Cited by 295Neuroscience and Neuropharmacology ResearchCellular transport and secretionGenetics and Neurodevelopmental Disorders

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Piccolo, a Presynaptic Zinc Finger Protein Structurally Related to Bassoon

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Fenster, Steven D, Chung, Wook Joon, Zhai, Rong, Cases-Langhoff, Claudia, Voss, Britta, Garner, Abigail M, Kaempf, Udo, Kindler, Stefan, Gundelfinger, Eckart D, Garner, Craig C·2000·Neuron

DOI 10.1016/s0896-6273(00)80883-1

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Abstract

Piccolo is a novel component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release. Analysis of its primary structure reveals that Piccolo is a multidomain zinc finger protein structurally related to Bassoon, another PCM protein. Both proteins were found to be shared components of glutamatergic and GABAergic CNS synapses but not of the cholinergic neuromuscular junction. The Piccolo zinc fingers were found to interact with the dual prenylated rab3A and VAMP2/Synaptobrevin II receptor PRA1. We show that PRA1 is a synaptic vesicle-associated protein that is colocalized with Piccolo in nerve terminals of hippocampal primary neurons. These data suggest that Piccolo plays a role in the trafficking of synaptic vesicles (SVs) at the active zone.

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Authors: Fenster, S. D., Chung, W. J., Zhai, R., Cases-Langhoff, C., Voss, B., Garner, A. M., Kaempf, U., Kindler, S., Gundelfinger, E. D., & Garner, C. C.
Affiliations: University of Alabama at Birmingham (US)
Universität Hamburg (DE)
Leibniz Institute for Neurobiology (DE)
Corresponding author: Garner, Craig C
ORCID: Fenster, Steven D
Zhai, Rong
Kindler, Stefan
Gundelfinger, Eckart D
Garner, Craig C
Venue: Neuron
Publisher: Elsevier BV
Published: 2000-01
Volume: 25
Issue: 1
Pages: 203-214
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80883-1
OpenAlex: W1970539905
Cited by: 295
References: 49
Citations by year: 2026: 5 · 2025: 2 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 14 · 2016: 13 · 2015: 16 · 2014: 11 · 2013: 11 · 2012: 14
FWCI: 7.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4946 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ag006569-13, 5p50hd032901-05, 5r01ag012978-04)
National Institute on Aging (AG 06569-09, AG12978-02)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50 HD32901)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: piccolo, bassoon, active zone, zinc finger proteins, synaptic vesicle trafficking, Rab3A, PRA1, glutamatergic synapses, GABAergic synapses, hippocampal neurons, neurotransmitter release
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Cells, Cultured, Cytoskeletal Proteins, Exons, Fungal Proteins, gamma-Aminobutyric Acid, Hippocampus, Humans, Introns, Membrane Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Neuropeptides, Rabbits, Receptors, Cell Surface, Zinc Fingers, Presynaptic Terminals, Glutamic Acid, GTP-Binding Proteins, rab3A GTP-Binding Protein, Vesicular Transport Proteins, R-SNARE Proteins, Mice, Rats

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Piccolo, a Presynaptic Zinc Finger Protein Structurally Related to Bassoon

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