Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reactionHiroshi Kasai, Ziro Yamaizumi, Maurice Berger, and Jean CadetCite this: J. Am. Chem. Soc. 1992, 114, 24, 9692–9694Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00050a078https://doi.org/10.1021/ja00050a078research-articleACS PublicationsRequest reuse permissionsArticle Views668Altmetric-Citations264LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
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Water reacts efficiently with guanine radical cation, and amino acids with nucleophilic groups including lysine, arginine, and serine covalently bind to C8 of guanine.
“In addition to water that was found initially to efficiently react with Gua •+ (218), several amino acids bearing a nucleophilic group, including lysine, arginine and serine were shown to covalent bind to the C8 of guanine (111,216).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [218]
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- Authors
- Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-11
- Volume
- 114
- Issue
- 24
- Pages
- 9692-9694
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1975819067
- Cited by
- 300
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 11 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 13
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Keywords
- 8-hydroxy-2'-deoxyguanosine, riboflavin, singlet oxygen, DNA oxidation, photoproducts
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