The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Nicotinic receptors in the brain. Links between molecular biology and behavior
Open accessAbstract
Molecular cloning has elucidated the sequence of a family of acetylcholine receptor subunits that are activated by nicotine. Subsequent studies on the localization of individual subunits and the physiological properties of nicotinic subunit combinations in vitro, have led to identification of subunit compositions of nicotinic receptors that may function in vivo, as the native receptor. A particular challenge for the field has been to use these molecular data to determine which individual nicotinic receptor subtype is responsible for mediating each of the behavioral effects of nicotine. Human and animal studies have shown that nicotine is reinforcing and likely responsible for the addictive properties of tobacco. In addition, nicotine has been shown to have effects on locomotion, cognition, affect, and pain sensitivity. Recent studies combining the techniques of molecular biology, pharmacology, electrophysiology, and behavioral analysis to analyze knock out mice that lack individual subunits of the nicotinic acetylcholine receptor, have helped identify the role of specific nicotinic subunits in some of these complex behaviors. These studies could ultimately be useful in designing specific nicotinic receptor agonists and antagonists that may have uses in the clinic.
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“ACh signals through two classes of receptors: metabotropic muscarinic receptors (mAChRs) and ionotropic nicotinic receptors (nAChRs) (reviewed in (Picciotto et al., 2000; Wess, 2003a)).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Picciotto et al., 2000
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970
Lou, X., Chen, G., Yan, L., Ma, J. Z., Zhu, J., Elston, R. C., & Li, M. D. (2007) · The American Journal of Human Genetics · doi:10.1086/518312 · Cited by 564
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Cigarette smoking and depression: tests of causal linkages using a longitudinal birth cohort
Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.065912 · Cited by 477
Metadata
- Authors
- Picciotto, M.
- Affiliations
- Yale University (US)
- Corresponding author
- Picciotto, M
- ORCID
- Picciotto, M
- Venue
- Neuropsychopharmacology
- Published
- 2000-05
- Volume
- 22
- Issue
- 5
- Pages
- 451-465
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2091673195
- Cited by
- 354
- References
- 165
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 16 · 2015: 14 · 2014: 13 · 2013: 15 · 2012: 10
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (DA10455)
- National Institute on Drug Abuse (DA-00167, DA 10455, DA-07290, K12DA000167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, nicotinic receptor subunits, nicotine, nicotine dependence, tobacco, receptor knockout mice, locomotion, cognition, affect, pain sensitivity
- MeSH terms
- Animals, Behavior, Humans, Models, Neurological, Molecular Biology, Receptors, Nicotinic, Mice, Knockout, Mice
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