The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Long-Term Repetitive Transcranial Magnetic Stimulation Increases the Expression of Brain-Derived Neurotrophic Factor and Cholecystokinin mRNA, but not Neuropeptide Tyrosine mRNA in Specific Areas of Rat Brain
Open accessAbstract
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic effects are still unknown. We investigated the effects of long-term rTMS on the expression of brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like immunoreactivity was markedly increased in the same areas. A significant increase in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in contrast, was not altered. The present results suggest that BDNF may contribute to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in BDNF and CCK expression are similar to those reported after antidepressant drug treatment and electroconvulsive seizures, suggesting that a common molecular mechanism may underlie different antidepressant treatment strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Such induced plasticity (iPlasticity) (14) has been hypothesized to play a major role in the actions of essentially all antidepressant treatments including slow-acting traditional antidepressants (15), transcranial magnetic stimulation (16), electroconvulsive therapy (15, 17), exercise (18), and acute sleep deprivation (19).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,478
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Pascual-Leone, A., Rubio, B., Pallardó, F., & Catalá, M. D. (1996) · The Lancet · doi:10.1016/s0140-6736(96)01219-6 · Cited by 1,229
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206
Current advances and trends in the treatment of depression
Blier, P., & de Montigny, C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90315-8 · Cited by 1,113
Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02295.1997 · Cited by 1,097
CREB: A Major Mediator of Neuronal Neurotrophin Responses
Finkbeiner, S. M., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80395-5 · Cited by 959
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841
Cited by
Sorted by citations
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Transcranial magnetic stimulation: new insights into representational cortical plasticity
Siebner, H. R., & Rothwell, J. C. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1234-2 · Cited by 777
Brain metabolism in health, aging, and neurodegeneration
Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752
Ten years of theta burst stimulation in humans: Established knowledge, unknowns and prospects
Suppa, A., Huang, Y.-Z., Funke, K., Ridding, M. C., Cheeran, B., Di Lazzaro, V., Ziemann, U., & Rothwell, J. C. (2016) · Brain Stimulation · doi:10.1016/j.brs.2016.01.006 · Cited by 609
Therapeutic application of repetitive transcranial magnetic stimulation: a review
Wassermann, E. M., & Lisanby, S. H. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00585-5 · Cited by 601
Metadata
- Authors
- Müller, M.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Müller, M
- ORCID
- Müller, M
- Venue
- Neuropsychopharmacology
- Published
- 2000-08
- Volume
- 23
- Issue
- 2
- Pages
- 205-215
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2035353363
- Cited by
- 292
- References
- 69
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 18 · 2015: 18 · 2014: 17 · 2013: 12 · 2012: 14
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Neuropsychopharmacology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- repetitive transcranial magnetic stimulation, brain-derived neurotrophic factor, cholecystokinin, neuropeptide tyrosine, mRNA expression, neuroprotection, hippocampus, piriform cortex, parietal cortex, antidepressant mechanism, electroconvulsive therapy, rat brain
- MeSH terms
- Animals, Brain, Cerebral Cortex, Cholecystokinin, Electric Stimulation, Hippocampus, Male, Neuropeptide Y, Olfactory Pathways, Parietal Lobe, RNA, Messenger, Time, Rats, Wistar, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Transcranial Magnetic Stimulation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
