Cited by 216Carcinogens and Genotoxicity AssessmentDNA Repair MechanismsRedox biology and oxidative stress

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Identification of Possible Reactive Oxygen Species Involved in Ultraviolet Radiation-Induced Oxidative DNA Damage

Zhang, Xueshu, Rosenstein, Barry S, Wang, Yan, Lebwohl, Mark, Wei, Huachen·1997·Free Radical Biology and Medicine

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Abstract

We have previously demonstrated that each region of the ultraviolet (UV) spectrum (UVA, UVB, and UVC) induces the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in purified calf thymus DNA and HeLa cells in a fluence-dependent manner. In the present study, we further characterize the possible reactive oxygen species (ROS) that are involved in the induction of 8-oxodGuo by UV radiation. Sodium azide, a singlet oxygen (1O2) scavenger though its quenching effect on HO. was also reported, inhibited 8-oxodGuo production in calf thymus DNA exposed to UVA, UVB, or UVC in a concentration-dependent fashion with maximal quenching effect of over 90% at a concentration of 10 mM. Catalase, at a concentration of 50 U/ml, reduced the yields of UVA- and UVB-induced 8-oxodGuo formation by approximately 50%, but had little effect on UVC-induced 8-oxodGuo production. In contrast, 50 U/ml of superoxide dismutase (SOD) did not affect induction of 8-oxodGuo by any portion of the UV spectrum. Hydroxyl radical (HO.) scavengers mannitol and dimethylsulfoxide (DMSO) moderately reduced the levels of 8-oxodGuo induced by UVA and UVB, but not those by UVC. Instead, mannitol and DMSO enhanced the formation of 8-oxodGuo induced by UVC. These results suggest that certain types of ROS are involved in UV-induced 8-oxodGuo formation with 1O2 playing the predominant role throughout the UV spectrum. Except for UVC, other ROS such as hydrogen peroxide (H2O2) and HO. may also be involved in UVA- and…

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Authors: Zhang, X., Rosenstein, B. S., Wang, Y., Lebwohl, M., & Wei, H.
Affiliations: City University of New York (US)
Corresponding author: Wei, Huachen
ORCID: Zhang, Xueshu
Rosenstein, Barry S
Wang, Yan
Lebwohl, Mark
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 1997-01
Volume: 23
Issue: 7
Pages: 980-985
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/s0891-5849(97)00126-3
OpenAlex: W2089811590
Cited by: 216
References: 0
Citations by year: 2026: 3 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 13 · 2013: 9 · 2012: 10
FWCI: 2.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01ca060994-03, 5r01ca061764-04)
National Cancer Institute (CA61764, CA60994)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: reactive oxygen species, ultraviolet radiation, oxidative DNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanosine, singlet oxygen, hydroxyl radicals, hydrogen peroxide, superoxide, UVA, UV-B radiation, UV-C, sodium azide, catalase, superoxide dismutase, calf thymus DNA, HeLa cells
MeSH terms: Catalase, Dimethyl Sulfoxide, DNA Damage, Mannitol, Superoxide Dismutase, Ultraviolet Rays, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress, Sodium Azide

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Identification of Possible Reactive Oxygen Species Involved in Ultraviolet Radiation-Induced Oxidative DNA Damage

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