Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport
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A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature rat BDNF protein. These combined data revealed (1) groups of cell bodies containing diffuse BDNF-ir throughout the CNS that were strongly correlated with fields of cells containing BDNF mRNA; (2) varying degrees of BDNF-ir outside of cell bodies, in what appeared to be fibers and/or terminals; and (3) many regions containing extremely heavy BDNF-immunoreactive fiber/terminal labeling that lacked BDNF mRNA (e.g., medial habenula, central nucleus of the amygdala, bed nucleus of stria terminalis, lateral septum, and spinal cord). The latter observation suggested that in these regions BDNF was derived from anterograde axonal transport by afferent systems. In the two cases in which this hypothesis was tested by the elimination of select afferents, BDNF immunostaining was completely eliminated. These data, along with the observation that BDNF-ir was rarely found within dendrites or fibers en passage, suggest that BDNF protein produced in adult CNS neurons is polarized primarily along axonal processes and is preferentially stored in terminals within the innervation target.
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BDNF is involved in multiple levels of neuroplasticity like synaptic modulation, adult neurogenesis, and dendritic growth.
“BDNF is involved in multiple levels of neuroplasticity like synaptic modulation, adult neurogenesis, and dendritic growth (29–32).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [29]
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- Authors
- Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M., & Varon, S.
- Affiliations
- University of California San Diego (US)
- University of California, Irvine (US)
- Amgen (United States) (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-04-01
- Volume
- 17
- Issue
- 7
- Pages
- 2295-2313
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6573520
- OpenAlex
- W2117830068
- Cited by
- 1,097
- References
- 57
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 25 · 2023: 23 · 2022: 41 · 2021: 38 · 2020: 32 · 2019: 39 · 2018: 40 · 2017: 42 · 2016: 49 · 2015: 58 · 2014: 44 · 2013: 52 · 2012: 48
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns016349-16, 5k02mh000974-03, 5r01ns026748-10)
- National Institute of Mental Health (MH00974)
- National Institute of Neurological Disorders and Stroke (NS-26748, NS 16349)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, anterograde axonal transport, BDNF mRNA, central nervous system, afferent systems, medial habenula, central amygdala, bed nucleus of the stria terminalis, lateral septum, spinal cord
- MeSH terms
- Animals, Axonal Transport, Brain, Female, Immunohistochemistry, Male, Nerve Fibers, Neurons, Organ Specificity, Reference Values, RNA, Messenger, Spinal Cord, Rats, Sprague-Dawley, In Situ Hybridization, DNA, Complementary, Brain-Derived Neurotrophic Factor, Rats
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