The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
Open accessAbstract
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion. Over the past two decades, our knowledge of the many guidance cues, receptors, and downstream signaling cascades involved in neuronal outgrowth and guidance has increased dramatically. Less is known, however, about how those cascades of information converge and direct appropriate remodeling and interaction of cytoskeletal polymers, the ultimate effectors of movement and guidance. During development, much of the communication that occurs between environmental guidance cues and the cytoskeleton takes place at the growing tip of the axon, the neuronal growth cone. Several articles on this topic focus on the "input" to the growth cone, the myriad of receptor types, and their corresponding cognate ligands. Others investigate the signaling cascades initiated by receptors and propagated by second messenger pathways (i.e., kinases, phosphatases, GTPases). Ultimately, this plethora of information converges on proteins that associate directly with the actin and microtubule cytoskeletons. The role of these cytoskeletal-associated proteins, as well as the cytoskeleton itself in axon outgrowth and guidance, is the subject of this article.
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Cites
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Cited by
Elbaum-Garfinkle, S., Kim, Y., Szczepaniak, K., Chen, C. C.-H., Eckmann, C. R., Myong, S., & Brangwynne, C. P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504822112 · Cited by 1,278
Comparison of the Force Exerted by Hippocampal and DRG Growth Cones
Amin, L., Ercolini, E., Ban, J., & Torre, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073025 · Cited by 273
Schiweck, J., Eickholt, B. J., & Murk, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00261 · Cited by 223
The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders
Lasser, M., Tiber, J., & Lowery, L. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00165 · Cited by 201
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia
Bernier, L.-P., Bohlen, C. J., York, E. M., Choi, H. B., Kamyabi, A., Dissing-Olesen, L., Hefendehl, J. K., Collins, H. Y., Stevens, B., Barres, B. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.010 · Cited by 211
Metadata
- Authors
- Dent, E. W., Gupton, S. L., & Gertler, F. B.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-11-24
- Volume
- 3
- Issue
- 3
- Pages
- a001800-a001800
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W4299138771
- Cited by
- 649
- References
- 90
- Type
- posted content
- Language
- en
- Open access
- bronze
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