The DOI matches its Crossref record; 207 of the 211 references it cites were found in a registry or an index.
Modulation of leukocyte–endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease
Abstract
Ischemia and reperfusion (I/R) are thought to play an important role in the pathophysiology of ischemic diseases of the heart. It is now well appreciated that leukocyte-endothelial cell interactions are important determinants for I/R-induced microvascular injury and dysfunction. There is a growing body of experimental data to suggest that reactive metabolites of oxygen and nitrogen are important physiological modulators of leukocyte-endothelial cell interactions. A number of investigators have demonstrated that I/R enhances oxidant production within the microcirculation resulting in increases in leukocyte adhesion and transendothelial cell migration. Several other studies have shown that exogenous nitric oxide (NO) donors may attenuate leukocyte and platelet adhesion and/or aggregation in a number of different inflammatory conditions including I/R. The objective of this review is to discuss the physiological chemistry of reactive metabolites of oxygen and nitrogen with special attention given to those interactions that may modulate leukocyte-endothelial cell interactions, provide an overview of the evidence implicating reactive metabolites of oxygen and nitrogen as modulators of leukocyte-endothelial cell interactions in vivo, and discuss how these mechanisms may be involved in the pathophysiology of ischemic heart disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is well accepted that decreased NO levels contribute to endothelial cell dysfunction, atherosclerotic plaque development, arteriosclerosis, vessel restenosis, peripheral vascular disease, and ischemia-reperfusion injury [14, 15, 138–140].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [140]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–207 of 207
Sappey, C., Boelaert, J. R., Legrand-Poels, S., Grady, R. W., & Piette, J. G. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1394 · Cited by 22
Endothelium-derived nitric oxide
Moncada, S. (1999) · UCL Discovery (University College London) · Cited by 21
Coronary Vascular and Antiplatelet Effects of Peroxynitrite in Human Tissues
Ku, D. D., Liu, S., & Dai, J. (1995) · Endothelium · doi:10.3109/10623329509024673 · Cited by 17
Neutrophil Membrane Sulfhydryl Groups Are Involved in Stimulated Neutrophil Adherence to Endothelium
Schwartz, B. R., & Harlan, J. M. (1989) · Journal of Leukocyte Biology · doi:10.1002/jlb.45.3.177 · Cited by 13
Mechanisms of Lactoferrin‐induced Leukocyte‐Endothelial Cell Adhesion in Postcapillary Venules
Asako, H., Kurose, I., Wolf, R. E., & Granger, D. N. (1994) · Microcirculation · doi:10.3109/10739689409148259 · Cited by 10
Self-citationHemoprotein-dependent production of a neutrophil-activating factor from arachidonic acid
Wallace, J. L., Rioux, K. P., McKnight, W., Carter, L., Jourd’heuil, D., Meddings, J. B., Zimmerman, B. J., Granger, D. N., & Grisham, M. B. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.5.h1546 · Cited by 6
Self-citationWink, D. A., Wink, C. B., Nims, R. W., & Ford, P. C. (1994) · Environmental Health Perspectives · doi:10.2307/3431754 · Cited by 5
Research works printed but not linked: 15
- Gaboury, 1993, Nitric oxide prevents leukocyte adherence, Am. J. Physiol., 265, H862
- Paller, 1988, Hemoglobin and myoglobin-induced acute renal failure in rats, Am. J. Physiol., 255, F539
- Koppenol, 1996, Synthesis of peroxynitrite, Meth. Enz., 269, 296
- Asako, 1992, Indomethacin-induced leukocyte adhesion in mesenteric venules, Am. J. Physiol., 262, G903
- Inauen, 1990, Anoxia-reoxygenation-induced, neutrophil-mediated endothelial cell injury, Am. J. Physiol., 259, H925
- Milhoan, 1992, Hypoxia induces endothelial cells to increase their adherence for neutrophils, Am. J. Physiol., 263, H956
- Manning, 1994, Transcription factor NF-κB, Annu. Rep. Med. Chem., 28, 235
- Kurose, 1997, Ischemia/reperfusion-induced microvascular dysfunction, Am. J. Physiol., 272, H2976
- Kubes, 1993, Nitric oxide-induced microvascular permeability alterations, Am. J. Physiol., 265, H1910
- Seekamp, 1993, Requirements for neutrophil products and l-arginine in ischemia-2Dreperfusion injury, Am. J. Pathol., 142, 1
- Ma, 1993, Dimished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium, Circ. Res., 72, 403, 10.1161/01.RES.72.2.403 · DOI
- Mehta, 1989, Attenuated coronary relaxation after reperfusion, Am. J. Physiol., 257, H1240
- Rubanyi, 1986, Superoxide anions and hyperoxia inactivate endothelium-derived relacing factor, Am. J. Physiol., 250, H822
- Shirato, 1988, Superoxide dismutase (single dose) delays rather than prevents necrosis in reperfused rabbit heart, FASEB J, 2, A918
- Mathies, 1992, Role of l-arginine–nitric oxide pathway in myocardial reoxygenation injury, Am. J. Physiol., 262, H616
Cited by
Sorted by citations
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
Obstructive sleep apnoea syndrome – an oxidative stress disorder
Lavie, L. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0261 · Cited by 993
Structure and function of xanthine oxidoreductase: where are we now?
Harrison, R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00956-5 · Cited by 807
REVIEW: Ischemia—Reperfusion Injury of the Intestine and Protective Strategies Against Injury
Mallick, I. H., Yang, W., Winslet, M. C., & Seifalian, A. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000042232.98927.91 · Cited by 649
The Endothelial Biology of Sickle Cell Disease: Inflammation and a Chronic Vasculopathy
Hebbel, R. P., Osarogiagbon, R. U., & Kaul, D. K. (2004) · Microcirculation · doi:10.1080/10739680490278402 · Cited by 464
Metadata
- Authors
- Grisham, M. B., Granger, D. N., & Lefer, D. J.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Grisham, Matthew B.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 25
- Issue
- 4-5
- Pages
- 404-433
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2094525668
- Cited by
- 293
- References
- 211
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 11 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 11
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk047663-06)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01 DK-43785, DK-47663, P01DK043785)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, reactive nitrogen species, leukocyte-endothelium interaction, ischemia-reperfusion injury, ischemic heart disease, nitric oxide donors, leukocyte adhesion, transendothelial migration, platelet aggregation, microvascular damage, oxidative stress
- MeSH terms
- Animals, Cell Adhesion, Endothelium, Vascular, Humans, Iron, Leukocytes, Nitric Oxide, Oxidation-Reduction, Myocardial Reperfusion Injury, Myocardial Ischemia, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
