The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inactivation of Presynaptic Calcium Current Contributes to Synaptic Depression at a Fast Central Synapse
Open accessAbstract
Voltage-gated calcium channels are well characterized at neuronal somata but less thoroughly understood at the presynaptic terminal where they trigger transmitter release. In order to elucidate how the intrinsic properties of presynaptic calcium channels influence synaptic function, we have made direct recordings of the presynaptic calcium current (I(pCa)) in a brainstem giant synapse called the calyx of Held. The current was pharmacologically classified as P-type and exhibited marked inactivation. The inactivation was largely dependent upon the inward calcium current magnitude rather than the membrane potential, displayed little selectivity between divalent charge carriers (Ca2+, Ba2+ and Sr+), and exhibited slow recovery. Simultaneous pre- and postsynaptic whole-cell recording revealed that I(pCa) inactivation predominantly contributes to posttetanic depression of EPSCs. Thus, because of its slow recovery, I(pCa) inactivation underlies this short-term synaptic plasticity.
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Citations
Cites
Presynaptic Calcium Current Modulation by a Metabotropic Glutamate Receptor
Takahashi, T., Forsythe, I. D., Tsujimoto, T., Barnes-Davies, M., & Onodera, K. (1996) · Science · doi:10.1126/science.274.5287.594 · Cited by 392
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Cited by
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Voltage-Gated Calcium Channels
Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628
Calcium Channel Regulation and Presynaptic Plasticity
Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
Calcium- and activity-dependent synaptic plasticity
Zucker, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80045-2 · Cited by 616
Short-Term Presynaptic Plasticity
Regehr, W. G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005702 · Cited by 482
Metadata
- Authors
- Forsythe, I. D., Tsujimoto, T., Barnes-Davies, M., Cuttle, M. F., & Takahashi, T.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 20
- Issue
- 4
- Pages
- 797-807
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2025853041
- Cited by
- 356
- References
- 1
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Forsythe, I. D., Tsujimoto, T., Barnes-Davies, M., Cuttle, M. F., & Takahashi, T. (1998). Inactivation of Presynaptic Calcium Current Contributes to Synaptic Depression at a Fast Central Synapse. Neuron. https://doi.org/10.1016/s0896-6273(00)81017-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
