The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Structural Organization of the Synaptic Exocytosis Core Complex
Open accessAbstract
Syntaxin, vesicle-associated membrane protein (VAMP), and synaptosome-associated protein of 25 kDa (SNAP-25) form a ternary "core complex" central to the process of synaptic vesicle docking and fusion. Several lines of evidence support the hypothesis that the proteins assemble in a coiled-coil structure, but the alignment of alpha helices in this coil and the overall conformation of the coil are unknown. We employ the technique of fluorescence resonance energy transfer (FRET) to investigate the alignment between syntaxin and VAMP. With the acceptor probe coupled to the amino-terminal end of the VAMP coiled-coil domain, the donor probe fluorescence is quenched to a greater extent when it is on the amino-terminal end of the syntaxin H3 domain than when it is on the carboxy-terminal end. The data indicate that syntaxin and VAMP bind primarily in a parallel arrangement and suggest a coiled-coil structure that is bent rather than fully extended. We propose a model in which binding of SNAP receptor (SNARE) protein coiled-coil domains helps drive vesicle fusion.
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Cites
Predicting coiled coils from protein sequences.
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Fluorescence Energy Transfer as a Spectroscopic Ruler
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Core Structure of gp41 from the HIV Envelope Glycoprotein
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Atomic structure of the ectodomain from HIV-1 gp41
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Resonance Energy Transfer: Methods and Applications
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A spring-loaded mechanism for the conformational change of influenza hemagglutinin
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Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.
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Specificity and regulation of a synaptic vesicle docking complex
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Self-citationSec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles
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Cited by
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Self-citationMembrane Fusion and Exocytosis
Jahn, R., & Südhof, T. C. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,259
Cai, H., Reinisch, K., & Ferro-Novick, S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.005 · Cited by 685
Snares and Munc18 in synaptic vesicle fusion
Rizo, J., & Südhof, T. C. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn898 · Cited by 539
Mechanisms of Synaptic Vesicle Exocytosis
Lin, R. C., & Scheller, R. H. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.19 · Cited by 512
Self-citation
Metadata
- Authors
- Lin, R. C., & Scheller, R. H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 19
- Issue
- 5
- Pages
- 1087-1094
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2120405274
- Cited by
- 344
- References
- 22
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
