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Cited by 76Blood Pressure and Hypertension StudiesSodium Intake and HealthNutritional Studies and Diet

The DASH diet enhances the blood pressure response to losartan in hypertensive patients

Conlin, P·2003·American Journal of Hypertension
DOI 10.1016/s0895-7061(03)00056-6
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Abstract

BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet, which emphasizes fruits, vegetables, and low fat dairy products, significantly lowers blood pressure (BP). We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension. METHODS: A total of 55 hypertensive participants were randomly assigned to 8 weeks of controlled feeding with either a control diet or the DASH diet. Within each diet arm, participants received losartan 50 mg daily or placebo for 4 weeks each, in double blind, randomized, cross-over fashion. Twenty-four-hour ambulatory BP (ABP) was measured at the end of a 2-week run-in period (baseline) and after each 4-week intervention period. RESULTS: There was no significant change in ABP during the placebo period on the control diet (n = 28) (-2.3 +/- 1.5/-1.6 +/- 1.0 mm Hg), but there was a significant reduction in systolic ABP (-5.3 +/- 1.5 mm Hg, P <.05) and no change in DBP (-2.5 +/- 1.0 mm Hg) on the DASH diet (n = 27). Losartan significantly reduced ABP on the control diet (-6.7 +/- 1.5/-3.7 +/- 1.0 mm Hg, P <.05) and to a greater extent on the DASH diet (-11.7 +/- 1.5/-6.9 +/- 1.0 mm Hg, P <.05 versus basal and control diet) particularly in African Americans. On the DASH diet, DeltaSBP on losartan was inversely related to basal plasma renin activity (n = -0.53, P =.004). CONCLUSIONS: The DASH diet enhances the ABP response to losartan in essential hypertension. This effect is particularly marked in African Americans.

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  • The addition of healthy behaviors, such as a prudent diet and regular exercise, to either antihypertensive or lipid-lowering drug therapy in other populations reduced risk factors such as systolic and diastolic blood pressure, LDL cholesterol, and C-reactive protein compared with drug therapy alone.

    “The addition of healthy behaviors, such as a prudent diet and regular exercise, to either antihypertensive or lipid-lowering drug therapy in other populations reduced risk factors, such as systolic and diastolic blood pressure 33,34 and low-density lipoprotein cholesterol, 35 as well as the inflammatory biomarker C-reactive protein, 36 compared with drug therapy alone.”

    From Healthy Lifestyle Factors in the Primary Prevention of Coronary Heart Disease Among Men: Benefits Among Users and Nonusers of Lipid-Lowering and Antihypertensive Medications (2006) · cites this paper as [33]

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Authors
Conlin, P.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Conlin, P
ORCID
Conlin, P
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2003-05
Volume
16
Issue
5
Pages
337-342
ISSN
0895-7061 (ISSN-L)
DOI
10.1016/s0895-7061(03)00056-6
OpenAlex
W2007659191
Cited by
76
References
28
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
4.61
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Brigham and Women's Hospital (M01 RR02635)
  • Johns Hopkins University
  • National Institutes of Health (1u01hl057139-01, 1u01hl057173-01, RR‐02635, RR00722)
  • National Heart, Lung, and Blood Institute (HL 03857, HL57139, HL57114, HL57173)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK63214, K24DK063214)
  • National Center for Research Resources (M01 RR 02635, M01RR000722, M01-RR00722, M01RR002635)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
DASH diet, losartan, essential hypertension, blood pressure response, antihypertensive efficacy, plasma renin activity, African Americans, ambulatory blood pressure, dietary intervention, angiotensin receptor blockers
MeSH terms
Adult, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Diastole, Diet, Double-Blind Method, Female, Humans, Hypertension, Male, Middle Aged, Potassium, Renin, Systole, Biomarkers, Treatment Outcome, Cross-Over Studies, Losartan

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