The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands
Open accessAbstract
Localizing cell surface receptors to specific subcellular positions can be critical for their proper functioning, as most notably demonstrated at neuronal synapses. PDZ proteins apparently play critical roles in such protein localizations. Receptor tyrosine kinases have not been previously shown to interact with PDZ proteins in vertebrates. We report that Eph receptors and their membrane-linked ligands all contain PDZ recognition motifs and can bind and be clustered by PDZ proteins. In addition, we find that Eph receptors and ligands colocalize with PDZ proteins at synapses. Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse.
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Cites
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AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Self-citationStargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
Self-citationPDZ Domains: Structural Modules for Protein Complex Assembly
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Metadata
- Authors
- Torres, R., Firestein, B. L., Dong, H., Staudinger, J., Olson, E. N., Huganir, R. L., Bredt, D. S., Gale, N. W., & Yancopoulos, G. D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 21
- Issue
- 6
- Pages
- 1453-1463
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1995691453
- Cited by
- 451
- References
- 53
- FWCI
- 15.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands. https://app.cochat.ai/papers/10.1016/s0896-6273(00)80663-7
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- Torres, R., Firestein, B. L., Dong, H., Staudinger, J., Olson, E. N., Huganir, R. L., Bredt, D. S., Gale, N. W., & Yancopoulos, G. D. (1998). PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands. Neuron. https://doi.org/10.1016/s0896-6273(00)80663-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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