unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion
Open accessAbstract
Mechanically gated ion channels are important modulators of coordinated movement, yet little is known of their molecular properties. We report that C. elegans unc-8, originally identified by gain-of-function mutations that induce neuronal swelling and severe uncoordination, encodes a DEG/ENaC family member homologous to subunits of a candidate mechanically gated ion channel. unc-8 is expressed in several sensory neurons, interneurons, and motor neurons. unc-8 null mutants exhibit previously unrecognized but striking defects in the amplitude and wavelength of sinusoidal tracks inscribed as they move through an E. coli lawn. We hypothesize that UNC-8 channels could modulate coordinated movement in response to body stretch. del-1, a second DEG/ENaC family member coexpressed with unc-8 in a subset of motor neurons, might also participate in a channel that contributes to nematode proprioception.
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Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288 · see citing works
The structure of the nervous system of the nematode <i>Caenorhabditis elegans</i>
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“This staining is likely to occurproposed to be stretch sensitive [White et al., 1986]). in the embryonically derived DA, DB, and/or DD motorInterestingly, we find that tracks inscribed in an E. coli neurons. b-galactosidase activity is observed in addi-lawn by unc-8 null mutants are significantly…”
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“Indeed, the stretch receptor hypothesis is widely recognized as an attractive and plausible conjecture (Riddle et al., 1997; Tavernarakis et al., 1997; Bryden and Cohen, 2004, 2008; O’Hagan and Chalfie, 2005; Karbowski et al., 2008) and forms the basis of our model.”
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- Authors
- Tavernarakis, N., Shreffler, W., Wang, S., & Driscoll, M.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- NYU Langone Health (US)
- Corresponding author
- Driscoll, Monica
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 18
- Issue
- 1
- Pages
- 107-119
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1982816670
- Cited by
- 196
- References
- 2
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 10
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (T32GM007308)
- National Institute of Neurological Disorders and Stroke (R01NS034435, NS34435)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- unc-8, mechanosensitive ion channels, Caenorhabditis elegans locomotion, Del-1, proprioception, motor neurons, sensory neurons, interneurons, neuronal swelling
- MeSH terms
- Amino Acid Sequence, Animals, Ion Channels, Molecular Sequence Data, Motor Activity, Recombinant Proteins, Ion Channel Gating, Helminth Proteins, Polymerase Chain Reaction, Mutagenesis, Caenorhabditis elegans, Genes, Helminth, Sequence Homology, Amino Acid, DNA Primers, Caenorhabditis elegans Proteins
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