β-Synuclein Inhibits α-Synuclein Aggregation

α-Synuclein in Lewy bodies

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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

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A Drosophila model of Parkinson's disease

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High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

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Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

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Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

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NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

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Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

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Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

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α-Synuclein Stimulates Differentiation of Osteosarcoma Cells

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Disease modifying effect of adiponectin in model of α ‐synucleinopathies

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Synphilin in normal human brains and in synucleinopathies: studies with new antibodies

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Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity

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Quantifying Interactions of β-Synuclein and γ-Synuclein with Model Membranes

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β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer’s disease

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Molecular Ageing of Alpha- and Beta-Synucleins: Protein Damage and Repair Mechanisms

Vigneswara, V., Cass, S., Wayne, D., Bolt, E. L., Ray, D. E., & Carter, W. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061442 · Cited by 33

Development of New Treatments for Parkinson’s Disease in Transgenic Animal Models: A Role for β-Synuclein

Masliah, E., & Hashimoto, M. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00029-3 · Cited by 33

Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene

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Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein

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The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons

Anderson, E. N., Hirpa, D., Zheng, K. H., Banerjee, R., & Gunawardena, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00540 · Cited by 32

Alpha- and beta-synuclein expression in Parkinson disease with and without dementia

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Proteomic modification in gills and brains of medaka fish (Oryzias melastigma) after exposure to a sodium channel activator neurotoxin, brevetoxin-1

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β‐Synuclein exhibits chaperone activity more efficiently than α‐synuclein

Lee, D., Paik, S. R., & Choi, K. Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.075 · Cited by 32

Effect of metals on herbicides–α‐synuclein association: A possible factor in neurodegenerative disease studied by capillary electrophoresis

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Genetics of synucleins in neurodegenerative diseases

Brás, J., Gibbons, E., & Guerreiro, R. J. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02202-1 · Cited by 30

α-Synuclein Aggregation and Modulating Factors

Paleologou, K. E., & El‐Agnaf, O. M. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_6 · Cited by 33

Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies

Sekiya, H., Matsubara, T., Deture, M. A., & Dickson, D. W. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00900-6 · Cited by 35

Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?

Buchman, V. L., & Ninkina, N. N. (2008) · Neurotoxicity Research · doi:10.1007/bf03033857 · Cited by 29

Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder

Sriwimol, W., & Limprasert, P. (2018) · BioMed Research International · doi:10.1155/2018/4503871 · Cited by 34

Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein

Williams, J. K., Yang, X., Atieh, T. B., Olson, M. P., Khare, S. D., & Baum, J. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.024 · Cited by 27

Pick's disease: α- and β-synuclein-immunoreactive Pick bodies in the dentate gyrus

Mori, F., Hayashi, S., Yamagishi, S., Yoshimoto, M., Yagihashi, S., Takahashi, H., & Wakabayashi, K. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0578-9 · Cited by 27

Validity of the MPTP-Treated Mouse as a Model for Parkinson’s Disease

Klemann, C. J. H. M., Martens, G. J. M., Poelmans, G., & Visser, J. E. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9103-8 · Cited by 29

Interactions between the Intrinsically Disordered Proteins β‐Synuclein and α‐Synuclein

Williams, J. K., Yang, X., & Baum, J. (2018) · PROTEOMICS · doi:10.1002/pmic.201800109 · Cited by 26

Evolutionary aspects of the synuclein super-family and sub-families based on large-scale phylogenetic and group-discrimination analysis

Yuan, J., & Zhao, Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.09.132 · Cited by 26

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein

Leitao, A. D. G., Bhumkar, A., Hunter, D. J. B., Gambin, Y., & Sierecki, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020334 · Cited by 26

Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases

Huynh, N. V., Wang, S., Ouyang, X., Wani, W. Y., Johnson, M. S., Chacko, B. K., Jegga, A. G., Qian, W., Chatham, J. C., Darley-Usmar, V. M., et al. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.757801 · Cited by 24

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins

Ninkina, N. N., Millership, S. J., Peters, O. M., Connor‐Robson, N., Chaprov, K., Kopylov, A. T., Montoya, A., Kramer, H., Withers, D. J., & Buchman, V. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101375 · Cited by 25

Synuclein Proteins of the Pufferfish Fugu rubripes: Sequences and Functional Characterization

Yoshida, H., Craxton, M., Jakes, R., Zibaee, S., Tavaré, R., Fraser, G. M., Serpell, L. C., Davletov, B. A., Crowther, R. A., & Goedert, M. (2006) · Biochemistry · doi:10.1021/bi051993m · Cited by 25

Evolvability of Amyloidogenic Proteins in Human Brain

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Proteomic Analysis of the Genotoxicant Methylazoxymethanol (MAM)-Induced Changes in the Developing Cerebellum

Kisby, G., Standley, M. S., Park, T., Olivas, A., Fei, S. S., Jacob, T., Reddy, A. P., Lu, X., Pattee, P., & Nagalla, S. R. (2006) · Journal of Proteome Research · doi:10.1021/pr060126g · Cited by 24

Toxic effects of human and rodent variants of alpha‐synuclein in vivo

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Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity

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LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson’s Disease

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Reciprocal accumulation of β-synuclein in α-synuclein lesions in multiple system atrophy

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Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level

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New brain-specific beta-synuclein isoforms show expression ratio changes in Lewy body diseases

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Calibrated Langevin-dynamics simulations of intrinsically disordered proteins

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Beta-synuclein gene variants and Parkinson's disease: A preliminary case-control study

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The role of gamma‐synuclein in cocaine‐induced behaviour in rats

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Dementia with Lewy bodies

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Lewy Body Disorders

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Parkinson’s Genetics: Molecular Insights for the New Millennium

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Dimerization propensities of Synucleins are not predictive for Synuclein aggregation

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Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro

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Effects of Environmental Tobacco Smoke on Adult Rat Brain Biochemistry

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Dementia with Lewy bodies—associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions

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The role of α-synuclein in neurodegeneration — An update

Jellinger, K. A. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0013-1 · Cited by 19

Intrinsic Disorder in Proteins Associated with Neurodegenerative Diseases

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Transcriptional Regulation of the Beta-Synuclein 5′-Promoter Metal Response Element by Metal Transcription Factor-1

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Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

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Literature-Related Discovery (LRD)

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Peripheral Sensory Neurons Survive in the Absence of α- and γ-Synucleins

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Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

Lothian, A., Lago, L., Mukherjee, S., Connor, A. R., Fowler, C. J., McLean, C., Horne, M. K., Masters, C. L., Cappai, R., & Roberts, B. R. (2018) · Metallomics · doi:10.1039/c8mt00223a · Cited by 18

Solution NMR insights into dynamic supramolecular assemblies of disordered amyloidogenic proteins

Munari, F., D’Onofrio, M., & Assfalg, M. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108304 · Cited by 18

Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H β-synuclein

Sekiyama, K., Fujita, M., Sekigawa, A., Takamatsu, Y., Waragai, M., Takenouchi, T., Sugama, S., & Hashimoto, M. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.037 · Cited by 18

Characterization of three synuclein genes in Xenopus laevis

Wang, C., Liu, Y. Z., Chan, W. Y., Chan, S. O., Grunz, H., & Zhao, H. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22693 · Cited by 18

β-Synuclein-Derived Peptides With Neuroprotective Activity: An Alternative Treatment of Neurodegenerative Disorders?

Windisch, M., Hutter‐Paier, B., Schreiner, E., & Wronski, R. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:1:155 · Cited by 18

Protection against neurodegenerative disease on Earth and in space

Takamatsu, Y., Koike, W., Takenouchi, T., Sugama, S., Wei, J., Waragai, M., Sekiyama, K., & Hashimoto, M. (2016) · npj Microgravity · doi:10.1038/npjmgrav.2016.13 · Cited by 16

Recent advances in our understanding of Parkinson's disease

Kim, S. W., Ko, H. S., Dawson, V. L., & Dawson, T. M. (2005) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2005.11.015 · Cited by 17

The loss of inhibitory C‐terminal conformations in disease associated P123H β‐synuclein

Janowska, M. K., & Baum, J. (2015) · Protein Science · doi:10.1002/pro.2798 · Cited by 16

Recent advances in the genetics of dementia with Lewy bodies

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Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1

Shimshek, D. R., Schweizer, T., Schmid, P., & van der Putten, P. H. (2012) · Scientific Reports · doi:10.1038/srep00262 · Cited by 16

Applications of microarray and bioinformatics tools to dissect molecular responses of the central nervous system to antioxidant micronutrients

Gohil, K., & Chakraborty, A. A. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.009 · Cited by 16

Chaperone and anti‐chaperone: Two‐faced synuclein as stimulator of synaptic evolution

Fujita, M., Wei, J., Nakai, M., Masliah, E., & Hashimoto, M. (2006) · Neuropathology · doi:10.1111/j.1440-1789.2006.00732.x · Cited by 16

Mechanisms and models of α-synuclein-related neurodegeneration

Springer, W., & Kahle, P. J. (2006) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-996-0025-8 · Cited by 16

Exploring the Impact of Physiological C-Terminal Truncation on α-Synuclein Conformations to Unveil Mechanisms Regulating Pathological Aggregation

Huang, F., Yan, J., Xu, H., Wang, Y., Zhang, X., Zou, Y. F., Lian, J., Ding, F., & Sun, Y. (2024) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.4c01839 · Cited by 15

Motor and Nonmotor Symptoms of Parkinson’s Disease: Antagonistic Pleiotropy Phenomena Derived fromα-Synuclein Evolvability?

Takamatsu, Y., Fujita, M., Ho, G. J., Wada, R., Sugama, S., Takenouchi, T., Waragai, M., Masliah, E., & Hashimoto, M. (2018) · Parkinson s Disease · doi:10.1155/2018/5789424 · Cited by 15

Alpha- and Beta-Synucleins mRNA Expression in Lymphocytes of Schizophrenia Patients

Noori–Daloii, M. R., Kheirollahi, M., Mahbod, P., Mohammadi, F., Astaneh, A. N., Zarindast, M. R., Azimi, C., & Mohammadi, M. R. (2010) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2010.0050 · Cited by 15

Investigation of Intramolecular Dynamics and Conformations of α-, β- and γ-Synuclein

Ducas, V. C., & Rhoades, E. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086983 · Cited by 15

Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation

Sharma, K., Mehra, S., Sawner, A. S., Markam, P. S., Panigrahi, R., Navalkar, A., Chatterjee, D., Kumar, R., Kadu, P., Patel, K., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00405 · Cited by 15

Emerging perspectives of copper-mediated transcriptional regulation in mammalian cell development

Fitisemanu, F. M., & Padilla‐Benavides, T. (2024) · Metallomics · doi:10.1093/mtomcs/mfae046 · Cited by 14

Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies

Sekigawa, A., Takamatsu, Y., Sekiyama, K., & Hashimoto, M. (2015) · Biomolecules · doi:10.3390/biom5021000 · Cited by 14

Bioinorganic Chemistry of Parkinson’s Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein

Miotto, M., Pavese, M. D., Quintanar, L., Zweckstetter, M., Griesinger, C., & Fernández, C. O. (2017) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.7b01292 · Cited by 14

Synuclein-γ promotes migration of MCF7 breast cancer cells by activating extracellular-signal regulated kinase pathway and breaking cell-cell junctions

Zhuang, Q., Liu, C., Qu, L., & Shou, C. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3799 · Cited by 14

Identification of potential drugs for Parkinson's disease based on a sub-pathway method

Sun, A.-G., Lin, A.-Q., Huang, S., Huo, D., & Cong, C. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.986673 · Cited by 14

Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease

Gruschus, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133863 · Cited by 13

Potential of mean force and molecular dynamics study on the transient interactions between α and β synuclein that drive inhibition of α-synuclein aggregation

Sanjeev, A., Sahu, R. K., & Mattaparthi, V. S. K. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1254119 · Cited by 13

Sumoylation Protects Against β-Synuclein Toxicity in Yeast

Popova, B., Kleinknecht, A., Arendarski, P., Mischke, J., Wang, D., & Braus, G. H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00094 · Cited by 13

Alpha-synuclein transgenic mice: Relevance to multiple system atrophy

Fillon, G., & Kahle, P. J. (2005) · Movement Disorders · doi:10.1002/mds.20542 · Cited by 13

Functional genomics identifies novel and diverse molecular targets of nutrients in vivo

Gohil, K. (2004) · Biological Chemistry · doi:10.1515/bc.2004.085 · Cited by 13

The Synucleins and the Astrocyte

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Hydrogen Sulfide and β-Synuclein Are Involved and Interlinked in the Aging Glaucomatous Retina

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