The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System
Open accessAbstract
Carbon monoxide (CO) is an activator of soluble guanylyl cyclase and is implicated as a neuronal messenger. CO production, nitric oxide synthase (NOS) activity, and guanosine 3',5'-monophosphate (cGMP) levels were quantitated in cerebellar granule cell cultures. Metabolic labeling experiments enabled the direct measurement of neuronal CO production in vitro. CO production is significant, and peaked during early stages of culture. NOS activity and cGMP levels synchronously increased as cells matured. Whereas inhibition of NOS depleted cGMP in mature cultures, inhibitors of CO production potentiated the nitric oxide (NO)-mediated cGMP increase. Exogenous CO at similar concentrations to endogenous levels blocked the NO-mediated cGMP increase. These results directly demonstrate that endogenous neuronal CO production is high and indicate that while NO is the major regulator of cGMP in these neurons, CO may modulate the NO-cGMP signaling system.
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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Stone, J. R., & Marletta, M. A. (1994) · Biochemistry · doi:10.1021/bi00184a036 · Cited by 647
Conformation, co-operativity and ligand binding in human hemoglobin
Cassoly, R., & Gibson, Q. H. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90382-4 · Cited by 259
Cited by
Guanylate cyclase and the ⋅NO/cGMP signaling pathway
Denninger, J. W., & Marletta, M. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00024-9 · Cited by 1,040
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
Heme Oxygenase-1: The “Emerging Molecule” Has Arrived
Morse, D., & Choi, A. M. K. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4862 · Cited by 532
Neural roles for heme oxygenase: Contrasts to nitric oxide synthase
Barañano, D. E., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191351298 · Cited by 294
Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
Petrache, I., Otterbein, L. E., Alam, J., Wiegand, G. W., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.2.l312 · Cited by 293
Metadata
- Authors
- Ingi, T., Cheng, J., & Ronnett, G. V.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 16
- Issue
- 4
- Pages
- 835-842
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1994780702
- Cited by
- 244
- References
- 3
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ingi, T., Cheng, J., & Ronnett, G. V. (1996). Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System. Neuron. https://doi.org/10.1016/s0896-6273(00)80103-8
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