The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Orexin Synthesis and Response in the Gut
Open accessAbstract
Orexin (hypocretin) appears to play a role in the regulation of energy balances. Previous reports have indicated that orexin-containing neurons are found only in the lateral hypothalamic (LH) area. We show that a subset of neurons in the gut which also express leptin receptors display orexin-like immunoreactivity and express functional orexin receptors. Orexin excites secretomotor neurons in the guinea pig submucosal plexus and increases motility. Moreover, fasting upregulates the phosphorylated form of cAMP response element-binding protein (pCREB) in orexin-immunoreactive neurons, indicating a functional response to food status in these cells. Together, these data suggest that orexin in the gut may play an even more intimate role in regulating energy homeostasis than it does in the CNS.
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Physiology of the Gastrointestinal Tract
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
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Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Identification of targets of leptin action in rat hypothalamus.
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The Enteric Nervous System: 30 Years Later
(2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-27592-5 · Cited by 1,091
Physiology of the Gastrointestinal Tract
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Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
Elias, C. F., Saper, C. B., Maratos-Flier, E., Tritos, N. A., Lee, C., Kelly, J., Tatro, J. B., Hoffman, G. E., Ollmann, M. M., Barsh, G. S., et al. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981228)402:4<442::aid-cne2>3.0.co;2-r · Cited by 852
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
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Cited by
The hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X. J., Harrold, J. A., King, P. J., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 578
Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
Inui, A., Asakawa, A., Y. Bowers, C., Mantovani, G., Laylano, A., M. Meguid, M., & Fujimiya, M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0641rev · Cited by 431
The hypocretins: Setting the arousal threshold
Sutcliffe, J. G., & de Lecea, L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn808 · Cited by 422
Hormonal regulation of food intake
Stanley, S., Wynne, K., McGowan, B., & Bloom, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00015.2004 · Cited by 372
Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y., Williams, S. C., Sakurai, T., & Yanagisawa, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.010 · Cited by 262
Metadata
- Authors
- Kirchgessner, A. L., & Liu, M.-T.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 24
- Issue
- 4
- Pages
- 941-951
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2107370312
- Cited by
- 324
- References
- 46
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
