The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones
Open accessAbstract
Actin filaments assembled at the leading edge of neuronal growth cones are centripetally transported via retrograde F-actin flow, a process fundamental to growth cone guidance and other forms of directed cell motility. Here we investigated the role of myosins in retrograde flow, using two distinct modes of myosin inhibition: microinjection of NEM inactivated myosin S1 fragments, or treatment with 2,3-butanedione-2-monoxime, and inhibitor of myosin ATPase. Both treatments resulted in dose-dependent attenuation of retrograde F-actin flow and growth of filopodia. Growth was cytochalasin sensitive and directly proportional to the degree of myosin inhibition, suggesting that retrograde flow results from superimposition of two independent processes: actin assembly and myosin-based filament retraction. These results provide the first direct evidence for myosin involvement in neuronal growth cone function.
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Forscher, P., & Smith, S. J. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1505 · Cited by 854
Self-citationMooseker, M. S., & Cheney, R. E. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.003221 · Cited by 370
Self-citationNovel form of growth cone motility involving site-directed actin filament assembly
Forscher, P., Lin, C. H., & Thompson, C. (1992) · Nature · doi:10.1038/357515a0 · Cited by 153
Self-citation
Cited by
Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages
Choquet, D., Felsenfeld, D. P., & Sheetz, M. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81856-5 · Cited by 1,245
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
Dent, E. W., & Gertler, F. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00633-0 · Cited by 893
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
Dent, E. W., Gupton, S. L., & Gertler, F. B. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001800 · Cited by 649
Cellular Control of Actin Nucleation
Welch, M. D., & Mullins, R. D. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.040202.112133 · Cited by 517
Metadata
- Authors
- Lin, C. H., Espreafico, E. M., Mooseker, M. S., & Forscher, P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 16
- Issue
- 4
- Pages
- 769-782
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2169622416
- Cited by
- 407
- References
- 3
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lin, C. H., Espreafico, E. M., Mooseker, M. S., & Forscher, P. (1996). Myosin Drives Retrograde F-Actin Flow in Neuronal Growth Cones. Neuron. https://doi.org/10.1016/s0896-6273(00)80097-5
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