works

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,309 · see citing works

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

Yang, D., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J., Wooters, J., Oppenheim, J. J., & Chertov, O. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1069 · Cited by 1,238 · see citing works

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

Malaviya, R., Ikeda, T., Ross, E., & Abraham, S. N. (1996) · Nature · doi:10.1038/381077a0 · Cited by 1,123 · see citing works

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076 · see citing works

Critical protective role of mast cells in a model of acute septic peritonitis

Echtenacher, B., Männel, D. N., & Hültner, L. (1996) · Nature · doi:10.1038/381075a0 · Cited by 925 · see citing works

The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations

Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758 · see citing works

Antimicrobial peptides in mammalian and insect host defence

Lehrer, R. I., & Ganz, T. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80005-3 · Cited by 723 · see citing works

A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

Tang, Y., Yuan, J. J., Ösapay, G., Ősapay, K., Tran, D., Miller, C. J., Ouellette, A. J., & Selsted, M. E. (1999) · Science · doi:10.1126/science.286.5439.498 · Cited by 698 · see citing works

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

Chertov, O., Michiel, D. F., Xu, L., Wang, J., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., & Oppenheim, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2935 · Cited by 548 · see citing works

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.9 · Cited by 501 · see citing works

Monocyte-chemotactic activity of defensins from human neutrophils.

Territo, M., Ganz, T., Selsted, M. E., & Lehrer, R. I. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114394 · Cited by 489 · see citing works

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

Conejo-Garcia, J. R., Krause, A., Schulz, S., Rodríguez-Jiménez, F. J., Klüver, E., Adermann, K., Forssmann, U., Frimpong‐Boateng, A., Bals, R., & Forssmann, W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0865fje · Cited by 469 · see citing works

Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation

Sallusto, F., & Lanzavecchia, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.611 · Cited by 468 · see citing works

Identification of a novel, multifunctional *-defensin (human *-defensin 3) with specific antimicrobial activity

Conejo-Garcia, J. R., Jaumann, F., Schulz, S., Krause, A., Rodríguez-Jiménez, J., Forssmann, U., Adermann, K., Klüver, E., Vogelmeier, C. F., Becker, D., et al. (2001) · Cell and Tissue Research · doi:10.1007/s004410100433 · Cited by 408 · see citing works

Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity

Cole, A. M., Ganz, T., Liese, A. M., Burdick, M. D., Liu, L., & Strieter, R. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.623 · Cited by 382 · see citing works

Antimicrobial peptides of vertebrates

Ganz, T., & Lehrer, R. I. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80029-0 · Cited by 374 · see citing works

Thrombocidins, Microbicidal Proteins from Human Blood Platelets, Are C-terminal Deletion Products of CXC Chemokines

Krijgsveld, J., Zaat, S. A. J., Meeldijk, J., van Veelen, P. A., Fang, G., Poolman, B., Brandt, E., Ehlert, J. E., Kuijpers, A. J., Engbers, G. H. M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.27.20374 · Cited by 339 · see citing works

The Structure of Human β-Defensin-2 Shows Evidence of Higher Order Oligomerization

Hoover, D. M., Rajashankar, K. R., Blumenthal, R., Puri, A., Oppenheim, J. J., Chertov, O., & Lubkowski, J. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006098200 · Cited by 318 · see citing works

Mechanisms for induction of acquired host immunity by neutrophil peptide defensins

Lillard, J. W., Boyaka, P. N., Chertov, O., Oppenheim, J. J., & McGhee, J. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.651 · Cited by 305 · see citing works

Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens

Biragyn, A., Surenhu, M., Yang, D., Ruffini, P. A., Haines, B. A., Klyushnenkova, E., Oppenheim, J. J., & Kwak, L. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6644 · Cited by 286 · see citing works

Paneth cell defensins: Endogenous peptide components of intestinal host defense

Ouellette, A. J., & Selsted, M. E. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.11.8836041 · Cited by 283 · see citing works

Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity

Biragyn, A., Tani, K., Grimm, M., Weeks, S., & Kwak, L. W. (1999) · Nature Biotechnology · doi:10.1038/6995 · Cited by 278 · see citing works

The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity

Yang, D., Chertov, O., & Oppenheim, J. J. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000914 · Cited by 236 · see citing works

Mouse neutrophils lack defensins

Eisenhauer, P. B., & Lehrer, R. (1992) · Infection and Immunity · doi:10.1128/iai.60.8.3446-3447.1992 · Cited by 227 · see citing works

The role of chemokines in the regulation of dendritic cell trafficking

Sozzani, S., Allavena, P., Vecchi, A., & Mantovan, A. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.1.1 · Cited by 225 · see citing works

Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells.

Chaly, Y., Paleolog, E. M., Kolesnikova, T. S., Tikhonov, I. I., Petratchenko, E. V., & Voitenok, N. N. (2000) · PubMed · Cited by 210 · see citing works

Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens

Tani, K., Murphy, W. J., Chertov, O., Salcedo, R., Koh, C. Y., Utsunomiya, I., Funakoshi, S., Asai, O., Herrmann, S. H., Wang, J. M., et al. (2000) · International Immunology · doi:10.1093/intimm/12.5.691 · Cited by 203 · see citing works

Neutrophil Defensins Induce Histamine Secretion from Mast Cells: Mechanisms of Action

Befus, A. D., Mowat, C., Gilchrist, M., Hu, J., Solomon, S., & Bateman, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.947 · Cited by 201 · see citing works

Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitro

Bastian, A., & Schäfer, H. J. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00282-8 · Cited by 161 · see citing works

Epithelial antimicrobial peptides: innate local host response elements

Schr�der, J.-M. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050004 · Cited by 159 · see citing works

Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity

Bauer, F., Schweimer, K., Klüver, E., Conejo-Garcia, J. R., Forssmann, W., ROSCH, P. J., Adermann, K., & Sticht, H. (2001) · Protein Science · doi:10.1110/ps.24401 · Cited by 152 · see citing works

Critical Role of Lipid Composition in Membrane Permeabilization by Rabbit Neutrophil Defensins

Hristova, K. A., Selsted, M. E., & White, S. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24224 · Cited by 149 · see citing works

Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches

Spahn, T. W., Fontana, A., Faria, A. M. C., Slavin, A., Eugster, H., Zhang, X., Koni, P. A., Ruddle, N. H., Flavell, R. A., Rennert, P. D., et al. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200104)31:4 · Cited by 143 · see citing works

Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production

Watering, S. V., Mannesse-Lazeroms, S. P. G., Dijkman, J. H., & Hiemstra, P. S. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.2.217 · Cited by 136 · see citing works

Evolutionary diversification of the mammalian defensins

Hughes, A. L. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050010 · Cited by 135 · see citing works

The NMR Structure of Human β-Defensin-2 Reveals a Novel α-Helical Segment,

Sawai, M. V., Jia, H. P., Liu, L., Aseyev, V. O., Wiencek, J. M., McCray, P. B., Ganz, T., Kearney, W. R., & Tack, B. F. (2001) · Biochemistry · doi:10.1021/bi002519d · Cited by 121 · see citing works

Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.

Yang, D., Howard, O. M. Z., Chen, Q., & Oppenheim, J. J. (1999) · PubMed · Cited by 103 · see citing works

Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity

Bauer, F. (2001) · Protein Science · doi:10.1110/ps.ps.24401 · Cited by 101 · see citing works

Inhibition of Activation of the Classical Pathway of Complement by Human Neutrophil Defensins

van den Berg, R. H., Faber‐Krol, M. C., van Wetering, S., Hiemstra, P. S., & Daha, M. R. (1998) · Blood · doi:10.1182/blood.v92.10.3898.422k03_3898_3903 · Cited by 99 · see citing works

Cutting Edge: Immature Dendritic Cells Generated from Monocytes in the Presence of TGF-β1 Express Functional C-C Chemokine Receptor 6

Yang, D., Howard, O. M. Z., Chen, Q., & Oppenheim, J. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1737 · Cited by 91 · see citing works

NMR Solution Structure of Murine CCL20/MIP-3α, a Chemokine That Specifically Chemoattracts Immature Dendritic Cells and Lymphocytes through Its Highly Specific Interaction with the β-Chemokine Receptor CCR6

Pérez‐Cañadillas, J. M., Zaballos, Á., Gutiérrez, J., Varona, R., Roncal, F., Albar, J. P., Márquez, G., & Bruix, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103121200 · Cited by 86 · see citing works

Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmenbrane glycoprotein gq41 of HIV-1

Prohászka, Z., ́met, K. N., Csermely, P., Hudecz, F., Mez.o, G., & ̈st, G. F. (1997) · Molecular Immunology · doi:10.1016/s0161-5890(97)00097-7 · Cited by 82 · see citing works

Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides

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Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages

Fleischmann, J., Selsted, M. E., & Lehrer, R. I. (1985) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/0732-8893(85)90035-5 · Cited by 53 · see citing works

Enhancement of phagocytosis by corticostatin I (CSI) in cultured mouse peritoneal macrophages

Ichinose, M., Asai, M., Imai, K., & Sawada, M. (1996) · Immunopharmacology · doi:10.1016/s0162-3109(96)00118-x · Cited by 29 · see citing works

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works

Cathelicidins, multifunctional peptides of the innate immunity

Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988 · see citing works

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572 · see citing works

IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways

Kao, C.-Y., Chen, Y., Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R. W., & Wu, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3482 · Cited by 424 · see citing works

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines

Uehara, A., Fujimoto, Y., Fukase, K., & Takada, H. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.02.007 · Cited by 330 · see citing works

Intracellular pharmacodynamics of antibiotics

Carryn, S., Chanteux, H., Seral, C., Mingeot-Leclercq, M.-P., Van Bambeke, F., & Tulkens, P. M. (2003) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(03)00066-7 · Cited by 201 · see citing works

Host defense function of the airway epithelium in health and disease: clinical background

Message, S. D., & Johnston, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703315 · Cited by 159 · see citing works

Antimicrobial peptides as biologic and immunotherapeutic agents against cancer: a comprehensive overview

Roudi, R., Syn, N. L., & Roudbary, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01320 · Cited by 139 · see citing works

Inducibility of the endogenous antibiotic peptide β-defensin 2 is impaired in patients with severe sepsis

Book, M., Chen, Q., Lehmann, L. E., Klaschik, S., Weber, S., Schewe, J.-C., Luepertz, M., Hoeft, A., & Stuber, F. (2007) · Critical Care · doi:10.1186/cc5694 · Cited by 37 · see citing works

An alphaherpesvirus exploits antimicrobial β-Defensins to initiate respiratory tract infection.

Van Cleemput, J., Poelaert, K. C. K., Laval, K., Vanderheijden, N., Dhaenens, M., Daled, S., Boyen, F., Pasmans, F., & Nauwynck, H. J. (2020) · Journal of Virology · doi:10.1128/jvi.01676-19 · Cited by 13 · see citing works

HUMAN DEFENSIN PEPTIDES WITH ANTIMICROBIAL PROPERTIES: AN OVERVIEW

Jha, L. L., Shah, D., & Ks, R. (2012)

Antimicrobial peptides in animals and their role in host defences

Brogden, K. A., Ackermann, M. R., McCray, P. B., & Tack, B. F. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00180-8 · Cited by 458 · see citing works

Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells

van Wetering, S., Tjabringa, G. S., & Hiemstra, P. S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0604367 · Cited by 62 · see citing works

Epithelial antimicrobial peptides in host defense against infection

Bals, R. (2000) · Respiratory Research · doi:10.1186/rr25 · Cited by 499 · see citing works

Flow Cytometry Detection of Chemokine Receptors for the Identification of Murine Monocyte and Neutrophil Subsets

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