The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
PET Measures of Amphetamine-Induced Dopamine Release in Ventral versus Dorsal Striatum
Abstract
Regional differences in dextroamphetamine (AMPH)-induced dopamine (DA) release in the baboon striatum were assessed using positron emission tomographic (PET) measures of [11C]raclopride specific binding to DA D2/D3 receptors acquired before and after AMPH administration. The magnitude of the reduction in [11C]raclopride binding, following AMPH administration, was two-fold greater in the anteroventral striatum (comprised of ventral caudate, anteroventral putamen, and nucleus accumbens) than the dorsal striatum (dorsal caudate). A simulation study demonstrated that any potential biases due to resolution (partial volume) and alignment effects were significantly smaller than the magnitude of the observed results. These regional differences in the sensitivity of AMPH are compatible with microdialysis evidence in rats indicating that the magnitude of DA release in response to AMPH concentrations in the range tested is greater in ventral than dorsal striatal regions. Post hoc tests involving measures in other striatal regions showed that the baseline DA D2/D3 binding was highest and the correlation between AMPH dose and change in [11C]raclopride binding most significant in the putamen.
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Reply to “The Value of Functional PET in Quantifying Neurotransmitter Dynamics”
Morris, E. D., Emvalomenos, G. M., Hoye, J., & Meikle, S. R. (2025) · Journal of Nuclear Medicine · doi:10.2967/jnumed.125.269473
Mansouri-Guilani, N. (2017) · theses.fr (ABES) · doi:10.70675/99ced3b5zeac6z4eb2z8e6cz01bcad7cf2d9
Metadata
- Authors
- Drevets, W.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Drevets, W
- ORCID
- Drevets, W
- Venue
- Neuropsychopharmacology
- Published
- 1999-12
- Volume
- 21
- Issue
- 6
- Pages
- 694-709
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2062446797
- Cited by
- 122
- References
- 64
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- amphetamine, dopamine release, striatum, ventral striatum, dorsal striatum, [11C]raclopride, D2/D3 receptors, baboons, nucleus accumbens, caudate nucleus, partial volume correction, microdialysis
- MeSH terms
- Amphetamine, Animals, Carbon Radioisotopes, Caudate Nucleus, Corpus Striatum, Dopamine, Female, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Papio, Putamen, Tomography, Emission-Computed, Receptors, Dopamine D1, Receptors, Dopamine D2, Raclopride, Receptors, Dopamine D3, Rats
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