The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients
Abstract
Type 2 diabetic subjects have an increased propensity to premature atherosclerosis. Alpha tocopherol (AT), a potent antioxidant, has several anti-atherogenic effects. There is scanty data on AT supplementation on inflammation in Type 2 diabetic subjects. The aim of the study was to test the effect of RRR-AT supplementation (1200 IU/d) on plasma C-reactive protein (CRP) and interleukin-6 (IL-6) release from activated monocyte in Type 2 diabetic patients with and without macrovascular complications compared to matched controls. The volunteers comprised Type 2 diabetic subjects with macrovascular disease (DM2-MV, n = 23), Type 2 diabetic subjects without macrovascular complications (DM2, n = 24), and matched controls (C, n = 25). Plasma high sensitive CRP (Hs-CRP) and Monocyte IL-6 were assayed at baseline, following 3 months of supplementation and following a 2 month washout phase. DM2-MV subjects have elevated HsCRP and monocyte IL-6 compared to controls. AT supplementation significantly lowered levels of C-reactive protein and monocyte interleukin-6 in all three groups. In conclusion, AT therapy decreases inflammation in diabetic patients and controls and could be an adjunctive therapy in the prevention of atherosclerosis.
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“Increased consumption of dairy products has been shown to have beneficial effects on plasma CRP and adiponectin concentrations in obese subjects (683) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [683]
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Cites
Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.98.8.731 · Cited by 1,642
The Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146
Is Type II diabetes mellitus a disease of the innate immune system?
Pickup, J. C., & Crook, M. A. (1998) · Diabetologia · doi:10.1007/s001250051058 · Cited by 1,042
Body mass index, diabetes, and C-reactive protein among U.S. adults.
Ford, E. S. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1971 · Cited by 642
Pryor, W. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00224-5 · Cited by 450
Novel Inflammatory Markers of Coronary Risk
Libby, P., & Ridker, P. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1148 · Cited by 375
Devaraj, S., & Jialal, I. (2000) · Circulation · doi:10.1161/01.cir.102.2.191 · Cited by 163
Self-citationThe effects of alpha‐tocopherol on critical cells in atherogenesis
Devaraj, S., & Jialal, I. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199802000-00004 · Cited by 110
Self-citationVitamin E Supplementation and Cardiovascular Events in High-Risk Patients
Jialal, I., & Devaraj, S. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422514 · Cited by 49
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C-Reactive Protein Elevation in Patients With Atrial Arrhythmias
Chung, M. K., Martin, D. O., Sprecher, D. L., Wazni, O. M., KANDERIAN, A. S., Carnes, C. A., Bauer, J. A., TCHOU, P. J., Niebauer, M. J., Natale, A., et al. (2001) · Circulation · doi:10.1161/hc4901.101760 · Cited by 1,386
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Jialal, I., Stein, D. T., Balis, D. S., Grundy, S. M., ADAMS-HUET, B. A., & Devaraj, S. (2001) · Circulation · doi:10.1161/01.cir.103.15.1933 · Cited by 731
Self-citationShivappa, N., Steck, S. E., Hurley, T. G., Hussey, J. R., Ma, Y., Ockene, I. S., Tabung, F. K., & Hébert, J. R. (2013) · Public Health Nutrition · doi:10.1017/s1368980013002565 · Cited by 724
Cavicchia, P. P., Steck, S. E., Hurley, T. G., Hussey, J. R., Ma, Y., Ockene, I. S., & Hébert, J. R. (2009) · Journal of Nutrition · doi:10.3945/jn.109.114025 · Cited by 638
Metadata
- Authors
- Devaraj, S., & Jialal, I.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Jialal, Ishwarlal
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 29
- Issue
- 8
- Pages
- 790-792
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2085598380
- Cited by
- 227
- References
- 9
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Center for Complementary and Integrative Health (K-24AT00596, 1 RO1 AT00005-01, R01AT000005, K24AT000596)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- alpha-tocopherol, vitamin E supplementation, type 2 diabetes, C-reactive protein, interleukin-6, monocytes, inflammation, macrovascular complications, atherosclerosis, antioxidant therapy
- MeSH terms
- Antioxidants, Arteriosclerosis, C-Reactive Protein, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Monocytes, Vitamin E, Interleukin-6, Case-Control Studies
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