The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy
Abstract
The renin-angiotensin-aldosterone system is one of the most important systems in cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is already a very successful drug target for the therapy of these diseases. However, angiotensins are generated not only in the plasma but also locally in tissues from precursors and substrates either locally expressed or imported from the circulation. In most areas of the brain, only locally generated angiotensins can exert effects on their receptors owing to the blood-brain barrier. Other tissue renin-angiotensin-aldosterone systems are found in cardiovascular organs such as kidney, heart, and vessels and play important roles in the function of these organs and in the deleterious actions of hypertension and diabetes on these tissues. Novel components with mostly opposite actions to the classical renin-angiotensin-aldosterone systems have been described and need functional characterization to evaluate their suitability as novel drug targets.
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Cites
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Cited by
Dysregulated Renin–Angiotensin–Aldosterone System Contributes to Pulmonary Arterial Hypertension
de Man, F. S., Tu, L., Handoko, M. L., Rain, S., Ruiter, G., François, C., Schalij, I., Dorfmüller, P., Simonneau, G., Fadel, E., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0411oc · Cited by 346
Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based
Fioranelli, M., Bottaccioli, A. G., Bottaccioli, F., Bianchi, M., Rovesti, M., & Roccia, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02031 · Cited by 302
Emergence and evolution of the renin-angiotensin-aldosterone system
Fournier, D., Luft, F. C., Bader, M., Ganten, D., & Andrade-Navarro, M. A. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0894-z · Cited by 165
Vaidya, A., & Williams, J. S. (2012) · Metabolism · doi:10.1016/j.metabol.2011.09.007 · Cited by 151
Nikolic, S. B., Sharman, J. E., Adams, M. J., & Edwards, L. M. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000168 · Cited by 79
Metadata
- Authors
- Bader, M.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2010-02-01
- Volume
- 50
- Issue
- 1
- Pages
- 439-465
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2157466080
- Cited by
- 345
- References
- 9
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bader, M. (2010). Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.010909.105610
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
