Perception of prognostic risk in patients with multiple sclerosis: the relationship with anxiety, depression, and disease-related distress
Abstract
Objective The aim of the study was to investigate the impact of perception of prognostic risk on anxiety, depression, and disease-related distress in patients with multiple sclerosis (MS). Study design and setting Perceived risk and perceived seriousness of the 2-year, 10-year, and lifetime prognosis of wheelchair dependence, disability status, anxiety, depression, and disease-related distress were assessed in 101 patients. Distress was measured as the intrusion and avoidance of MS-related thoughts and feelings. Results Patients with higher perceptions of 2-year, 10-year, or lifetime risk were bothered by more intrusion of MS-related thoughts and feelings. Only higher perception of the 2-year risk of wheelchair dependence was significantly related with higher levels of anxiety, depression, and avoidance. Similarly, higher perception of the seriousness of wheelchair dependence was consistently associated with more intrusion and avoidance, but only perceived seriousness of the 2-year prospect of wheelchair dependence was significantly correlated with anxiety and depression. All relations were independent of clinically assessed disability status. Conclusion Perceptions of the short-term risk and seriousness of wheelchair dependence were significantly related to anxiety, depression, and disease-related distress in patients with MS. These findings underscore the importance of informing patients with chronic disorders about the short-term prognosis of important long-term consequenc…
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No cerebral localization has been specifically associated with anxiety in multiple sclerosis, unlike depression which is more frequent after right or left frontotemporal damage.
“Jusqu'à présent, aucune localisation cérébrale n'a été spécifiquement associée à l'anxiété dans la sclérose en plaques, à l'inverse de la dépression qui serait plus fréquente suite à une atteinte fronto-temporale droite [36] ou gauche [37].”
From Prise en charge des troubles anxieux dans le cadre d'atteintes neurologiques (2004) · cites this paper as [37]
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Herrmann, C. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(96)00216-4 · Cited by 2,885 · see citing works
Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects
Zorzon, M., de Masi, R., Nasuelli, D., Ukmar, M., Pozzi Mucelli, R., Cazzato, G., Bratina, A., & Zivadinov, R. (2001) · Journal of Neurology · doi:10.1007/s004150170184 · Cited by 249 · see citing works
Depression and quality of life in multiple sclerosis: Depression and QoL in MS
Fruewald, S., Loeffler-Stastka, H., Eher, R., Saletu, B., & Baumhacki, U. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.00022.x · Cited by 211 · see citing works
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Prospective Associations Between Emotional Distress and Poor Outcomes in Type 2 Diabetes
Aikens, J. E. (2012) · Diabetes Care · doi:10.2337/dc12-0181 · Cited by 279 · see citing works
A systematic review of anxiety amongst people with Multiple Sclerosis
Butler, E., Matcham, F., & Chalder, T. (2016) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2016.10.003 · Cited by 111 · see citing works
Prise en charge des troubles anxieux dans le cadre d'atteintes neurologiques
(2004) · Schweizer Archiv fur Neurologie und Psychiatrie · doi:10.4414/sanp.2004.01536 · Cited by 1 · see citing works
- Authors
- Janssens, A. C. J. W., van Doorn, P. A., de Boer, J. B., van der Meché, F. G. A., Passchier, J., & Hintzen, R. Q.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Hintzen, Rogier Q
- Venue
- Journal of Clinical Epidemiology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 57
- Issue
- 2
- Pages
- 180-186
- ISSN
- 0895-4356 (ISSN-L)
- OpenAlex
- W2029647751
- Cited by
- 69
- References
- 3
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- multiple sclerosis, anxiety, depression, wheelchair dependence, disability progression
- MeSH terms
- Adult, Anxiety, Mental Disorders, Depression, Female, Humans, Life Style, Male, Multiple Sclerosis, Patient Education as Topic, Perception, Prognosis, Risk
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