The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Cellular Control of Actin Nucleation
Abstract
▪ Abstract Eukaryotic cells use actin polymerization to change shape, move, and internalize extracellular materials by phagocytosis and endocytosis, and to form contractile structures. In addition, several pathogens have evolved to use host cell actin assembly for attachment, internalization, and cell-to-cell spread. Although cells possess multiple mechanisms for initiating actin polymerization, attention in the past five years has focused on the regulation of actin nucleation—the formation of new actin filaments from actin monomers. The Arp2/3 complex and the multiple nucleation-promoting factors (NPFs) that regulate its activity comprise the only known cellular actin-nucleating factors and may represent a universal machine, conserved across eukaryotic phyla, that nucleates new actin filaments for various cellular structures with numerous functions. This review focuses on our current understanding of the mechanism of actin nucleation by the Arp2/3 complex and NPFs and how these factors work with other cytoskeletal proteins to generate structurally and functionally diverse actin arrays in cells.
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Cites
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Caron, E., & Hall, A. (1998) · Science · doi:10.1126/science.282.5394.1717 · Cited by 1,019
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
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Cited by
Harnessing actin dynamics for clathrin-mediated endocytosis
Kaksonen, M., Toret, C. P., & Drubin, D. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1940 · Cited by 706
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Actin Assembly and Endocytosis: From Yeast to Mammals
Engqvist-Goldstein, Å. E. Y., & Drubin, D. G. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.093127 · Cited by 572
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
Watson, R. T., Kanzaki, M., & Pessin, J. E. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0011 · Cited by 448
The Physics of Filopodial Protrusion
Mogilner, A., & Rubinstein, B. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.056515 · Cited by 420
Metadata
- Authors
- Welch, M. D., & Mullins, R. D.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2002-11
- Volume
- 18
- Issue
- 1
- Pages
- 247-288
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2105503408
- Cited by
- 517
- References
- 8
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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