The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Rapid Reuse of Readily Releasable Pool Vesicles at Hippocampal Synapses
Open accessAbstract
Functional presynaptic vesicles have been subdivided into readily releasable (RRP) and reserve (RP) pools. We studied recycling properties of RRP vesicles through differential retention of FM1-43 and FM2-10 and by varying the time window for FM dye uptake. Both approaches indicated that vesicles residing in the RRP underwent rapid endocytosis (tau approximately 1s), whereas newly recruited RP vesicles were recycled slowly (tau approximately 30 s). With repeated challenges (hypertonic or electrical stimuli), the ability to release neurotransmitter recovered 10-fold more rapidly than restoration of FM2-10 destaining. Finding neurotransmission in the absence of destaining implied that rapidly endocytosed RRP vesicles were capable of reuse, a process distinct from repopulation from the RP. Reuse would greatly expand the functional capabilities of a limited number of vesicles in CNS terminals, particularly during intermittent bursts of activity.
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Cites
Quantitative ultrastructural analysis of hippocampal excitatory synapses
Schikorski, T., & Stevens, C. F. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05858.1997 · Cited by 997
Cited by
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Rizzoli, S. O., & Betz, W. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1583 · Cited by 975
Cabin, D. E., Shimazu, K., Murphy, D., Cole, N. B., Gottschalk, W., McIlwain, K. L., Orrison, B., Chen, A., Ellis, C. E., Paylor, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08797.2002 · Cited by 865
Clathrin-Mediated Endocytosis Is the Dominant Mechanism of Vesicle Retrieval at Hippocampal Synapses
Granseth, B., Odermatt, B., Royle, S. J., & Lagnado, L. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.029 · Cited by 659
Metadata
- Authors
- Pyle, J. L., Kavalali, E. T., Piedras-Rentería, E. S., & Tsien, R. W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 28
- Issue
- 1
- Pages
- 221-231
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2071358119
- Cited by
- 345
- References
- 1
- FWCI
- 9.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pyle, J. L., Kavalali, E. T., Piedras-Rentería, E. S., & Tsien, R. W. (2000). Rapid Reuse of Readily Releasable Pool Vesicles at Hippocampal Synapses. Neuron. https://doi.org/10.1016/s0896-6273(00)00098-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
